Target-specific encoding of response inhibition: increased contribution of AMPA to NMDA receptors at excitatory synapses in the prefrontal cortex

• Published in: The Journal of neuroscience Vol. 30; no. 34; pp. 11493 - 11500
• Main Authors: Hayton, Scott J, Lovett-Barron, Matthew, Dumont, Eric C, Olmstead, Mary C
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 25.08.2010
• Subjects: Animals; Conditioning, Operant - physiology; Excitatory Postsynaptic Potentials - physiology; Male; Neural Inhibition - physiology; Prefrontal Cortex - physiology; Rats; Rats, Long-Evans; Receptors, AMPA - physiology; Receptors, N-Methyl-D-Aspartate - physiology; Synapses - physiology

Impulse control suppresses actions that are inappropriate in one context, but may be beneficial in others. The medial prefrontal cortex (mPFC) mediates this process by providing a top-down signal to inhibit competing responses, although the mechanism by which the mPFC acquires this ability is unknow...