Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development

While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro models are needed. Our work strives to mimic the melanoma microenvironment in vitro as an alternative to animal testing. We used the self-asse...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 8; no. 1; pp. 13191 - 13
Main Authors Bourland, Jennifer, Fradette, Julie, Auger, François A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 04.09.2018
Nature Publishing Group
Subjects
13/106
13/107
14/1
14/19
14/34
631/67
631/80
82
Antineoplastic Agents - pharmacology
Apoptosis
Biomaterials
Blood
Capillaries
Cell culture
Cell Line
Cell Line, Tumor
Cell Proliferation - drug effects
Drug development
Drug Development - methods
Drug Screening Assays, Antitumor - methods
Epidermis
Extracellular matrix
Filaggrin
Filaggrin Proteins
Humanities and Social Sciences
Humans
Laminin
Lymphatic Vessels - drug effects
Lymphatic Vessels - pathology
Melanoma
Melanoma - blood supply
Melanoma - drug therapy
Melanoma - pathology
multidisciplinary
Science
Science (multidisciplinary)
Self-assembly
Skin cancer
Skin Neoplasms - blood supply
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Tissue engineering
Tissue Engineering - methods
Tumor Microenvironment - drug effects
Vemurafenib - pharmacology
Online AccessGet full text

Cover

Abstract While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro models are needed. Our work strives to mimic the melanoma microenvironment in vitro as an alternative to animal testing. We used the self-assembly method to produce a 3D human melanoma model exempt of exogenous biomaterial. This model is based on primary human skin cells and melanoma cell lines while including a key feature for tumor progression: blood and lymphatic capillaries. Major components of the tumor microenvironment such as capillaries, human extracellular matrix, a stratified epidermis (involucrin, filaggrin) and basement membrane (laminin 332) are recapitulated in vitro . We demonstrate the persistence of CD31 + blood and podoplanin + /LYVE-1 + lymphatic capillaries in the engineered tissue. Chronic treatment with vemurafenib was applied to the model and elicited a dose-dependent response on proliferation and apoptosis, making it a promising tool to test new compounds in a human-like environment.
AbstractList While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro models are needed. Our work strives to mimic the melanoma microenvironment in vitro as an alternative to animal testing. We used the self-assembly method to produce a 3D human melanoma model exempt of exogenous biomaterial. This model is based on primary human skin cells and melanoma cell lines while including a key feature for tumor progression: blood and lymphatic capillaries. Major components of the tumor microenvironment such as capillaries, human extracellular matrix, a stratified epidermis (involucrin, filaggrin) and basement membrane (laminin 332) are recapitulated in vitro. We demonstrate the persistence of CD31 blood and podoplanin /LYVE-1 lymphatic capillaries in the engineered tissue. Chronic treatment with vemurafenib was applied to the model and elicited a dose-dependent response on proliferation and apoptosis, making it a promising tool to test new compounds in a human-like environment.
While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro models are needed. Our work strives to mimic the melanoma microenvironment in vitro as an alternative to animal testing. We used the self-assembly method to produce a 3D human melanoma model exempt of exogenous biomaterial. This model is based on primary human skin cells and melanoma cell lines while including a key feature for tumor progression: blood and lymphatic capillaries. Major components of the tumor microenvironment such as capillaries, human extracellular matrix, a stratified epidermis (involucrin, filaggrin) and basement membrane (laminin 332) are recapitulated in vitro . We demonstrate the persistence of CD31 + blood and podoplanin + /LYVE-1 + lymphatic capillaries in the engineered tissue. Chronic treatment with vemurafenib was applied to the model and elicited a dose-dependent response on proliferation and apoptosis, making it a promising tool to test new compounds in a human-like environment.
Abstract While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro models are needed. Our work strives to mimic the melanoma microenvironment in vitro as an alternative to animal testing. We used the self-assembly method to produce a 3D human melanoma model exempt of exogenous biomaterial. This model is based on primary human skin cells and melanoma cell lines while including a key feature for tumor progression: blood and lymphatic capillaries. Major components of the tumor microenvironment such as capillaries, human extracellular matrix, a stratified epidermis (involucrin, filaggrin) and basement membrane (laminin 332) are recapitulated in vitro . We demonstrate the persistence of CD31 + blood and podoplanin + /LYVE-1 + lymphatic capillaries in the engineered tissue. Chronic treatment with vemurafenib was applied to the model and elicited a dose-dependent response on proliferation and apoptosis, making it a promising tool to test new compounds in a human-like environment.
While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro models are needed. Our work strives to mimic the melanoma microenvironment in vitro as an alternative to animal testing. We used the self-assembly method to produce a 3D human melanoma model exempt of exogenous biomaterial. This model is based on primary human skin cells and melanoma cell lines while including a key feature for tumor progression: blood and lymphatic capillaries. Major components of the tumor microenvironment such as capillaries, human extracellular matrix, a stratified epidermis (involucrin, filaggrin) and basement membrane (laminin 332) are recapitulated in vitro. We demonstrate the persistence of CD31+ blood and podoplanin+/LYVE-1+ lymphatic capillaries in the engineered tissue. Chronic treatment with vemurafenib was applied to the model and elicited a dose-dependent response on proliferation and apoptosis, making it a promising tool to test new compounds in a human-like environment.
ArticleNumber 13191
Author Auger, François A.
Fradette, Julie
Bourland, Jennifer
Author_xml – sequence: 1
  givenname: Jennifer
  surname: Bourland
  fullname: Bourland, Jennifer
  organization: Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Division of Regenerative Medicine, CHU de Québec–Université Laval Research Center, Department of Surgery, Faculty of Medicine, Université Laval
– sequence: 2
  givenname: Julie
  surname: Fradette
  fullname: Fradette, Julie
  organization: Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Division of Regenerative Medicine, CHU de Québec–Université Laval Research Center, Department of Surgery, Faculty of Medicine, Université Laval
– sequence: 3
  givenname: François A.
  orcidid: 0000-0003-4031-6133
  surname: Auger
  fullname: Auger, François A.
  email: francois.auger@fmed.ulaval.ca
  organization: Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX, Division of Regenerative Medicine, CHU de Québec–Université Laval Research Center, Department of Surgery, Faculty of Medicine, Université Laval
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30181613$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1vFiEUhYlpY2vtH3BhSNy4GeVjoLAxMfUzadJNXRrCwJ33pWFghJk2_fdi37ZWF2UDyX3uufdwXqC9lBMg9IqSd5Rw9b72VGjVEao6TgVhnXyGDhnpRcc4Y3uP3gfouNZL0o5guqf6OTrgrY1Kyg_Rz4tQ6wodpE1IAAU85p_wBNGmPFk8ZQ8RX4dli4eYs8c2eRxvpnlrl-Cws3OI0ZYAFY-5YF_WDfZwBTHPE6TlJdofbaxwfHcfoR9fPl-cfuvOzr9-P_141jlB6dKdjANRJ0w43duRS9nTngtvOQxgwQ2DYJIB670HrrQcpNCMKM4JCHBOUcWP0Ied7rwOE3jXRhcbzVzCZMuNyTaYfyspbM0mXxlJGe-JaAJv7wRK_rVCXcwUqoPmLUFeq2FEa6WF0qShb_5DL_NaUrN3S_Xtb6VuFNtRruRaC4wPy1Bi_gRodgGaloS5DdDI1vT6sY2Hlvu4GsB3QG2ltIHyd_YTsr8BPmCoyA
CitedBy_id crossref_primary_10_1002_advs_202202093
crossref_primary_10_3390_cancers14143535
crossref_primary_10_1007_s12195_023_00780_0
crossref_primary_10_1088_1758_5090_abfca8
crossref_primary_10_3390_cancers15245779
crossref_primary_10_3390_bioengineering8070099
crossref_primary_10_1016_j_prp_2024_155231
crossref_primary_10_1039_D3LC00486D
crossref_primary_10_3390_pharmaceutics14020319
crossref_primary_10_1016_j_actbio_2024_02_023
crossref_primary_10_1016_j_biomaterials_2021_120943
crossref_primary_10_1016_j_atherosclerosis_2024_118529
crossref_primary_10_3390_cancers13122970
crossref_primary_10_1039_D2BM02060B
crossref_primary_10_1152_ajpcell_00380_2020
crossref_primary_10_1155_2020_6051210
crossref_primary_10_1186_s12967_024_05113_x
crossref_primary_10_3390_cancers15102849
crossref_primary_10_1016_j_bbagen_2022_130183
crossref_primary_10_1111_exd_14675
crossref_primary_10_1111_jcmm_16578
crossref_primary_10_3390_bioengineering7030115
crossref_primary_10_1016_j_addr_2020_08_001
crossref_primary_10_18632_oncotarget_27570
crossref_primary_10_1186_s13148_022_01364_x
crossref_primary_10_1126_sciadv_ade2514
crossref_primary_10_1002_biot_202000250
crossref_primary_10_3390_jcm10132790
crossref_primary_10_1016_j_jcyt_2020_10_001
crossref_primary_10_3390_cancers13225788
crossref_primary_10_1007_s00105_019_04537_7
crossref_primary_10_1007_s00262_020_02626_4
crossref_primary_10_3390_bioengineering9010028
crossref_primary_10_3390_biom11020131
crossref_primary_10_1101_cshperspect_a041169
crossref_primary_10_1161_STROKEAHA_120_032691
crossref_primary_10_1002_art_42097
crossref_primary_10_1016_j_atherosclerosis_2024_117458
crossref_primary_10_1089_ten_tea_2023_0204
crossref_primary_10_1111_pcmr_13092
crossref_primary_10_1111_micc_12793
crossref_primary_10_1038_s41598_022_19307_0
crossref_primary_10_3389_fcell_2020_594903
crossref_primary_10_1089_lrb_2018_29054_fb
crossref_primary_10_1002_adhm_202303351
crossref_primary_10_3390_ijms25031513
crossref_primary_10_3390_ijms24010009
crossref_primary_10_1038_s41598_020_66145_z
crossref_primary_10_1088_1758_5090_ad3a15
crossref_primary_10_1016_j_addr_2022_114111
crossref_primary_10_1111_micc_12802
crossref_primary_10_3389_fbioe_2022_837693
Cites_doi 10.1038/nmeth.2089
10.1124/jpet.105.089524
10.1007/bf02634255
10.1155/2013/561410
10.1038/nrm1858
10.1073/pnas.242401399
10.1096/fasebj.12.13.1331
10.7554/eLife.10250
10.1084/jem.194.6.797
10.1016/S0002-9440(10)63851-5
10.1016/j.drudis.2012.03.004
10.1038/nature17392
10.1096/fj.01-0868com
10.1126/scitranslmed.3006894
10.1089/ten.tea.2013.0561
10.1038/nrc1951
10.1002/ijc.20865
10.1089/biores.2016.0036
10.3322/caac.21387
10.1016/j.biomaterials.2009.10.049
10.21873/anticanres.11555
10.1038/nmeth.2019
10.1089/ten.tea.2009.0090
10.1002/term.2036
10.1038/s41598-017-03010-6
10.1046/j.1365-2133.2000.03287.x
10.1186/1479-5876-10-1
10.1007/s00432-016-2198-0
10.14573/altex.1604041
10.1007/978-1-4939-3628-1_5
10.1038/bjc.2016.332
10.1073/pnas.1617037114
10.1089/ten.tea.2010.0189
10.1080/09205063.2017.1338502
10.1111/j.1549-8719.2010.00074.x
10.1016/j.addr.2014.03.001
10.1007/s10585-012-9511-3
10.1016/j.biotechadv.2015.12.004
10.1016/j.biomaterials.2015.11.027
10.1089/ten.tea.2009.0473
10.1007/s10456-004-6315-3
10.1089/ten.tea.2016.0296
10.1016/j.jaad.2017.04.1126
10.1038/onc.2011.425
10.1038/nprot.2017.025
10.2967/jnumed.117.192534
10.1089/ten.teb.2010.0315
10.1038/nrd.2016.175
10.1073/pnas.1434429100
10.1038/sj.onc.1210114
10.1007/978-1-4939-1050-2_3
10.1002/jcp.1041380103
10.1007/978-1-59745-060-7_15
10.1038/jid.2011.275
10.1097/01.ASW.0000433102.48268.2a
10.1038/cddis.2013.249
10.1023/B:CLIN.0000006824.41376.b0
10.1371/journal.pone.0092511
10.1002/cam4.726
10.1186/s12885-015-1481-9
10.1038/srep44045
10.1111/j.1600-6143.2005.00790.x
10.1093/aje/kww148
10.1158/1535-7163.MCT-15-0394
10.1039/C5IB00085H
10.1016/j.biomaterials.2007.02.030
10.1126/scisignal.aai8288
10.1016/j.biomaterials.2017.08.041
10.1002/adhm.201600889
10.1002/adhm.201700196
10.1016/j.tibtech.2017.06.015
ContentType Journal Article
Copyright The Author(s) 2018
2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2018
– notice: 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.1038/s41598-018-31502-6
DatabaseName Springer_OA刊
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
ProQuest Science Journals
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE

CrossRef

MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: Springer_OA刊
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 13
ExternalDocumentID 10_1038_s41598_018_31502_6
30181613
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ADBBV
ADRAZ
AENEX
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IPNFZ
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNT
RNTTT
RPM
SNYQT
UKHRP
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
AFPKN
CITATION
7XB
8FK
K9.
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c511t-7fb08725c94af36641435da3ebeaecbb5262e24dde3896b659208330e5ecc8183
IEDL.DBID RPM
ISSN 2045-2322
IngestDate Tue Sep 17 21:21:32 EDT 2024
Tue Aug 27 04:49:43 EDT 2024
Thu Oct 10 22:01:26 EDT 2024
Fri Aug 23 01:03:54 EDT 2024
Sun Oct 13 09:24:20 EDT 2024
Fri Oct 11 20:36:25 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c511t-7fb08725c94af36641435da3ebeaecbb5262e24dde3896b659208330e5ecc8183
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-4031-6133
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123405/
PMID 30181613
PQID 2099430169
PQPubID 2041939
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6123405
proquest_miscellaneous_2099895890
proquest_journals_2099430169
crossref_primary_10_1038_s41598_018_31502_6
pubmed_primary_30181613
springer_journals_10_1038_s41598_018_31502_6
PublicationCentury 2000
PublicationDate 2018-09-04
PublicationDateYYYYMMDD 2018-09-04
PublicationDate_xml – month: 09
  year: 2018
  text: 2018-09-04
  day: 04
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2018
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Kaur (CR32) 2016; 532
Ghiasvand (CR2) 2017; 185
Hill (CR9) 2015; 14
Beaudoin Cloutier (CR35) 2017; 23
Pisano, Triacca, Barbee, Swartz (CR27) 2015; 7
Griffith, Swartz (CR47) 2006; 7
Horvath (CR6) 2016; 15
Supp, Wilson-Landy, Boyce (CR22) 2002; 16
Volpe, Klufas, Hegde, Grant-Kels (CR37) 2017; 77
Chi (CR41) 2003; 100
Marino, Luginbühl, Scola, Meuli, Reichmann (CR8) 2014; 6
Cheli (CR48) 2012; 31
Magdeldin (CR31) 2017; 7
Tang (CR51) 2017; 28
Schindelin (CR75) 2012; 9
Gibot (CR25) 2016; 78
Ascierto (CR38) 2012; 10
Amann (CR44) 2017; 7
Eves (CR13) 2000; 142
Laschke, Menger (CR18) 2016; 34
Anastasov (CR4) 2015; 15
Hagemann (CR63) 2017; 37
Gibot, Galbraith, Huot, Auger (CR16) 2013; 30
CR45
Eves (CR12) 2003; 20
Gibot, Galbraith, Huot, Auger (CR15) 2010; 16
Podgrabinska (CR28) 2002; 99
Liu (CR20) 2013; 2013
Tremblay, Berthod, Germain, Auger (CR39) 2005; 315
Lokmic (CR29) 2016; 1430
Feldman, Wolfe (CR74) 2014; 1180
Zhao (CR50) 2016; 5
Kaur, Webster, Weeraratna (CR49) 2016; 115
Hendrickx, Vranckx, Luttun (CR23) 2011; 17
Germain (CR70) 1993
Amann (CR42) 2014; 9
Ponec (CR19) 2004; 7
Asthana, Kisaalita (CR46) 2012; 17
Black, Berthod, L’Heureux, Germain, Auger (CR24) 1998; 12
Tremblay, Hudon, Berthod, Germain, Auger (CR40) 2005; 5
Siegel, Miller, Jemal (CR1) 2017; 67
Huber (CR43) 2016; 142
Ong (CR62) 2010; 31
Larouche (CR72) 2016; 5
CR17
Hirakawa (CR26) 2003; 162
Walsh, Cook, Skala (CR64) 2017; 58
CR53
CR52
Larouche (CR73) 2009; 482
Shoemaker (CR5) 2006; 6
Rochon (CR14) 2010; 16
Boa (CR36) 2013; 26
Vermette (CR67) 2007; 28
Ahmadzadeh (CR33) 2017; 114
Schneider, Rasband, Eliceiri (CR76) 2012; 9
Proulx (CR65) 2010; 16
Mak, Evaniew, Ghert (CR3) 2014; 6
Kiowski (CR7) 2012; 132
Emmett, Lanati, Dunn, Stone, Tes (CR55) 2011; 18
Bouhout (CR66) 2010; 16
Chabaud, Rousseau, Marcoux, Bolduc (CR61) 2015; 11
CR69
CR68
Kriehuber (CR56) 2001; 194
Auger (CR71) 1995; 31
Vörsmann (CR11) 2013; 4
Shields (CR54) 2007; 26
Rotolo (CR57) 2005; 115
Groeber (CR10) 2016; 33
Yanez (CR21) 2015; 21
Parekh (CR58) 2016; 5
Gibot (CR30) 2017; 12
Hata, Senoo (CR34) 1989; 138
Flecknell (CR59) 2002; 19
Thoma, Zimmermann, Agarkova, Kelm, Krek (CR60) 2014; 69
H Ahmadzadeh (31502_CR33) 2017; 114
H Vörsmann (31502_CR11) 2013; 4
L Gibot (31502_CR16) 2013; 30
B Hendrickx (31502_CR23) 2011; 17
Y Cheli (31502_CR48) 2012; 31
M Pisano (31502_CR27) 2015; 7
S Hirakawa (31502_CR26) 2003; 162
CA Schneider (31502_CR76) 2012; 9
RH Shoemaker (31502_CR5) 2006; 6
M Vermette (31502_CR67) 2007; 28
S Podgrabinska (31502_CR28) 2002; 99
E Kriehuber (31502_CR56) 2001; 194
P Eves (31502_CR13) 2000; 142
G Kiowski (31502_CR7) 2012; 132
PR Parekh (31502_CR58) 2016; 5
AJ Walsh (31502_CR64) 2017; 58
C Beaudoin Cloutier (31502_CR35) 2017; 23
IW Mak (31502_CR3) 2014; 6
JAN Hagemann (31502_CR63) 2017; 37
31502_CR68
31502_CR69
R Hata (31502_CR34) 1989; 138
O Boa (31502_CR36) 2013; 26
A Asthana (31502_CR46) 2012; 17
D Larouche (31502_CR73) 2009; 482
L Gibot (31502_CR25) 2016; 78
M Ponec (31502_CR19) 2004; 7
MW Laschke (31502_CR18) 2016; 34
Y Liu (31502_CR20) 2013; 2013
M-HH Rochon (31502_CR14) 2010; 16
AF Black (31502_CR24) 1998; 12
31502_CR52
S Bouhout (31502_CR66) 2010; 16
F Groeber (31502_CR10) 2016; 33
J-T Chi (31502_CR41) 2003; 100
31502_CR53
L Gibot (31502_CR30) 2017; 12
LG Griffith (31502_CR47) 2006; 7
P Flecknell (31502_CR59) 2002; 19
S Chabaud (31502_CR61) 2015; 11
S Proulx (31502_CR65) 2010; 16
AT Feldman (31502_CR74) 2014; 1180
31502_CR17
A Kaur (31502_CR49) 2016; 115
T Magdeldin (31502_CR31) 2017; 7
J Schindelin (31502_CR75) 2012; 9
S-M Ong (31502_CR62) 2010; 31
ZI Lokmic (31502_CR29) 2016; 1430
PA Ascierto (31502_CR38) 2012; 10
N Anastasov (31502_CR4) 2015; 15
A Kaur (31502_CR32) 2016; 532
FA Auger (31502_CR71) 1995; 31
P-LL Tremblay (31502_CR40) 2005; 5
A Amann (31502_CR44) 2017; 7
CR Thoma (31502_CR60) 2014; 69
L Germain (31502_CR70) 1993
R Ghiasvand (31502_CR2) 2017; 185
D Larouche (31502_CR72) 2016; 5
A Amann (31502_CR42) 2014; 9
JD Shields (31502_CR54) 2007; 26
31502_CR45
DM Supp (31502_CR22) 2002; 16
MS Emmett (31502_CR55) 2011; 18
L Gibot (31502_CR15) 2010; 16
Y Tang (31502_CR51) 2017; 28
RL Siegel (31502_CR1) 2017; 67
H Zhao (31502_CR50) 2016; 5
P Eves (31502_CR12) 2003; 20
VO Volpe (31502_CR37) 2017; 77
JM Huber (31502_CR43) 2016; 142
M Yanez (31502_CR21) 2015; 21
D Marino (31502_CR8) 2014; 6
S Rotolo (31502_CR57) 2005; 115
P-LL Tremblay (31502_CR39) 2005; 315
P Horvath (31502_CR6) 2016; 15
DS Hill (31502_CR9) 2015; 14
References_xml – ident: CR45
– volume: 9
  start-page: 671
  year: 2012
  end-page: 675
  ident: CR76
  article-title: NIH Image to ImageJ: 25 years of image analysis
  publication-title: Nature methods
  doi: 10.1038/nmeth.2089
  contributor:
    fullname: Eliceiri
– volume: 315
  start-page: 510
  year: 2005
  end-page: 516
  ident: CR39
  article-title: evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue
  publication-title: The Journal of pharmacology and experimental therapeutics
  doi: 10.1124/jpet.105.089524
  contributor:
    fullname: Auger
– volume: 31
  start-page: 432
  year: 1995
  end-page: 439
  ident: CR71
  article-title: Skin equivalent produced with human collagen. cellular & developmental biology
  publication-title: Animal
  doi: 10.1007/bf02634255
  contributor:
    fullname: Auger
– volume: 2013
  start-page: 561410
  year: 2013
  ident: CR20
  article-title: construction of scaffold-free bilayered tissue-engineered skin containing capillary networks
  publication-title: BioMed research international
  doi: 10.1155/2013/561410
  contributor:
    fullname: Liu
– volume: 7
  start-page: 211
  year: 2006
  end-page: 224
  ident: CR47
  article-title: Capturing complex 3D tissue physiology
  publication-title: Nature reviews. Molecular cell biology
  doi: 10.1038/nrm1858
  contributor:
    fullname: Swartz
– ident: CR68
– volume: 99
  start-page: 16069
  year: 2002
  end-page: 16074
  ident: CR28
  article-title: Molecular characterization of lymphatic endothelial cells
  publication-title: Proceedings of the National Academy of Sciences
  doi: 10.1073/pnas.242401399
  contributor:
    fullname: Podgrabinska
– volume: 12
  start-page: 1331
  year: 1998
  end-page: 1340
  ident: CR24
  article-title: reconstruction of a human capillary-like network in a tissue-engineered skin equivalent
  publication-title: FASEB journal: official publication of the Federation of American Societies for Experimental Biology
  doi: 10.1096/fasebj.12.13.1331
  contributor:
    fullname: Auger
– volume: 5
  start-page: e10250
  year: 2016
  ident: CR50
  article-title: Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
  publication-title: eLife
  doi: 10.7554/eLife.10250
  contributor:
    fullname: Zhao
– volume: 194
  start-page: 797
  year: 2001
  end-page: 808
  ident: CR56
  article-title: Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
  publication-title: The Journal of experimental medicine
  doi: 10.1084/jem.194.6.797
  contributor:
    fullname: Kriehuber
– volume: 16
  start-page: 2192
  year: 2010
  end-page: 2201
  ident: CR65
  article-title: Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types
  publication-title: Molecular vision
  contributor:
    fullname: Proulx
– volume: 162
  start-page: 575
  year: 2003
  end-page: 586
  ident: CR26
  article-title: Identification of vascular lineage- specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells
  publication-title: American Journal of Pathology
  doi: 10.1016/S0002-9440(10)63851-5
  contributor:
    fullname: Hirakawa
– volume: 17
  start-page: 810
  year: 2012
  end-page: 817
  ident: CR46
  article-title: Microtissue size and hypoxia in HTS with 3D cultures
  publication-title: Drug Discovery Today
  doi: 10.1016/j.drudis.2012.03.004
  contributor:
    fullname: Kisaalita
– volume: 532
  start-page: 250
  year: 2016
  end-page: 254
  ident: CR32
  article-title: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
  publication-title: Nature
  doi: 10.1038/nature17392
  contributor:
    fullname: Kaur
– volume: 16
  start-page: 797
  year: 2002
  end-page: 804
  ident: CR22
  article-title: Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice
  publication-title: FASEB journal: official publication of the Federation of American Societies for Experimental Biology
  doi: 10.1096/fj.01-0868com
  contributor:
    fullname: Boyce
– volume: 6
  start-page: 221ra214
  year: 2014
  ident: CR8
  article-title: Bioengineering dermo-epidermal skin grafts with blood and lymphatic capillaries
  publication-title: Science Translational Medicine
  doi: 10.1126/scitranslmed.3006894
  contributor:
    fullname: Reichmann
– volume: 21
  start-page: 224
  year: 2015
  end-page: 233
  ident: CR21
  article-title: assessment of printed microvasculature in a bilayer skin graft to treat full-thickness wounds
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2013.0561
  contributor:
    fullname: Yanez
– volume: 6
  start-page: 813
  year: 2006
  end-page: 823
  ident: CR5
  article-title: The NCI60 human tumour cell line anticancer drug screen
  publication-title: Nature reviews. Cancer
  doi: 10.1038/nrc1951
  contributor:
    fullname: Shoemaker
– volume: 115
  start-page: 164
  year: 2005
  end-page: 169
  ident: CR57
  article-title: Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild‐type INK4A in melanoma cells
  publication-title: International Journal of Cancer
  doi: 10.1002/ijc.20865
  contributor:
    fullname: Rotolo
– volume: 5
  start-page: 320
  year: 2016
  end-page: 329
  ident: CR72
  article-title: Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries
  publication-title: BioResearch open access
  doi: 10.1089/biores.2016.0036
  contributor:
    fullname: Larouche
– volume: 67
  start-page: 7
  year: 2017
  end-page: 30
  ident: CR1
  article-title: Cancer statistics, 2017
  publication-title: CA: A Cancer Journal for Clinicians
  doi: 10.3322/caac.21387
  contributor:
    fullname: Jemal
– volume: 31
  start-page: 1180
  year: 2010
  end-page: 1190
  ident: CR62
  article-title: Engineering a scaffold-free 3D tumor model for drug penetration studies
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2009.10.049
  contributor:
    fullname: Ong
– volume: 37
  start-page: 2201
  year: 2017
  end-page: 2210
  ident: CR63
  article-title: Spheroid-based 3D Cell Cultures Enable Personalized Therapy Testing and Drug Discovery in Head and Neck Cancer
  publication-title: Anticancer Research
  doi: 10.21873/anticanres.11555
  contributor:
    fullname: Hagemann
– volume: 9
  start-page: 676
  year: 2012
  end-page: 682
  ident: CR75
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nature methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: Schindelin
– volume: 16
  start-page: 1457
  year: 2010
  end-page: 1468
  ident: CR14
  article-title: Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2009.0090
  contributor:
    fullname: Rochon
– volume: 11
  start-page: 1377
  year: 2015
  end-page: 1389
  ident: CR61
  article-title: Inexpensive production of near-native engineered stromas
  publication-title: Journal of tissue engineering and regenerative medicine
  doi: 10.1002/term.2036
  contributor:
    fullname: Bolduc
– volume: 7
  year: 2017
  ident: CR44
  article-title: Development of a 3D angiogenesis model to study tumour – endothelial cell interactions and the effects of anti-angiogenic drugs
  publication-title: Scientific Reports
  doi: 10.1038/s41598-017-03010-6
  contributor:
    fullname: Amann
– start-page: 99
  year: 1993
  end-page: 104
  ident: CR70
  article-title: Improvement of human keratinocyte isolation and culture using thermolysin
  publication-title: Burns: journal of the International Society for Burn Injuries
  contributor:
    fullname: Germain
– volume: 142
  start-page: 210
  year: 2000
  end-page: 222
  ident: CR13
  article-title: Characterization of an model of human melanoma invasion based on reconstructed human skin
  publication-title: The British journal of dermatology
  doi: 10.1046/j.1365-2133.2000.03287.x
  contributor:
    fullname: Eves
– volume: 10
  start-page: 1
  year: 2012
  end-page: 9
  ident: CR38
  article-title: The role of BRAF V600 mutation in melanoma
  publication-title: Journal of Translational Medicine
  doi: 10.1186/1479-5876-10-1
  contributor:
    fullname: Ascierto
– volume: 142
  start-page: 1955
  year: 2016
  end-page: 1966
  ident: CR43
  article-title: Evaluation of assays for drug efficacy in a three-dimensional model of the lung
  publication-title: Journal of cancer research and clinical oncology
  doi: 10.1007/s00432-016-2198-0
  contributor:
    fullname: Huber
– volume: 33
  start-page: 415
  year: 2016
  end-page: 422
  ident: CR10
  article-title: A first vascularized skin equivalent for as an alternative to animal experimentation
  publication-title: ALTEX
  doi: 10.14573/altex.1604041
  contributor:
    fullname: Groeber
– volume: 1430
  start-page: 77
  year: 2016
  end-page: 90
  ident: CR29
  article-title: Identification, and Culture of Human Lymphatic Endothelial Cells
  publication-title: Methods in molecular biology (Clifton, N.J.)
  doi: 10.1007/978-1-4939-3628-1_5
  contributor:
    fullname: Lokmic
– volume: 115
  start-page: 1273
  year: 2016
  end-page: 1279
  ident: CR49
  article-title: In the Wnt-er of life: Wnt signalling in melanoma and ageing
  publication-title: British Journal of Cancer
  doi: 10.1038/bjc.2016.332
  contributor:
    fullname: Weeraratna
– volume: 114
  start-page: E1617
  year: 2017
  end-page: E1626
  ident: CR33
  article-title: Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1617037114
  contributor:
    fullname: Ahmadzadeh
– volume: 16
  start-page: 3199
  year: 2010
  end-page: 3206
  ident: CR15
  article-title: A preexisting microvascular network benefits revascularization of a microvascularized tissue-engineered skin substitute
  publication-title: Tissue Eng Part A
  doi: 10.1089/ten.tea.2010.0189
  contributor:
    fullname: Auger
– volume: 28
  start-page: 1603
  year: 2017
  end-page: 1616
  ident: CR51
  article-title: Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy
  publication-title: Journal of Biomaterials Science, Polymer Edition
  doi: 10.1080/09205063.2017.1338502
  contributor:
    fullname: Tang
– volume: 18
  start-page: 172
  year: 2011
  end-page: 182
  ident: CR55
  article-title: CCR7 Mediates Directed Growth of Melanomas Towards Lymphatics
  publication-title: Microcirculation
  doi: 10.1111/j.1549-8719.2010.00074.x
  contributor:
    fullname: Tes
– volume: 69
  start-page: 29
  year: 2014
  end-page: 41
  ident: CR60
  article-title: 3D cell culture systems modeling tumor growth determinants in cancer target discovery
  publication-title: Advanced Drug Delivery Reviews
  doi: 10.1016/j.addr.2014.03.001
  contributor:
    fullname: Krek
– volume: 30
  start-page: 83
  year: 2013
  end-page: 90
  ident: CR16
  article-title: Development of a tridimensional microvascularized human skin substitute to study melanoma biology
  publication-title: Clin Exp Metastasis
  doi: 10.1007/s10585-012-9511-3
  contributor:
    fullname: Auger
– volume: 34
  start-page: 112
  year: 2016
  end-page: 121
  ident: CR18
  article-title: Prevascularization in tissue engineering: Current concepts and future directions
  publication-title: Biotechnology advances
  doi: 10.1016/j.biotechadv.2015.12.004
  contributor:
    fullname: Menger
– volume: 78
  start-page: 129
  year: 2016
  end-page: 139
  ident: CR25
  article-title: Cell-based approach for 3D reconstruction of lymphatic capillaries reveals distinct functions of HGF and VEGF-C in lymphangiogenesis
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.11.027
  contributor:
    fullname: Gibot
– volume: 16
  start-page: 1539
  year: 2010
  end-page: 1548
  ident: CR66
  article-title: reconstruction of an autologous, watertight, and resistant vesical equivalent
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2009.0473
  contributor:
    fullname: Bouhout
– volume: 7
  start-page: 295
  year: 2004
  end-page: 305
  ident: CR19
  article-title: Endothelial network formed with human dermal microvascular endothelial cells in autologous multicellular skin substitutes
  publication-title: Angiogenesis
  doi: 10.1007/s10456-004-6315-3
  contributor:
    fullname: Ponec
– volume: 23
  start-page: 313
  year: 2017
  end-page: 322
  ident: CR35
  article-title: Evaluation and Imaging of a Bilayered Self-Assembled Skin Substitute Using a Decellularized Dermal Matrix Grafted on Mice
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2016.0296
  contributor:
    fullname: Beaudoin Cloutier
– volume: 77
  start-page: 356
  year: 2017
  end-page: 368
  ident: CR37
  article-title: The new paradigm of systemic therapies for metastatic melanoma
  publication-title: Journal of the American Academy of Dermatology
  doi: 10.1016/j.jaad.2017.04.1126
  contributor:
    fullname: Grant-Kels
– volume: 31
  start-page: 2461
  year: 2012
  end-page: 2470
  ident: CR48
  article-title: Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells
  publication-title: Oncogene
  doi: 10.1038/onc.2011.425
  contributor:
    fullname: Cheli
– ident: CR53
– volume: 12
  start-page: 1077
  year: 2017
  end-page: 1088
  ident: CR30
  article-title: Tissue-engineered 3D human lymphatic microvascular network for studies of lymphangiogenesis
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2017.025
  contributor:
    fullname: Gibot
– volume: 58
  start-page: 1367
  year: 2017
  end-page: 1372
  ident: CR64
  article-title: Functional Optical Imaging of Primary Human Tumor Organoids for Personalized Drug Screens
  publication-title: Journal of Nuclear Medicine
  doi: 10.2967/jnumed.117.192534
  contributor:
    fullname: Skala
– volume: 17
  start-page: 13
  year: 2011
  end-page: 24
  ident: CR23
  article-title: Cell-based vascularization strategies for skin tissue engineering
  publication-title: Tissue engineering. Part B, Reviews
  doi: 10.1089/ten.teb.2010.0315
  contributor:
    fullname: Luttun
– volume: 15
  start-page: 751
  year: 2016
  end-page: 769
  ident: CR6
  article-title: Screening out irrelevant cell-based models of disease
  publication-title: Nature reviews. Drug discovery
  doi: 10.1038/nrd.2016.175
  contributor:
    fullname: Horvath
– volume: 100
  start-page: 10623
  year: 2003
  end-page: 10628
  ident: CR41
  article-title: Endothelial cell diversity revealed by global expression profiling
  publication-title: Proceedings of the National Academy of Sciences
  doi: 10.1073/pnas.1434429100
  contributor:
    fullname: Chi
– ident: CR69
– volume: 26
  start-page: 2997
  year: 2007
  end-page: 3005
  ident: CR54
  article-title: Chemokine-mediated migration of melanoma cells towards lymphatics–a mechanism contributing to metastasis
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210114
  contributor:
    fullname: Shields
– volume: 1180
  start-page: 31
  year: 2014
  end-page: 43
  ident: CR74
  article-title: Tissue processing and hematoxylin and eosin staining
  publication-title: Methods in molecular biology (Clifton, N.J.)
  doi: 10.1007/978-1-4939-1050-2_3
  contributor:
    fullname: Wolfe
– ident: CR52
– ident: CR17
– volume: 138
  start-page: 8
  year: 1989
  end-page: 16
  ident: CR34
  article-title: L-ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissuelike substance by skin fibroblasts
  publication-title: Journal of cellular physiology
  doi: 10.1002/jcp.1041380103
  contributor:
    fullname: Senoo
– volume: 482
  start-page: 233
  year: 2009
  end-page: 256
  ident: CR73
  article-title: Regeneration of skin and cornea by tissue engineering
  publication-title: Methods in molecular biology (Clifton, N.J.)
  doi: 10.1007/978-1-59745-060-7_15
  contributor:
    fullname: Larouche
– volume: 132
  start-page: 144
  year: 2012
  end-page: 153
  ident: CR7
  article-title: Engineering melanoma progression in a humanized environment
  publication-title: The Journal of investigative dermatology
  doi: 10.1038/jid.2011.275
  contributor:
    fullname: Kiowski
– volume: 26
  start-page: 400
  year: 2013
  end-page: 409
  ident: CR36
  article-title: Prospective study on the treatment of lower-extremity chronic venous and mixed ulcers using tissue-engineered skin substitute made by the self-assembly approach
  publication-title: Advances in skin & wound care
  doi: 10.1097/01.ASW.0000433102.48268.2a
  contributor:
    fullname: Boa
– volume: 4
  start-page: e719
  year: 2013
  ident: CR11
  article-title: Development of a human three-dimensional organotypic skin-melanoma spheroid model for drug testing
  publication-title: Cell Death & Disease
  doi: 10.1038/cddis.2013.249
  contributor:
    fullname: Vörsmann
– volume: 20
  start-page: 685
  year: 2003
  end-page: 700
  ident: CR12
  article-title: Melanoma invasion in reconstructed human skin is influenced by skin cells–investigation of the role of proteolytic enzymes
  publication-title: Clinical & experimental metastasis
  doi: 10.1023/B:CLIN.0000006824.41376.b0
  contributor:
    fullname: Eves
– volume: 9
  start-page: e92511
  year: 2014
  ident: CR42
  article-title: Development of an innovative 3D cell culture system to study tumour-stroma interactions in non-small cell lung cancer cells
  publication-title: PloS one
  doi: 10.1371/journal.pone.0092511
  contributor:
    fullname: Amann
– volume: 5
  start-page: 1731
  year: 2016
  end-page: 1741
  ident: CR58
  article-title: Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model
  publication-title: Cancer Medicine
  doi: 10.1002/cam4.726
  contributor:
    fullname: Parekh
– volume: 6
  start-page: 114
  year: 2014
  end-page: 118
  ident: CR3
  article-title: Lost in translation: animal models and clinical trials in cancer treatment
  publication-title: American journal of translational research
  contributor:
    fullname: Ghert
– volume: 15
  year: 2015
  ident: CR4
  article-title: A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment
  publication-title: BMC cancer
  doi: 10.1186/s12885-015-1481-9
  contributor:
    fullname: Anastasov
– volume: 7
  year: 2017
  ident: CR31
  article-title: Engineering a vascularised 3D model of cancer progression
  publication-title: Scientific Reports
  doi: 10.1038/srep44045
  contributor:
    fullname: Magdeldin
– volume: 5
  start-page: 1002
  year: 2005
  end-page: 1010
  ident: CR40
  article-title: Inosculation of tissue-engineered capillaries with the host’s vasculature in a reconstructed skin transplanted on mice
  publication-title: American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  doi: 10.1111/j.1600-6143.2005.00790.x
  contributor:
    fullname: Auger
– volume: 185
  start-page: 147
  year: 2017
  end-page: 156
  ident: CR2
  article-title: Indoor Tanning and Melanoma Risk: Long-Term Evidence From a Prospective Population-Based Cohort Study
  publication-title: American Journal of Epidemiology
  doi: 10.1093/aje/kww148
  contributor:
    fullname: Ghiasvand
– volume: 19
  start-page: 73
  year: 2002
  end-page: 78
  ident: CR59
  article-title: Replacement, reduction and refinement
  publication-title: ALTEX
  contributor:
    fullname: Flecknell
– volume: 14
  start-page: 2665
  year: 2015
  end-page: 2673
  ident: CR9
  article-title: A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-15-0394
  contributor:
    fullname: Hill
– volume: 7
  start-page: 525
  year: 2015
  end-page: 533
  ident: CR27
  article-title: An model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion
  publication-title: Integrative biology: quantitative biosciences from nano to macro
  doi: 10.1039/C5IB00085H
  contributor:
    fullname: Swartz
– volume: 28
  start-page: 2850
  year: 2007
  end-page: 2860
  ident: CR67
  article-title: Production of a new tissue-engineered adipose substitute from human adipose-derived stromal cells
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2007.02.030
  contributor:
    fullname: Vermette
– volume: 16
  start-page: 1457
  year: 2010
  ident: 31502_CR14
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2009.0090
  contributor:
    fullname: M-HH Rochon
– ident: 31502_CR53
  doi: 10.1126/scisignal.aai8288
– volume: 114
  start-page: E1617
  year: 2017
  ident: 31502_CR33
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1617037114
  contributor:
    fullname: H Ahmadzadeh
– ident: 31502_CR69
  doi: 10.1016/j.biomaterials.2017.08.041
– start-page: 99
  volume-title: Burns: journal of the International Society for Burn Injuries
  year: 1993
  ident: 31502_CR70
  contributor:
    fullname: L Germain
– volume: 17
  start-page: 13
  year: 2011
  ident: 31502_CR23
  publication-title: Tissue engineering. Part B, Reviews
  doi: 10.1089/ten.teb.2010.0315
  contributor:
    fullname: B Hendrickx
– volume: 142
  start-page: 1955
  year: 2016
  ident: 31502_CR43
  publication-title: Journal of cancer research and clinical oncology
  doi: 10.1007/s00432-016-2198-0
  contributor:
    fullname: JM Huber
– volume: 162
  start-page: 575
  year: 2003
  ident: 31502_CR26
  publication-title: American Journal of Pathology
  doi: 10.1016/S0002-9440(10)63851-5
  contributor:
    fullname: S Hirakawa
– volume: 6
  start-page: 114
  year: 2014
  ident: 31502_CR3
  publication-title: American journal of translational research
  contributor:
    fullname: IW Mak
– volume: 7
  year: 2017
  ident: 31502_CR31
  publication-title: Scientific Reports
  doi: 10.1038/srep44045
  contributor:
    fullname: T Magdeldin
– volume: 1430
  start-page: 77
  year: 2016
  ident: 31502_CR29
  publication-title: Methods in molecular biology (Clifton, N.J.)
  doi: 10.1007/978-1-4939-3628-1_5
  contributor:
    fullname: ZI Lokmic
– volume: 12
  start-page: 1331
  year: 1998
  ident: 31502_CR24
  publication-title: FASEB journal: official publication of the Federation of American Societies for Experimental Biology
  doi: 10.1096/fasebj.12.13.1331
  contributor:
    fullname: AF Black
– volume: 21
  start-page: 224
  year: 2015
  ident: 31502_CR21
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2013.0561
  contributor:
    fullname: M Yanez
– volume: 7
  start-page: 211
  year: 2006
  ident: 31502_CR47
  publication-title: Nature reviews. Molecular cell biology
  doi: 10.1038/nrm1858
  contributor:
    fullname: LG Griffith
– volume: 17
  start-page: 810
  year: 2012
  ident: 31502_CR46
  publication-title: Drug Discovery Today
  doi: 10.1016/j.drudis.2012.03.004
  contributor:
    fullname: A Asthana
– volume: 315
  start-page: 510
  year: 2005
  ident: 31502_CR39
  publication-title: The Journal of pharmacology and experimental therapeutics
  doi: 10.1124/jpet.105.089524
  contributor:
    fullname: P-LL Tremblay
– volume: 7
  start-page: 295
  year: 2004
  ident: 31502_CR19
  publication-title: Angiogenesis
  doi: 10.1007/s10456-004-6315-3
  contributor:
    fullname: M Ponec
– volume: 5
  start-page: 320
  year: 2016
  ident: 31502_CR72
  publication-title: BioResearch open access
  doi: 10.1089/biores.2016.0036
  contributor:
    fullname: D Larouche
– volume: 19
  start-page: 73
  year: 2002
  ident: 31502_CR59
  publication-title: ALTEX
  contributor:
    fullname: P Flecknell
– volume: 15
  year: 2015
  ident: 31502_CR4
  publication-title: BMC cancer
  doi: 10.1186/s12885-015-1481-9
  contributor:
    fullname: N Anastasov
– volume: 7
  year: 2017
  ident: 31502_CR44
  publication-title: Scientific Reports
  doi: 10.1038/s41598-017-03010-6
  contributor:
    fullname: A Amann
– volume: 5
  start-page: e10250
  year: 2016
  ident: 31502_CR50
  publication-title: eLife
  doi: 10.7554/eLife.10250
  contributor:
    fullname: H Zhao
– volume: 34
  start-page: 112
  year: 2016
  ident: 31502_CR18
  publication-title: Biotechnology advances
  doi: 10.1016/j.biotechadv.2015.12.004
  contributor:
    fullname: MW Laschke
– volume: 185
  start-page: 147
  year: 2017
  ident: 31502_CR2
  publication-title: American Journal of Epidemiology
  doi: 10.1093/aje/kww148
  contributor:
    fullname: R Ghiasvand
– volume: 15
  start-page: 751
  year: 2016
  ident: 31502_CR6
  publication-title: Nature reviews. Drug discovery
  doi: 10.1038/nrd.2016.175
  contributor:
    fullname: P Horvath
– volume: 16
  start-page: 1539
  year: 2010
  ident: 31502_CR66
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2009.0473
  contributor:
    fullname: S Bouhout
– volume: 142
  start-page: 210
  year: 2000
  ident: 31502_CR13
  publication-title: The British journal of dermatology
  doi: 10.1046/j.1365-2133.2000.03287.x
  contributor:
    fullname: P Eves
– volume: 28
  start-page: 1603
  year: 2017
  ident: 31502_CR51
  publication-title: Journal of Biomaterials Science, Polymer Edition
  doi: 10.1080/09205063.2017.1338502
  contributor:
    fullname: Y Tang
– volume: 11
  start-page: 1377
  year: 2015
  ident: 31502_CR61
  publication-title: Journal of tissue engineering and regenerative medicine
  doi: 10.1002/term.2036
  contributor:
    fullname: S Chabaud
– ident: 31502_CR68
  doi: 10.1002/adhm.201600889
– ident: 31502_CR45
  doi: 10.1002/adhm.201700196
– volume: 31
  start-page: 2461
  year: 2012
  ident: 31502_CR48
  publication-title: Oncogene
  doi: 10.1038/onc.2011.425
  contributor:
    fullname: Y Cheli
– volume: 115
  start-page: 164
  year: 2005
  ident: 31502_CR57
  publication-title: International Journal of Cancer
  doi: 10.1002/ijc.20865
  contributor:
    fullname: S Rotolo
– volume: 16
  start-page: 2192
  year: 2010
  ident: 31502_CR65
  publication-title: Molecular vision
  contributor:
    fullname: S Proulx
– volume: 33
  start-page: 415
  year: 2016
  ident: 31502_CR10
  publication-title: ALTEX
  doi: 10.14573/altex.1604041
  contributor:
    fullname: F Groeber
– volume: 2013
  start-page: 561410
  year: 2013
  ident: 31502_CR20
  publication-title: BioMed research international
  doi: 10.1155/2013/561410
  contributor:
    fullname: Y Liu
– volume: 10
  start-page: 1
  year: 2012
  ident: 31502_CR38
  publication-title: Journal of Translational Medicine
  doi: 10.1186/1479-5876-10-1
  contributor:
    fullname: PA Ascierto
– volume: 16
  start-page: 3199
  year: 2010
  ident: 31502_CR15
  publication-title: Tissue Eng Part A
  doi: 10.1089/ten.tea.2010.0189
  contributor:
    fullname: L Gibot
– volume: 7
  start-page: 525
  year: 2015
  ident: 31502_CR27
  publication-title: Integrative biology: quantitative biosciences from nano to macro
  doi: 10.1039/C5IB00085H
  contributor:
    fullname: M Pisano
– volume: 9
  start-page: e92511
  year: 2014
  ident: 31502_CR42
  publication-title: PloS one
  doi: 10.1371/journal.pone.0092511
  contributor:
    fullname: A Amann
– volume: 28
  start-page: 2850
  year: 2007
  ident: 31502_CR67
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2007.02.030
  contributor:
    fullname: M Vermette
– volume: 78
  start-page: 129
  year: 2016
  ident: 31502_CR25
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.11.027
  contributor:
    fullname: L Gibot
– volume: 132
  start-page: 144
  year: 2012
  ident: 31502_CR7
  publication-title: The Journal of investigative dermatology
  doi: 10.1038/jid.2011.275
  contributor:
    fullname: G Kiowski
– volume: 6
  start-page: 221ra214
  year: 2014
  ident: 31502_CR8
  publication-title: Science Translational Medicine
  doi: 10.1126/scitranslmed.3006894
  contributor:
    fullname: D Marino
– volume: 99
  start-page: 16069
  year: 2002
  ident: 31502_CR28
  publication-title: Proceedings of the National Academy of Sciences
  doi: 10.1073/pnas.242401399
  contributor:
    fullname: S Podgrabinska
– volume: 77
  start-page: 356
  year: 2017
  ident: 31502_CR37
  publication-title: Journal of the American Academy of Dermatology
  doi: 10.1016/j.jaad.2017.04.1126
  contributor:
    fullname: VO Volpe
– volume: 58
  start-page: 1367
  year: 2017
  ident: 31502_CR64
  publication-title: Journal of Nuclear Medicine
  doi: 10.2967/jnumed.117.192534
  contributor:
    fullname: AJ Walsh
– volume: 194
  start-page: 797
  year: 2001
  ident: 31502_CR56
  publication-title: The Journal of experimental medicine
  doi: 10.1084/jem.194.6.797
  contributor:
    fullname: E Kriehuber
– volume: 67
  start-page: 7
  year: 2017
  ident: 31502_CR1
  publication-title: CA: A Cancer Journal for Clinicians
  doi: 10.3322/caac.21387
  contributor:
    fullname: RL Siegel
– volume: 5
  start-page: 1002
  year: 2005
  ident: 31502_CR40
  publication-title: American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  doi: 10.1111/j.1600-6143.2005.00790.x
  contributor:
    fullname: P-LL Tremblay
– volume: 69
  start-page: 29
  year: 2014
  ident: 31502_CR60
  publication-title: Advanced Drug Delivery Reviews
  doi: 10.1016/j.addr.2014.03.001
  contributor:
    fullname: CR Thoma
– volume: 26
  start-page: 2997
  year: 2007
  ident: 31502_CR54
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210114
  contributor:
    fullname: JD Shields
– volume: 5
  start-page: 1731
  year: 2016
  ident: 31502_CR58
  publication-title: Cancer Medicine
  doi: 10.1002/cam4.726
  contributor:
    fullname: PR Parekh
– volume: 100
  start-page: 10623
  year: 2003
  ident: 31502_CR41
  publication-title: Proceedings of the National Academy of Sciences
  doi: 10.1073/pnas.1434429100
  contributor:
    fullname: J-T Chi
– volume: 4
  start-page: e719
  year: 2013
  ident: 31502_CR11
  publication-title: Cell Death & Disease
  doi: 10.1038/cddis.2013.249
  contributor:
    fullname: H Vörsmann
– volume: 12
  start-page: 1077
  year: 2017
  ident: 31502_CR30
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2017.025
  contributor:
    fullname: L Gibot
– volume: 31
  start-page: 1180
  year: 2010
  ident: 31502_CR62
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2009.10.049
  contributor:
    fullname: S-M Ong
– volume: 20
  start-page: 685
  year: 2003
  ident: 31502_CR12
  publication-title: Clinical & experimental metastasis
  doi: 10.1023/B:CLIN.0000006824.41376.b0
  contributor:
    fullname: P Eves
– volume: 138
  start-page: 8
  year: 1989
  ident: 31502_CR34
  publication-title: Journal of cellular physiology
  doi: 10.1002/jcp.1041380103
  contributor:
    fullname: R Hata
– volume: 115
  start-page: 1273
  year: 2016
  ident: 31502_CR49
  publication-title: British Journal of Cancer
  doi: 10.1038/bjc.2016.332
  contributor:
    fullname: A Kaur
– volume: 23
  start-page: 313
  year: 2017
  ident: 31502_CR35
  publication-title: Tissue engineering. Part A
  doi: 10.1089/ten.tea.2016.0296
  contributor:
    fullname: C Beaudoin Cloutier
– volume: 9
  start-page: 676
  year: 2012
  ident: 31502_CR75
  publication-title: Nature methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: J Schindelin
– volume: 37
  start-page: 2201
  year: 2017
  ident: 31502_CR63
  publication-title: Anticancer Research
  doi: 10.21873/anticanres.11555
  contributor:
    fullname: JAN Hagemann
– ident: 31502_CR52
  doi: 10.1016/j.tibtech.2017.06.015
– volume: 532
  start-page: 250
  year: 2016
  ident: 31502_CR32
  publication-title: Nature
  doi: 10.1038/nature17392
  contributor:
    fullname: A Kaur
– volume: 14
  start-page: 2665
  year: 2015
  ident: 31502_CR9
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-15-0394
  contributor:
    fullname: DS Hill
– ident: 31502_CR17
– volume: 9
  start-page: 671
  year: 2012
  ident: 31502_CR76
  publication-title: Nature methods
  doi: 10.1038/nmeth.2089
  contributor:
    fullname: CA Schneider
– volume: 6
  start-page: 813
  year: 2006
  ident: 31502_CR5
  publication-title: Nature reviews. Cancer
  doi: 10.1038/nrc1951
  contributor:
    fullname: RH Shoemaker
– volume: 31
  start-page: 432
  year: 1995
  ident: 31502_CR71
  publication-title: Animal
  doi: 10.1007/bf02634255
  contributor:
    fullname: FA Auger
– volume: 482
  start-page: 233
  year: 2009
  ident: 31502_CR73
  publication-title: Methods in molecular biology (Clifton, N.J.)
  doi: 10.1007/978-1-59745-060-7_15
  contributor:
    fullname: D Larouche
– volume: 26
  start-page: 400
  year: 2013
  ident: 31502_CR36
  publication-title: Advances in skin & wound care
  doi: 10.1097/01.ASW.0000433102.48268.2a
  contributor:
    fullname: O Boa
– volume: 18
  start-page: 172
  year: 2011
  ident: 31502_CR55
  publication-title: Microcirculation
  doi: 10.1111/j.1549-8719.2010.00074.x
  contributor:
    fullname: MS Emmett
– volume: 1180
  start-page: 31
  year: 2014
  ident: 31502_CR74
  publication-title: Methods in molecular biology (Clifton, N.J.)
  doi: 10.1007/978-1-4939-1050-2_3
  contributor:
    fullname: AT Feldman
– volume: 30
  start-page: 83
  year: 2013
  ident: 31502_CR16
  publication-title: Clin Exp Metastasis
  doi: 10.1007/s10585-012-9511-3
  contributor:
    fullname: L Gibot
– volume: 16
  start-page: 797
  year: 2002
  ident: 31502_CR22
  publication-title: FASEB journal: official publication of the Federation of American Societies for Experimental Biology
  doi: 10.1096/fj.01-0868com
  contributor:
    fullname: DM Supp
SSID ssj0000529419
Score 2.5168614
Snippet While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro...
While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based in vitro...
Abstract While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery and improve clinical translation, new human cell-based...
SourceID pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 13191
SubjectTerms 13/106
13/107
14/1
14/19
14/34
631/67
631/80
82
Antineoplastic Agents - pharmacology
Apoptosis
Biomaterials
Blood
Capillaries
Cell culture
Cell Line
Cell Line, Tumor
Cell Proliferation - drug effects
Drug development
Drug Development - methods
Drug Screening Assays, Antitumor - methods
Epidermis
Extracellular matrix
Filaggrin
Filaggrin Proteins
Humanities and Social Sciences
Humans
Laminin
Lymphatic Vessels - drug effects
Lymphatic Vessels - pathology
Melanoma
Melanoma - blood supply
Melanoma - drug therapy
Melanoma - pathology
multidisciplinary
Science
Science (multidisciplinary)
Self-assembly
Skin cancer
Skin Neoplasms - blood supply
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Tissue engineering
Tissue Engineering - methods
Tumor Microenvironment - drug effects
Vemurafenib - pharmacology
SummonAdditionalLinks – databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEB58IHgR39YXEbxpsG3StD2JTxbBRUTBi5S0zaqw2133cfDfO5Nmd1lFzx1oM18682VmMgNwbGI8rkkTcx8tJJdxK-Ap0lqufB0nSioRGwro3zdV41nevUQvLuA2cGWVY5toDXXZLShGfkZXPKWg3iHnvU9OU6Mou-pGaMzDYhhIStMuXt40Hx4nURbKY8kgdbdlfJGcDdBj0a2ygMKCEZoDNeuRftHM39WSP1Km1hPdrsKKo5DsosZ8DeZMtQ5L9VDJrw14fbK65MZ1GjQlE9esY9q66nY0s6NvGIVfmS1aZ7oqWfsLQaXerazQPZpDRAdohnyWlf3RGyunlUWb8Hx783TV4G6IAi-QSw153Mr9JA6jIpW6JZSSRJBKLRA8bYo8j0IVmlCilUPqonLKsiIrE76JEFz05mILFqpuZXaAUcWpKnQeECdACR0hvjppBUVa4MFGeXAyVmTWq3tlZDbHLZKsVnuGas-s2jOU3h_rOnP_zSCbouzB0eQx7nhKY-jKdEe1TJJGSep7sF1DM3mdoP5jyFA8iGdAmwhQN-3ZJ9XHu-2qTX1okL16cDqGd_pZf69i9_9V7MFySFvNZqD2YWHYH5kDZDHD_NBt1W9MAe_X
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDLZ4CMQF8aa8FCRuUGibNG0PCCFgmpDGaZO4oCptM0DaujE2if177LTdGI8L56RN68-Jv8SODXCiA9yuCR3YDq6Qtgjarh0hrbWlo4JQCskDTQf6jQdZb4n7R_9xDqpyR6UA33_d2lE9qdagc_7xNr7CCX9ZXBkPL97RCNFFMZdO-nyc4XIeFj3BBWl8o6T7Ra5vLxJuVN6d-f3RFVjmlMTKFDz4aqp-8M-fYZTffKnGRNXWYLXkluy6UIZ1mNP5BiwV1SbHm_DUNEK2dZmCUGeM37Ku7qi811XM1MRhdC7LTDQ7U3nGOmNEm5K6slT1qUAR7awZEl2WDUbPLJuGHG1Bq3bXvKnbZXUFO0WSNbSDduKEgeenkVBtLqUg5pQpjqgqnSaJ70lPewKXP-Q0MiH3K9I17mgfUUczz7dhIe_lehcYhaLKVCUukQXsoXwEXoVtN41S3PFIC04rQcb9IolGbJzfPIwLBGIUeWwQiLH3QSXruNKHmG744qtdGVlwPGnGqUD-DZXr3qjoE0Z-GDkW7BTQTIarMLUgmAFt0oHSbM-25K8vJt02JahBWmvBWQXv9LP-_ou9fw-0DyseKaTxWh3AwnAw0ofIfIbJkVHnTxcg_uY
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer_OA刊
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8NAEB60IngR30arrOBNg0k22SRHqZYi6KmFXmTZJFsV2rT0cei_d2aTpsTqwXMmr5nZnW_nCXCrQzyu-Tq0HdwhbT8cuHaMsNYWjgoj4QseanLov76JTs9_6Qf9sk0O1cLU4vc8epihgaEiMJe8eAGuXrENO4ErHNLglmhV_hSKWPluXNbF_H5r3fZsAMrNvMgfwVFjc9oHsF-CRfZYSPcQtnR-BLvF-MjlMbx3DddsXfYU1BnjT2ykhyofjxQzQ24YOVqZSU9nKs_YcInioy6tLFUTmjhER2WGyJVl08UHy9Y5RCfQaz93Wx27HJdgp4ia5nY4SJwo9II09tWAC-ETFMoURzEpnSZJ4AlPez7uZwhSRELxVMRf3NEBihHtNj-FRj7O9Tkwyi0VqUpcsv5IoQKUpIoGbhqneIQRFtytGCknRVcMaaLZPJIF2yWyXRq2S6RurngtyxUyk1Syi492RWzBTXUZdZsCFirX40VBE8VBFDsWnBWiqV7HqdMYYhELwprQKgLqm12_kn99mv7Z1HEGcaoF9yvxrj_r77-4-B_5Jex5pHom9tSExny60FeIX-bJtVHcb4AV51o
  priority: 102
  providerName: Springer Nature
Title Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development
URI https://link.springer.com/article/10.1038/s41598-018-31502-6
https://www.ncbi.nlm.nih.gov/pubmed/30181613
https://www.proquest.com/docview/2099430169
https://search.proquest.com/docview/2099895890
https://pubmed.ncbi.nlm.nih.gov/PMC6123405
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9swFH-kKYNdxtqtq7cuqLBb68a2ZMk-bmlDKaSU0kIuxciy0hYSJ-TjkP9-78l2-kUvvRiMhGXr96z3k94XwB-rcLsmrPIDXCF9oUahnyKt9WWgVSKF5MrSgf7gUp7fiothPGxB3MTCOKd9kz-elOPJSfn44HwrZxPTbfzEuleDHqUMQaLR3YItxfmzLXqV0DtKRZjWATIBT7oLVFIUSBbSSWCMKwDVLeKUqcpVNXiuj96QzLe-kq8Mpk4P9b_Cl5pAsr_Vi-5Ay5a78KkqKbn-Bnc3biZ9W-cZtAXjp2xix7qcTjRzhW8YHb4y57LOdFmw8RohpcytzOgZVSGi7TNDNsuK-eqeFU9-Rd_htn920zv36xIKvkEmtfTVKA8SFcUmFXrEpRREjwrNETptTZ7HkYxsJHCNQ-Iic7KxIifjgY0RWtTlfA_a5bS0-8DI31QanYfECLCHjhFdnYxCkxrc1kgPjpqJzGZVpozMWbh5klUIZDjlmUMgw94HzVxn9V-zyCiMFx8dytSDw00zyjsZMXRpp6uqT5LGSRp48KOCZjNcg6kH6gVomw6US_tlC4qYy6ldi5QHxw28T6_1_lf8_PBAv-BzRALpTFMH0F7OV_Y30ptl3kGhHqoObP87u7y6xrue7HXcUQFeByLpOHH_DyFF_Hg
link.rule.ids 230,315,733,786,790,870,891,12083,21416,24346,27955,27956,31752,31753,33777,33778,41153,42222,43343,43838,51609,53825,53827,74100,74657
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fT9swED5BEYIXxM8RxsBIvA2LJHac5GliG6gbUE1TkXhBlpO42yRIC20f-O-5c9xWHYLnWEp8n3P-fHf-DuDYpnhckzblIXpILtNexHOktVyFJs2UVCK1FNC_7qj2jfx5m9z6gNvQl1VOfKJz1FW_pBj5KV3xlIK0Q74MHjl1jaLsqm-hsQhLJLmZtWDp63nn1-9plIXyWDLK_W2ZUGSnQ9yx6FZZRGHBBN2Bmt-RXtHM19WS_6VM3U50sQ5rnkKyswbzDViw9SYsN00ln7fgrutsya1XGrQVE9_Zg703df_BMNf6hlH4lbmidWbqit0_I6ik3cpKM6A-RHSAZshnWfU0_sOqWWXRNtxcnHe_tblvosBL5FIjnvaKMEvjpMyl6QmlJBGkyggEz9iyKJJYxTaW6OWQuqiCsqzIykRoEwQXd3OxA626X9tdYFRxqkpTRMQJcIRJEF-T9aIyL_FgowL4PDGkHjRaGdrluEWmG7NrNLt2Ztc4en9ia-3_m6GeoRzA0fQxrnhKY5ja9sfNmCxPsjwM4EMDzfR1gvTHkKEEkM6BNh1AatrzT-p_f52qNunQIHsN4GQC7-yz3p7F3vuzOISVdvf6Sl_96Fx-hNWYlp3LRu1Da_Q0tp-Q0YyKA79sXwDKvPLN
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fT9swED4NpiFeEPvFwmDzpL0xq0ns2MkTQrCKwYb2AFJfkOUkDkwqaaHtA__97hy3VUHbcywlvu9y9_nufAfw1Wk8rkmneYwWkkvdJLxAWstVbHWupBLaUUD_14U6vZJng2wQ6p8moaxybhO9oa5HFcXIe3TFUwrqHdJrQlnE75P-4fie0wQpyrSGcRpr8BK9ZExjHPRAL-ItlNGSSRHuzcQi703Qd9H9soQChBkaBrXqm54Rzud1k0-Sp94n9bdhK5BJdtSh_xpeuPYNvOrGSz6-hetLL1XuQs9BVzNxwu7c0LajO8v8EBxGgVjmy9eZbWs2fER4qYsrq-yYJhLRUZohs2X1w-yG1csao3dw1f9-eXzKwzgFXiGrmnLdlHGu06wqpG2EUpKoUm0FwmhdVZZZqlKXSrR3SGJUSflW5GcidhnCjH5dvIf1dtS6D8Co9lRVtkyIHeAKmyHSNm-SqqjwiKMiOJgL0oy7rhnGZ7tFbjqxGxS78WI3uHpvLmsT_qCJWeIdwZfFY9R9SmjY1o1m3Zq8yPIijmCng2bxOkGdyJCrRKBXQFssoL7aq0_aP7e-vzZ1pEEeG8G3ObzLz_r3Lnb_v4vPsIH6an7-uDj_CJspaZ1PS-3B-vRh5vaR2kzLT15n_wLcvfWK
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tissue-engineered+3D+melanoma+model+with+blood+and+lymphatic+capillaries+for+drug+development&rft.jtitle=Scientific+reports&rft.au=Bourland%2C+Jennifer&rft.au=Fradette%2C+Julie&rft.au=Auger%2C+Fran%C3%A7ois+A.&rft.date=2018-09-04&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=8&rft_id=info:doi/10.1038%2Fs41598-018-31502-6&rft_id=info%3Apmid%2F30181613&rft.externalDBID=PMC6123405
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon