Enrichment of intestinal Lactobacillus by enhanced secretory IgA coating alters glucose homeostasis in P2rx7−/− mice

• Published in: Scientific reports Vol. 9; no. 1; pp. 9315 - 11
• Main Authors: Perruzza, Lisa, Strati, Francesco, Gargari, Giorgio, D’Erchia, Anna Maria, Fosso, Bruno, Pesole, Graziano, Guglielmetti, Simone, Grassi, Fabio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.06.2019; Nature Publishing Group
• Subjects: 45/23; 631/250; 631/250/347; 631/326; 631/326/2565/2134; 64/60; Animals; Body weight; Clonal deletion; Coatings; Colonization; Commensals; Digestive system; Gastrointestinal tract; Glucose - metabolism; Homeostasis; Humanities and Social Sciences; Immunoglobulin A; Immunoglobulin A, Secretory - metabolism; Intestinal microflora; Intestines - immunology; Intestines - microbiology; Lactobacillus; Lactobacillus - physiology; Metabolism; Mice; Microbiota; multidisciplinary; Oral administration; Receptors, Purinergic P2X7 - deficiency; Science; Science (multidisciplinary); Small intestine

The secretory immunoglobulin A (SIgA) in mammalian gut protects the organism from infections and contributes to host physiology by shaping microbiota composition. The mechanisms regulating the adaptive SIgA response towards gut microbes are poorly defined. Deletion of P2rx7 , encoding for the ATP-ga...