Whole genome sequencing reveals extended natural transformation in Campylobacter impacting diagnostics and the pathogens adaptive potential

• Published in: Scientific reports Vol. 10; no. 1; p. 3686
• Main Authors: Golz, Julia C., Epping, Lennard, Knüver, Marie-Theres, Borowiak, Maria, Hartkopf, Felix, Deneke, Carlus, Malorny, Burkhard, Semmler, Torsten, Stingl, Kerstin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.02.2020; Nature Publishing Group
• Subjects: 45; 45/43; 631/326/171/1495; 631/326/41/2530; 631/326/421; Animals; Biosynthesis; Campylobacter; Campylobacter coli - genetics; Campylobacter coli - pathogenicity; Campylobacter Infections - diagnosis; Campylobacter Infections - genetics; Campylobacter Infections - microbiology; Campylobacter jejuni - growth & development; Campylobacter jejuni - pathogenicity; Cell walls; Chemotaxis; Eggs; Gastroenteritis; Gastroenteritis - diagnosis; Gastroenteritis - genetics; Gastroenteritis - microbiology; Gene transfer; Genetic transformation; Genetic Variation; Genome, Bacterial; Genomes; Harsh environments; Horizontal transfer; Humanities and Social Sciences; Humans; multidisciplinary; Phylogeny; Public health; Recombination; Recombination, Genetic; Science; Science (multidisciplinary); Species; Strains (organisms); Typing; Whole Genome Sequencing

Campylobacter is the major bacterial agent of human gastroenteritis worldwide and represents a crucial global public health burden. Species differentiation of C. jejuni and C. coli and phylogenetic analysis is challenged by inter-species horizontal gene transfer. Routine real-time PCR on more than 4...