Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease

• Published in: Scientific reports Vol. 9; no. 1; p. 7029
• Main Authors: Freire, Rachel, Ingano, Laura, Serena, Gloria, Cetinbas, Murat, Anselmo, Anthony, Sapone, Anna, Sadreyev, Ruslan I., Fasano, Alessio, Senger, Stefania
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.05.2019; Nature Publishing Group
• Subjects: 13/1; 13/100; 13/106; 13/2; 13/21; 13/31; 13/51; 14/19; 38/22; 38/39; 38/91; 631/532/2437; 692/4020/1503/1702/1357; Adaptive immunity; Adult; Aged; Autoimmune diseases; Celiac disease; Celiac Disease - genetics; Celiac Disease - microbiology; Celiac Disease - pathology; Cell Proliferation; Cytokines; Cytokines - metabolism; Digestive system; Duodenum - cytology; Duodenum - pathology; Dysbiosis - metabolism; Epithelium; Gastrointestinal Microbiome - genetics; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Gene Expression; Gliadin; Gliadin - metabolism; Gliadin - pharmacology; Gluten; Glutens - metabolism; Glutens - pharmacology; Humanities and Social Sciences; Humans; Immune response; Immunological tolerance; Inflammation; Innate immunity; Intestinal Mucosa - cytology; Intestinal Mucosa - drug effects; Intestinal Mucosa - pathology; Intestine; Lactic acid; Microbiota; Middle Aged; multidisciplinary; Organoids; Pathogenesis; Permeability; Polysaccharides; Reproducibility of Results; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Stem cells; Stem Cells - pathology

Celiac disease (CD) is an immune-mediated disorder triggered by gluten exposure. The contribution of the adaptive immune response to CD pathogenesis has been extensively studied, but the absence of valid experimental models has hampered our understanding of the early steps leading to loss of gluten...