Differences in Gender and Overall Survival for Temperature-Sensitive TP53 Mutations in Gastroesophageal Cancer

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 11; p. 1901
• Main Authors: Shaikh, Danial H., Park, Margaret, Chen, Jiandong, Huang, Jeffrey, Friedman, Mark S., Dam, Aamir N., Luthra, Anjuli K., Cappelle, Saraswathi, Pena, Luis R., Permuth, Jennifer B., Mok, Shaffer R. S.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2024; MDPI
• Subjects: Aged; Body temperature; Cell cycle; Clinical outcomes; Development and progression; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - mortality; Female; Gastric cancer; gastroesophageal cancer; gender differences; Genetic aspects; Histology; Humans; Hypothermia; Hypothesis; Male; Medical prognosis; Middle Aged; Mutation; overall survival; Patient outcomes; Physiological aspects; Prognosis; Sex Factors; Stomach; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - mortality; Survival Analysis; Temperature; temperature-sensitive (TS); TP53 mutations; Tumor proteins; Tumor Suppressor Protein p53 - genetics; Tumors; Florida; overall survival; TP53 mutations; gastroesophageal cancer; gender differences; temperature-sensitive (TS)

Background and Objectives: Temperature-sensitive (TS) mutants of TP53 are thermally unstable, unfolded, and inactive at body temperature but can be refolded and reactivated at sub-physiological temperatures. TS TP53 may be amenable for functional rescue by hypothermia or structure-stabilizing drugs,...