CAR-T Cell Therapy in Ovarian Cancer: Where Are We Now?

• Published in: Diagnostics (Basel) Vol. 14; no. 8; p. 819
• Main Authors: Cutri-French, Clare, Nasioudis, Dimitrios, George, Erin, Tanyi, Janos L.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Antigens; B cells; Cancer therapies; CAR-T therapy; Care and treatment; Cell adhesion & migration; Cell division; Clinical trials; Cytokines; Dendritic cells; Design; Development and progression; Endometrium; Epidermal growth factor; Folic acid; Glycoproteins; Health aspects; Immunotherapy; Kidneys; Kinases; Lungs; Lymphocytes; mesothelin; Mesothelioma; Metastasis; Ovarian cancer; Pancreas; Proteins; Stem cells; T cells; target antigens; Tumors; Uterus; Vitamin B; ovarian cancer; target antigens; CAR-T therapy; mesothelin

The success of chimeric antigen receptor T-cell (CAR-T) therapies in the treatment of hematologic malignancies has led to the investigation of their potential in the treatment of solid tumors, including ovarian cancer. While the immunosuppressive microenvironment of ovarian cancer has been a barrier...