The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

• Published in: The Journal of experimental medicine Vol. 214; no. 7; pp. 1913 - 1923
• Main Authors: Patel, Amit A., Zhang, Yan, Fullerton, James N., Boelen, Lies, Rongvaux, Anthony, Maini, Alexander A., Bigley, Venetia, Flavell, Richard A., Gilroy, Derek W., Asquith, Becca, Macallan, Derek, Yona, Simon
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 03.07.2017; The Rockefeller University Press
• Subjects: Animals; Bone marrow; Bone Marrow Cells - immunology; Cell Differentiation - immunology; Cell fate; Cell Survival - immunology; Cells, Cultured; Deuterium; Deuterium - metabolism; Endotoxemia; Endotoxemia - blood; Endotoxemia - immunology; Fate maps; Flow Cytometry; Homeostasis; Homeostasis - immunology; Human behavior; Humans; Inflammation; Inflammation - blood; Inflammation - immunology; Isotope Labeling - methods; Kinetics; Labeling; Life span; Mice; Monocytes; Monocytes - immunology; Repopulation; Restoration; Steady state; Time Factors

In humans, the monocyte pool comprises three subsets (classical, intermediate, and nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, differentiation, and disappearance are critical to understanding both steady-state homeostasis and inflammatory responses....