The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 41; no. 13; pp. 3080 - 3091
• Main Authors: Oh, Hyunjung, Lewis, David A, Sibille, Etienne
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.12.2016
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Aging; Animals; Atrophy; Brain research; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; Female; gamma-Aminobutyric Acid - metabolism; Gene Expression Profiling; Gene Expression Regulation - genetics; Humans; Kinases; Male; Medical research; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mental depression; Mental disorders; Mental health; Mice; Mice, Transgenic; Middle Aged; Neuronal Plasticity - genetics; Oligonucleotide Array Sequence Analysis; Original; Prefrontal Cortex - physiology; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; Receptor, trkB; RNA, Messenger - metabolism; Signal Transduction - physiology; Synapses - genetics; Young Adult; Toronto Ontario Canada; Canada

Reduced brain-derived neurotrophic factor (BDNF) may underlie age-related synaptic loss, in turn contributing to cerebral atrophy, cognitive decline, and increased risk for psychiatric disorders. However, the specific contribution of BDNF to the age-related expression changes in synaptic markers and...