Volatile organic compounds (VOCs) for the non-invasive detection of pancreatic cancer from urine

• Published in: Talanta (Oxford) Vol. 221; p. 121604
• Main Authors: Daulton, Emma, Wicaksono, Alfian N., Tiele, Akira, Kocher, Hemant M., Debernardi, Silvana, Crnogorac-Jurcevic, Tatjana, Covington, James A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021
• Subjects: adenocarcinoma; area; biomarkers; Chronic pancreatitis (CP); detection; gas chromatography; Gas Chromatography-Mass Spectrometry; GC-IMS; GC-TOF-MS; headspace analysis; Humans; Ion Mobility Spectrometry; Mass Spectrometry; Pancreatic ductal adenocarcinoma (PDAC); pancreatic neoplasms; Pancreatic Neoplasms - diagnosis; pancreatitis; patients; sampling; survival rate; Urinary headspace; urine; volatile organic compounds; Volatile organic compounds (VOCs); Volatile Organic Compounds - analysis; wastes; Urinary headspace; GC-IMS; GC-TOF-MS; Pancreatic ductal adenocarcinoma (PDAC); Chronic pancreatitis (CP); Volatile organic compounds (VOCs)

Pancreatic ductal adenocarcinoma (PDAC) is a particularly challenging cancer, with very low 5-year survival rates. This low survival rate is linked to late stage diagnosis, associated with the lack of approved biomarkers. One approach that is receiving considerable attention is the use of volatile o...