Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice

• Published in: Journal of lipid research Vol. 42; no. 2; pp. 170 - 180
• Main Authors: Mardones, P, Quiñones, V, Amigo, L, Moreno, M, Miquel, J F, Schwarz, M, Miettinen, H E, Trigatti, B, Krieger, M, VanPatten, S, Cohen, D E, Rigotti, A
• Format: Journal Article
• Language: English
• Published: United States Elsevier 01.02.2001
• Subjects: Animals; Bile Acids and Salts - metabolism; biliary lipids; Blotting, Northern; CD36 Antigens - genetics; CD36 Antigens - physiology; Cholesterol - blood; Cholesterol - metabolism; cholesterol feeding; HDL; hepatic gene expression; Intestinal Absorption; Liver - metabolism; Male; Membrane Proteins; Mice; Mice, Knockout; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B; sterol synthesis

The scavenger receptor class B type I (SR-BI), which is expressed in the liver and intestine, plays a critical role in cholesterol metabolism in rodents. While hepatic SR-BI expression controls high density lipoprotein (HDL) cholesterol metabolism, intestinal SR-BI has been proposed to facilitate ch...