SCF ubiquitin ligases in the maintenance of genome stability

In response to genotoxic stress, eukaryotic cells activate the DNA damage response (DDR), a series of pathways that coordinate cell cycle arrest and DNA repair to prevent deleterious mutations. In addition, cells possess checkpoint mechanisms that prevent aneuploidy by regulating the number of centr...

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Published inTrends in biochemical sciences (Amsterdam. Regular ed.) Vol. 37; no. 2; pp. 66 - 73
Main Authors Silverman, Joshua S., Skaar, Jeffrey R., Pagano, Michele
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2012
Subjects
aneuploidy
Animals
antineoplastic agents
cell cycle checkpoints
centrosomes
chromosome segregation
DDR
DNA Damage
DNA repair
eukaryotic cells
genome
Genomic Instability
genotoxicity
Humans
mutation
proteasome endopeptidase complex
proteins
SKP Cullin F-Box Protein Ligases - chemistry
SKP Cullin F-Box Protein Ligases - genetics
SKP Cullin F-Box Protein Ligases - metabolism
therapeutics
ubiquitin-protein ligase
Ubiquitination - genetics
Online AccessGet full text

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Abstract In response to genotoxic stress, eukaryotic cells activate the DNA damage response (DDR), a series of pathways that coordinate cell cycle arrest and DNA repair to prevent deleterious mutations. In addition, cells possess checkpoint mechanisms that prevent aneuploidy by regulating the number of centrosomes and spindle assembly. Among these mechanisms, ubiquitin-mediated degradation of key proteins has an important role in the regulation of the DDR, centrosome duplication and chromosome segregation. This review discusses the functions of a group of ubiquitin ligases, the SCF (SKP1-CUL1-F-box protein) family, in the maintenance of genome stability. Given that general proteasome inhibitors are currently used as anticancer agents, a better understanding of the ubiquitylation of specific targets by specific ubiquitin ligases may result in improved cancer therapeutics.
AbstractList In response to genotoxic stress, eukaryotic cells activate the DNA damage response (DDR), a series of pathways that coordinate cell cycle arrest and DNA repair to prevent deleterious mutations. In addition, cells possess checkpoint mechanisms that prevent aneuploidy by regulating the number of centrosomes and spindle assembly. Among these mechanisms, ubiquitin-mediated degradation of key proteins has an important role in the regulation of the DDR, centrosome duplication and chromosome segregation. This review discusses the functions of a group of ubiquitin ligases, the SCF (SKP1-CUL1-F-box protein) family, in the maintenance of genome stability. Given that general proteasome inhibitors are currently used as anticancer agents, a better understanding of the ubiquitylation of specific targets by specific ubiquitin ligases may result in improved cancer therapeutics.
In response to genotoxic stress, eukaryotic cells activate the DNA damage response (DDR), a series of pathways that coordinate cell cycle arrest and DNA repair to prevent deleterious mutations. In addition, cells possess checkpoint mechanisms that prevent aneuploidy by regulating the number of centrosomes and the spindle assembly. Among these mechanisms, ubiquitin-mediated degradation of key proteins has an important role in the regulation of the DDR, centrosome duplication and chromosome segregation. This review discusses the functions of a group of ubiquitin ligases, the SCF (SKP1-CUL1-F-box protein) family, in the maintenance of genome stability. Given that general proteasome inhibitors are currently used as anticancer agents, a better understanding of the ubiquitylation of specific targets by specific ubiquitin ligases may result in improved cancer therapeutics.
Author Silverman, Joshua S.
Pagano, Michele
Skaar, Jeffrey R.
AuthorAffiliation 3 Department of Pathology, New York University School of Medicine, 522 First Avenue, Smilow Research Building 1107, New York, NY 10016, USA
2 NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, Smilow Research Building 1107, New York, NY 10016, USA
1 Department of Radiation Oncology, New York University School of Medicine, 522 First Avenue, Smilow Research Building 1107, New York, NY 10016, USA
4 Howard Hughes Medical Institute
AuthorAffiliation_xml – name: 3 Department of Pathology, New York University School of Medicine, 522 First Avenue, Smilow Research Building 1107, New York, NY 10016, USA
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  givenname: Joshua S.
  surname: Silverman
  fullname: Silverman, Joshua S.
  organization: Department of Radiation Oncology, New York University School of Medicine, 522 First Avenue, Smilow Research Building 1107, New York, NY 10016, USA
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  givenname: Jeffrey R.
  surname: Skaar
  fullname: Skaar, Jeffrey R.
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  givenname: Michele
  surname: Pagano
  fullname: Pagano, Michele
  email: Michele.pagano@nyumc.org
  organization: NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, Smilow Research Building 1107, New York, NY 10016, USA
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Cites_doi 10.1038/nature02082
10.1371/journal.pone.0000128
10.1126/science.1160462
10.1038/nbt.1646
10.1074/jbc.M509855200
10.1016/j.febslet.2011.05.056
10.1016/j.molcel.2006.06.013
10.1128/MCB.06570-11
10.1002/jcp.21791
10.1186/1471-2091-8-S1-S9
10.2174/156800911794519734
10.1074/jbc.M110.111518
10.4161/cc.9.3.10513
10.1016/j.molcel.2010.09.019
10.1073/pnas.0501873102
10.1038/35077232
10.1016/S0092-8674(00)00010-6
10.1016/j.semcdb.2011.03.002
10.1016/j.febslet.2010.05.031
10.1016/S1534-5807(03)00154-0
10.1073/pnas.0913813107
10.1016/j.molcel.2009.06.030
10.1016/j.ccr.2008.05.017
10.1007/1-4020-3764-3_14
10.1158/0008-5472.CAN-09-1284
10.1146/annurev.biochem.67.1.425
10.1016/j.ccr.2010.06.015
10.1038/onc.2010.584
10.1242/jcs.068502
10.1128/MCB.05733-11
10.1038/nrm1471
10.1073/pnas.0812256106
10.1016/j.molcel.2006.06.016
10.1128/MCB.22.23.8375-8387.2002
10.1038/nature08467
10.1016/j.cub.2004.09.083
10.1083/jcb.200712027
10.1038/nature07185
10.1016/j.cell.2008.05.043
10.1016/j.molcel.2005.07.019
10.1016/j.jhep.2010.06.009
10.1016/j.cell.2004.06.023
10.1038/nrc1011
10.1083/jcb.200808049
10.1038/nature08011
10.1101/gad.914401
10.1038/nrm2163
10.1073/pnas.0307700101
10.1038/ncb2282
10.1101/gad.1255304
10.1038/nrc2396
10.4161/cc.9.2.10445
10.1074/jbc.M802474200
10.1101/gad.13.17.2242
10.1038/nature07884
10.1101/gad.2021311
10.1016/j.cub.2008.11.037
10.1016/j.ceb.2009.08.004
10.1158/0008-5472.CAN-09-0869
10.1101/gad.8.14.1627
10.1038/nature06780
10.1182/blood-2010-03-272567
10.1038/onc.2010.96
10.1038/ncb1320
10.1038/nature09140
10.1038/nrm1547
10.1073/pnas.0610856104
10.1016/j.molcel.2006.09.007
10.1038/sj.onc.1208278
10.1126/science.1160489
10.1016/j.cub.2006.08.026
10.1111/j.1349-7006.2009.01178.x
10.1126/science.1140321
10.1007/978-1-4419-6199-0_6
10.1038/nature06641
10.1091/mbc.e09-01-0008
10.1101/gad.1157503
10.4161/cc.10.7.15249
10.1128/MCB.01085-08
10.1038/nbt.1645
10.1146/annurev.med.50.1.57
10.1038/ncb1969
10.1146/annurev.biochem.78.101807.093809
10.4161/cc.7.19.6775
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References Guardavaccaro (bib0360) 2008; 452
Bekker-Jensen, Mailand (bib0370) 2011; 585
Melixetian (bib0150) 2009; 11
Pawar (bib0220) 2010; 107
(2011) Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation.
Zimmerman, Erikson (bib0145) 2007; 104
Zhang (bib0300) 2009; 35
Lingle (bib0065) 2005; 570
Milhollen (bib0405) 2010; 116
Cunha-Ferreira (bib0345) 2009; 19
Okabe (bib0215) 2006; 1
Busino (bib0115) 2003; 426
Piva (bib0315) 2002; 22
Zhang (bib0295) 2005; 19
Puklowski (bib0325) 2011; 13
Skaar, Pagano (bib0095) 2009; 21
Inuzuka (bib0175) 2010; 18
Watanabe (bib0275) 2004; 101
Agami, Bernards (bib0200) 2000; 102
Santra (bib0225) 2009; 459
Fang, Zhang (bib0055) 2011; 22
Guderian (bib0350) 2010; 123
D’Angiolella (bib0320) 2010; 466
Westbrook (bib0365) 2008; 452
Derheimer, Kastan (bib0045) 2010; 584
Pontano (bib0255) 2008; 28
Jia, Sun (bib0400) 2011; 11
Orlicky (bib0415) 2010; 28
Barbash (bib0205) 2008; 14
Li, Hao (bib0240) 2010; 285
Macurek (bib0260) 2008; 455
Guardavaccaro (bib0355) 2003; 4
Jin (bib0105) 2004; 18
Barbash (bib0235) 2011; 30
Musacchio, Salmon (bib0050) 2007; 8
Cardozo, Pagano (bib0100) 2004; 5
Sorensen (bib0155) 2010; 9
Hershko, Ciechanover (bib0075) 1998; 67
Korzeniewski (bib0335) 2009; 69
Welcker (bib0390) 2004; 14
Honaker, Piwnica-Worms (bib0135) 2010; 29
Mamely (bib0285) 2006; 16
Petroski, Deshaies (bib0090) 2005; 6
Tanaka, Hirota (bib0060) 2009; 100
Bakkenist, Kastan (bib0040) 2004; 118
Myer (bib0140) 2005; 24
Lukas (bib0195) 1994; 9
Abraham (bib0020) 2001; 15
Bassermann (bib0265) 2008; 134
Merry (bib0305) 2010; 9
Cardozo, Pagano (bib0410) 2007; 8
Kanie, T.
Jin (bib0120) 2003; 17
Jin (bib0130) 2008; 283
Cheng, Chen (bib0180) 2011; 10
Kanemori (bib0165) 2005; 102
Kim, Diehl (bib0185) 2009; 220
Seki (bib0270) 2008; 181
Yen, Elledge (bib0380) 2008; 322
Aghajan (bib0420) 2010; 28
Freed (bib0310) 1999; 13
Lin (bib0210) 2006; 24
Peschiaroli (bib0280) 2006; 23
Duensing, Duensing (bib0070) 2010; 676
Pagano (bib0190) 1994; 8
Soucy (bib0395) 2009; 458
Mailand (bib0290) 2006; 23
Shiloh (bib0025) 2003; 3
Barbash, Diehl (bib0230) 2008; 7
Jackson, Bartek (bib0005) 2009; 461
Hoare (bib0015) 2010; 53
Ciccia, Elledge (bib0035) 2010; 40
Uchida (bib0160) 2009; 69
Yen (bib0385) 2008; 322
Polo, Jackson (bib0030) 2011; 25
Matsuoka (bib0375) 2007; 316
Frescas, Pagano (bib0110) 2008; 8
Lee (bib0245) 2006; 281
Rogers (bib0340) 2009; 184
Vaites (bib0250) 2011; 31
Schwartz, Ciechanover (bib0080) 1999; 50
Xia (bib0170) 2009; 106
Deshaies, Joazeiro (bib0085) 2009; 78
Isoda (bib0125) 2009; 20
Habedanck (bib0330) 2005; 7
Hoeijmakers (bib0010) 2001; 411
18809569 - Mol Cell Biol. 2008 Dec;28(23):7245-58
20965415 - Mol Cell. 2010 Oct 22;40(2):179-204
17426725 - Nat Rev Mol Cell Biol. 2007 May;8(5):379-93
15498494 - Curr Biol. 2004 Oct 26;14(20):1852-7
14681206 - Genes Dev. 2003 Dec 15;17(24):3062-74
16275645 - J Biol Chem. 2006 Jan 13;281(2):759-68
20708156 - Cancer Cell. 2010 Aug 9;18(2):147-59
17264206 - Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1847-52
19638579 - Cancer Res. 2009 Aug 15;69(16):6438-44
16934469 - Curr Biol. 2006 Oct 10;16(19):1950-5
19432891 - Cancer Sci. 2009 Jul;100(7):1158-65
16885022 - Mol Cell. 2006 Aug 4;23(3):319-29
19360080 - Nature. 2009 Apr 9;458(7239):732-6
20181953 - J Biol Chem. 2010 Apr 30;285(18):13896-906
20581845 - Nat Biotechnol. 2010 Jul;28(7):738-42
10929713 - Cell. 2000 Jul 7;102(1):55-66
20739078 - J Hepatol. 2010 Nov;53(5):950-61
11544175 - Genes Dev. 2001 Sep 1;15(17):2177-96
18047746 - BMC Biochem. 2007;8 Suppl 1:S9
21386656 - Cell Cycle. 2011 Apr 1;10(7):1162-6
7958844 - Genes Dev. 1994 Jul 15;8(14):1627-39
21725316 - Nat Cell Biol. 2011 Aug;13(8):1004-9
12612651 - Nat Rev Cancer. 2003 Mar;3(3):155-68
19679553 - Cancer Res. 2009 Aug 15;69(16):6668-75
15688063 - Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20
21911473 - Mol Cell Biol. 2011 Nov;31(22):4513-23
12417738 - Mol Cell Biol. 2002 Dec;22(23):8375-87
8108113 - Oncogene. 1994 Mar;9(3):707-18
15640846 - Oncogene. 2005 Jan 10;24(2):299-305
17205132 - PLoS One. 2006;1:e128
17525332 - Science. 2007 May 25;316(5828):1160-6
17081987 - Mol Cell. 2006 Nov 3;24(3):355-66
18988847 - Science. 2008 Nov 7;322(5903):918-23
21363960 - Genes Dev. 2011 Mar 1;25(5):409-33
19412162 - Nature. 2009 Jun 4;459(7247):722-5
20581844 - Nat Biotechnol. 2010 Jul;28(7):733-7
21247385 - Curr Cancer Drug Targets. 2011 Mar;11(3):347-56
15520277 - Genes Dev. 2004 Nov 1;18(21):2573-80
18354482 - Nature. 2008 Mar 20;452(7185):365-9
19415697 - J Cell Physiol. 2009 Aug;220(2):292-6
20525923 - Blood. 2010 Sep 2;116(9):1515-23
19171756 - J Cell Biol. 2009 Jan 26;184(2):225-39
20023404 - Cell Cycle. 2010 Jan 15;9(2):279-83
19489725 - Annu Rev Biochem. 2009;78:399-434
19716789 - Mol Cell. 2009 Aug 28;35(4):442-53
14603323 - Nature. 2003 Nov 6;426(6962):87-91
21664912 - FEBS Lett. 2011 Sep 16;585(18):2914-9
18818515 - Cell Cycle. 2008 Oct;7(19):2983-6
20439707 - Proc Natl Acad Sci U S A. 2010 May 18;107(20):9210-5
16244668 - Nat Cell Biol. 2005 Nov;7(11):1140-6
19244340 - Mol Biol Cell. 2009 Apr;20(8):2186-95
15340381 - Nat Rev Mol Cell Biol. 2004 Sep;5(9):739-51
18727509 - Adv Exp Med Biol. 2005;570:393-421
20596027 - Nature. 2010 Jul 1;466(7302):138-42
18500245 - Nat Rev Cancer. 2008 Jun;8(6):438-49
19084407 - Curr Biol. 2009 Jan 13;19(1):43-9
20580718 - FEBS Lett. 2010 Sep 10;584(17):3675-81
19847258 - Nature. 2009 Oct 22;461(7267):1071-8
18662541 - Cell. 2008 Jul 25;134(2):256-67
19196987 - Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2629-34
15845771 - Proc Natl Acad Sci U S A. 2005 May 3;102(18):6279-84
16137618 - Mol Cell. 2005 Sep 2;19(5):607-18
18598945 - Cancer Cell. 2008 Jul 8;14(1):68-78
10485847 - Genes Dev. 1999 Sep 1;13(17):2242-57
20516151 - J Cell Sci. 2010 Jul 1;123(Pt 13):2163-9
16885021 - Mol Cell. 2006 Aug 4;23(3):307-18
20348946 - Oncogene. 2010 Jun 10;29(23):3324-34
12791266 - Dev Cell. 2003 Jun;4(6):799-812
11357144 - Nature. 2001 May 17;411(6835):366-74
19775879 - Curr Opin Cell Biol. 2009 Dec;21(6):816-24
15070733 - Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4419-24
18378770 - J Cell Biol. 2008 Apr 7;181(1):65-78
19734889 - Nat Cell Biol. 2009 Oct;11(10):1247-53
20687471 - Adv Exp Med Biol. 2010;676:93-103
18615013 - Nature. 2008 Sep 4;455(7209):119-23
20090422 - Cell Cycle. 2010 Feb 1;9(3):450-5
21392584 - Semin Cell Dev Biol. 2011 Aug;22(6):595-601
18988848 - Science. 2008 Nov 7;322(5903):923-9
21242966 - Oncogene. 2011 Apr 28;30(17):1995-2002
15242640 - Cell. 2004 Jul 9;118(1):9-17
18354483 - Nature. 2008 Mar 20;452(7185):370-4
18480045 - J Biol Chem. 2008 Jul 11;283(28):19322-8
10073263 - Annu Rev Med. 1999;50:57-74
9759494 - Annu Rev Biochem. 1998;67:425-79
Rogers (10.1016/j.tibs.2011.10.004_bib0340) 2009; 184
Westbrook (10.1016/j.tibs.2011.10.004_bib0365) 2008; 452
Pagano (10.1016/j.tibs.2011.10.004_bib0190) 1994; 8
Matsuoka (10.1016/j.tibs.2011.10.004_bib0375) 2007; 316
Hoare (10.1016/j.tibs.2011.10.004_bib0015) 2010; 53
Ciccia (10.1016/j.tibs.2011.10.004_bib0035) 2010; 40
Jackson (10.1016/j.tibs.2011.10.004_bib0005) 2009; 461
Lee (10.1016/j.tibs.2011.10.004_bib0245) 2006; 281
Lukas (10.1016/j.tibs.2011.10.004_bib0195) 1994; 9
Agami (10.1016/j.tibs.2011.10.004_bib0200) 2000; 102
Barbash (10.1016/j.tibs.2011.10.004_bib0230) 2008; 7
Guardavaccaro (10.1016/j.tibs.2011.10.004_bib0355) 2003; 4
Orlicky (10.1016/j.tibs.2011.10.004_bib0415) 2010; 28
Petroski (10.1016/j.tibs.2011.10.004_bib0090) 2005; 6
Skaar (10.1016/j.tibs.2011.10.004_bib0095) 2009; 21
Bakkenist (10.1016/j.tibs.2011.10.004_bib0040) 2004; 118
Deshaies (10.1016/j.tibs.2011.10.004_bib0085) 2009; 78
Pontano (10.1016/j.tibs.2011.10.004_bib0255) 2008; 28
Merry (10.1016/j.tibs.2011.10.004_bib0305) 2010; 9
Bekker-Jensen (10.1016/j.tibs.2011.10.004_bib0370) 2011; 585
Fang (10.1016/j.tibs.2011.10.004_bib0055) 2011; 22
Vaites (10.1016/j.tibs.2011.10.004_bib0250) 2011; 31
Hoeijmakers (10.1016/j.tibs.2011.10.004_bib0010) 2001; 411
Shiloh (10.1016/j.tibs.2011.10.004_bib0025) 2003; 3
Yen (10.1016/j.tibs.2011.10.004_bib0380) 2008; 322
Lingle (10.1016/j.tibs.2011.10.004_bib0065) 2005; 570
Soucy (10.1016/j.tibs.2011.10.004_bib0395) 2009; 458
Polo (10.1016/j.tibs.2011.10.004_bib0030) 2011; 25
Tanaka (10.1016/j.tibs.2011.10.004_bib0060) 2009; 100
Barbash (10.1016/j.tibs.2011.10.004_bib0205) 2008; 14
Busino (10.1016/j.tibs.2011.10.004_bib0115) 2003; 426
Jin (10.1016/j.tibs.2011.10.004_bib0130) 2008; 283
Zhang (10.1016/j.tibs.2011.10.004_bib0295) 2005; 19
Kanemori (10.1016/j.tibs.2011.10.004_bib0165) 2005; 102
D’Angiolella (10.1016/j.tibs.2011.10.004_bib0320) 2010; 466
Puklowski (10.1016/j.tibs.2011.10.004_bib0325) 2011; 13
Pawar (10.1016/j.tibs.2011.10.004_bib0220) 2010; 107
Milhollen (10.1016/j.tibs.2011.10.004_bib0405) 2010; 116
Santra (10.1016/j.tibs.2011.10.004_bib0225) 2009; 459
Musacchio (10.1016/j.tibs.2011.10.004_bib0050) 2007; 8
Korzeniewski (10.1016/j.tibs.2011.10.004_bib0335) 2009; 69
Lin (10.1016/j.tibs.2011.10.004_bib0210) 2006; 24
Okabe (10.1016/j.tibs.2011.10.004_bib0215) 2006; 1
Sorensen (10.1016/j.tibs.2011.10.004_bib0155) 2010; 9
Aghajan (10.1016/j.tibs.2011.10.004_bib0420) 2010; 28
Honaker (10.1016/j.tibs.2011.10.004_bib0135) 2010; 29
Xia (10.1016/j.tibs.2011.10.004_bib0170) 2009; 106
Li (10.1016/j.tibs.2011.10.004_bib0240) 2010; 285
Piva (10.1016/j.tibs.2011.10.004_bib0315) 2002; 22
Cheng (10.1016/j.tibs.2011.10.004_bib0180) 2011; 10
Mamely (10.1016/j.tibs.2011.10.004_bib0285) 2006; 16
Melixetian (10.1016/j.tibs.2011.10.004_bib0150) 2009; 11
Myer (10.1016/j.tibs.2011.10.004_bib0140) 2005; 24
Yen (10.1016/j.tibs.2011.10.004_bib0385) 2008; 322
Kim (10.1016/j.tibs.2011.10.004_bib0185) 2009; 220
Jin (10.1016/j.tibs.2011.10.004_bib0105) 2004; 18
Derheimer (10.1016/j.tibs.2011.10.004_bib0045) 2010; 584
Schwartz (10.1016/j.tibs.2011.10.004_bib0080) 1999; 50
Zhang (10.1016/j.tibs.2011.10.004_bib0300) 2009; 35
Duensing (10.1016/j.tibs.2011.10.004_bib0070) 2010; 676
Frescas (10.1016/j.tibs.2011.10.004_bib0110) 2008; 8
Isoda (10.1016/j.tibs.2011.10.004_bib0125) 2009; 20
Macurek (10.1016/j.tibs.2011.10.004_bib0260) 2008; 455
Abraham (10.1016/j.tibs.2011.10.004_bib0020) 2001; 15
Freed (10.1016/j.tibs.2011.10.004_bib0310) 1999; 13
Seki (10.1016/j.tibs.2011.10.004_bib0270) 2008; 181
10.1016/j.tibs.2011.10.004_bib0425
Guderian (10.1016/j.tibs.2011.10.004_bib0350) 2010; 123
Peschiaroli (10.1016/j.tibs.2011.10.004_bib0280) 2006; 23
Jin (10.1016/j.tibs.2011.10.004_bib0120) 2003; 17
Inuzuka (10.1016/j.tibs.2011.10.004_bib0175) 2010; 18
Cardozo (10.1016/j.tibs.2011.10.004_bib0410) 2007; 8
Watanabe (10.1016/j.tibs.2011.10.004_bib0275) 2004; 101
Guardavaccaro (10.1016/j.tibs.2011.10.004_bib0360) 2008; 452
Bassermann (10.1016/j.tibs.2011.10.004_bib0265) 2008; 134
Cardozo (10.1016/j.tibs.2011.10.004_bib0100) 2004; 5
Hershko (10.1016/j.tibs.2011.10.004_bib0075) 1998; 67
Habedanck (10.1016/j.tibs.2011.10.004_bib0330) 2005; 7
Cunha-Ferreira (10.1016/j.tibs.2011.10.004_bib0345) 2009; 19
Uchida (10.1016/j.tibs.2011.10.004_bib0160) 2009; 69
Zimmerman (10.1016/j.tibs.2011.10.004_bib0145) 2007; 104
Welcker (10.1016/j.tibs.2011.10.004_bib0390) 2004; 14
Barbash (10.1016/j.tibs.2011.10.004_bib0235) 2011; 30
Mailand (10.1016/j.tibs.2011.10.004_bib0290) 2006; 23
Jia (10.1016/j.tibs.2011.10.004_bib0400) 2011; 11
References_xml – volume: 53
  start-page: 950
  year: 2010
  end-page: 961
  ident: bib0015
  article-title: Ageing, telomeres, senescence, and liver injury
  publication-title: J. Hepatol.
  contributor:
    fullname: Hoare
– volume: 100
  start-page: 1158
  year: 2009
  end-page: 1165
  ident: bib0060
  article-title: Chromosome segregation machinery and cancer
  publication-title: Cancer Sci.
  contributor:
    fullname: Hirota
– volume: 102
  start-page: 55
  year: 2000
  end-page: 66
  ident: bib0200
  article-title: Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
  publication-title: Cell
  contributor:
    fullname: Bernards
– volume: 40
  start-page: 179
  year: 2010
  end-page: 204
  ident: bib0035
  article-title: The DNA damage response: making it safe to play with knives
  publication-title: Mol. Cell
  contributor:
    fullname: Elledge
– volume: 459
  start-page: 722
  year: 2009
  end-page: 725
  ident: bib0225
  article-title: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
  publication-title: Nature
  contributor:
    fullname: Santra
– volume: 585
  start-page: 2914
  year: 2011
  end-page: 2919
  ident: bib0370
  article-title: The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks
  publication-title: FEBS Lett.
  contributor:
    fullname: Mailand
– volume: 283
  start-page: 19322
  year: 2008
  end-page: 19328
  ident: bib0130
  article-title: Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Jin
– volume: 29
  start-page: 3324
  year: 2010
  end-page: 3334
  ident: bib0135
  article-title: Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction
  publication-title: Oncogene
  contributor:
    fullname: Piwnica-Worms
– volume: 10
  start-page: 1162
  year: 2011
  end-page: 1166
  ident: bib0180
  article-title: The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation
  publication-title: Cell Cycle
  contributor:
    fullname: Chen
– volume: 134
  start-page: 256
  year: 2008
  end-page: 267
  ident: bib0265
  article-title: The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
  publication-title: Cell
  contributor:
    fullname: Bassermann
– volume: 23
  start-page: 307
  year: 2006
  end-page: 318
  ident: bib0290
  article-title: Destruction of Claspin by SCF
  publication-title: Mol. Cell
  contributor:
    fullname: Mailand
– volume: 69
  start-page: 6668
  year: 2009
  end-page: 6675
  ident: bib0335
  article-title: Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels
  publication-title: Cancer Res.
  contributor:
    fullname: Korzeniewski
– volume: 123
  start-page: 2163
  year: 2010
  end-page: 2169
  ident: bib0350
  article-title: Plk4
  publication-title: J. Cell Sci.
  contributor:
    fullname: Guderian
– volume: 25
  start-page: 409
  year: 2011
  end-page: 433
  ident: bib0030
  article-title: Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
  publication-title: Genes Dev.
  contributor:
    fullname: Jackson
– volume: 19
  start-page: 43
  year: 2009
  end-page: 49
  ident: bib0345
  article-title: The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4
  publication-title: Curr. Biol.
  contributor:
    fullname: Cunha-Ferreira
– volume: 7
  start-page: 2983
  year: 2008
  end-page: 2986
  ident: bib0230
  article-title: SCF
  publication-title: Cell Cycle
  contributor:
    fullname: Diehl
– volume: 184
  start-page: 225
  year: 2009
  end-page: 239
  ident: bib0340
  article-title: The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication
  publication-title: J. Cell Biol.
  contributor:
    fullname: Rogers
– volume: 116
  start-page: 1515
  year: 2010
  end-page: 1523
  ident: bib0405
  article-title: MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB-dependent lymphoma
  publication-title: Blood
  contributor:
    fullname: Milhollen
– volume: 28
  start-page: 738
  year: 2010
  end-page: 742
  ident: bib0420
  article-title: Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Aghajan
– volume: 8
  start-page: 438
  year: 2008
  end-page: 449
  ident: bib0110
  article-title: Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
  publication-title: Nat. Rev. Cancer
  contributor:
    fullname: Pagano
– volume: 8
  start-page: 1627
  year: 1994
  end-page: 1639
  ident: bib0190
  article-title: Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
  publication-title: Genes Dev.
  contributor:
    fullname: Pagano
– volume: 9
  start-page: 279
  year: 2010
  end-page: 283
  ident: bib0305
  article-title: Targeting the checkpoint kinase Chk1 in cancer therapy
  publication-title: Cell Cycle
  contributor:
    fullname: Merry
– volume: 21
  start-page: 816
  year: 2009
  end-page: 824
  ident: bib0095
  article-title: Control of cell growth by the SCF and APC/C ubiquitin ligases
  publication-title: Curr. Opin. Cell Biol.
  contributor:
    fullname: Pagano
– volume: 8
  start-page: 379
  year: 2007
  end-page: 393
  ident: bib0050
  article-title: The spindle-assembly checkpoint in space and time
  publication-title: Nat. Rev. Mol. Cell Biol.
  contributor:
    fullname: Salmon
– volume: 426
  start-page: 87
  year: 2003
  end-page: 91
  ident: bib0115
  article-title: Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
  publication-title: Nature
  contributor:
    fullname: Busino
– volume: 466
  start-page: 138
  year: 2010
  end-page: 142
  ident: bib0320
  article-title: SCF
  publication-title: Nature
  contributor:
    fullname: D’Angiolella
– volume: 22
  start-page: 8375
  year: 2002
  end-page: 8387
  ident: bib0315
  article-title: In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Piva
– volume: 7
  start-page: 1140
  year: 2005
  end-page: 1146
  ident: bib0330
  article-title: The Polo kinase Plk4 functions in centriole duplication
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Habedanck
– volume: 676
  start-page: 93
  year: 2010
  end-page: 103
  ident: bib0070
  article-title: Centrosomes, polyploidy and cancer
  publication-title: Adv. Exp. Med. Biol.
  contributor:
    fullname: Duensing
– volume: 452
  start-page: 370
  year: 2008
  end-page: 374
  ident: bib0365
  article-title: SCF
  publication-title: Nature
  contributor:
    fullname: Westbrook
– volume: 5
  start-page: 739
  year: 2004
  end-page: 751
  ident: bib0100
  article-title: The SCF ubiquitin ligase: insights into a molecular machine
  publication-title: Nat. Rev. Mol. Cell Biol.
  contributor:
    fullname: Pagano
– volume: 322
  start-page: 918
  year: 2008
  end-page: 923
  ident: bib0385
  article-title: Global protein stability profiling in mammalian cells
  publication-title: Science
  contributor:
    fullname: Yen
– volume: 107
  start-page: 9210
  year: 2010
  end-page: 9215
  ident: bib0220
  article-title: C/EBPδ targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  contributor:
    fullname: Pawar
– volume: 9
  start-page: 450
  year: 2010
  end-page: 455
  ident: bib0155
  article-title: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling
  publication-title: Cell Cycle
  contributor:
    fullname: Sorensen
– volume: 31
  start-page: 4513
  year: 2011
  end-page: 4523
  ident: bib0250
  article-title: The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Vaites
– volume: 452
  start-page: 365
  year: 2008
  end-page: 369
  ident: bib0360
  article-title: Control of chromosome stability by the β-TrCP-REST-Mad2 axis
  publication-title: Nature
  contributor:
    fullname: Guardavaccaro
– volume: 22
  start-page: 595
  year: 2011
  end-page: 601
  ident: bib0055
  article-title: Aneuploidy and tumorigenesis
  publication-title: Semin. Cell Dev. Biol.
  contributor:
    fullname: Zhang
– volume: 16
  start-page: 1950
  year: 2006
  end-page: 1955
  ident: bib0285
  article-title: Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
  publication-title: Curr. Biol.
  contributor:
    fullname: Mamely
– volume: 220
  start-page: 292
  year: 2009
  end-page: 296
  ident: bib0185
  article-title: Nuclear cyclin D1: an oncogenic driver in human cancer
  publication-title: J. Cell. Physiol.
  contributor:
    fullname: Diehl
– volume: 570
  start-page: 393
  year: 2005
  end-page: 421
  ident: bib0065
  article-title: Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer
  publication-title: Adv. Exp. Med. Biol.
  contributor:
    fullname: Lingle
– volume: 19
  start-page: 607
  year: 2005
  end-page: 618
  ident: bib0295
  article-title: Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway
  publication-title: Mol. Cell
  contributor:
    fullname: Zhang
– volume: 104
  start-page: 1847
  year: 2007
  end-page: 1852
  ident: bib0145
  article-title: Polo-like kinase 3 is required for entry into S phase
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  contributor:
    fullname: Erikson
– volume: 101
  start-page: 4419
  year: 2004
  end-page: 4424
  ident: bib0275
  article-title: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  contributor:
    fullname: Watanabe
– volume: 13
  start-page: 1004
  year: 2011
  end-page: 1009
  ident: bib0325
  article-title: The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Puklowski
– volume: 11
  start-page: 347
  year: 2011
  end-page: 356
  ident: bib0400
  article-title: SCF E3 ubiquitin ligases as anticancer targets
  publication-title: Curr. Cancer Drug Targets
  contributor:
    fullname: Sun
– volume: 9
  start-page: 707
  year: 1994
  end-page: 718
  ident: bib0195
  article-title: Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines
  publication-title: Oncogene
  contributor:
    fullname: Lukas
– volume: 18
  start-page: 147
  year: 2010
  end-page: 159
  ident: bib0175
  article-title: Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF
  publication-title: Cancer Cell
  contributor:
    fullname: Inuzuka
– volume: 458
  start-page: 732
  year: 2009
  end-page: 736
  ident: bib0395
  article-title: An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
  publication-title: Nature
  contributor:
    fullname: Soucy
– volume: 24
  start-page: 299
  year: 2005
  end-page: 305
  ident: bib0140
  article-title: The Plk3-Cdc25 circuit
  publication-title: Oncogene
  contributor:
    fullname: Myer
– volume: 67
  start-page: 425
  year: 1998
  end-page: 479
  ident: bib0075
  article-title: The ubiquitin system
  publication-title: Annu. Rev. Biochem.
  contributor:
    fullname: Ciechanover
– volume: 17
  start-page: 3062
  year: 2003
  end-page: 3074
  ident: bib0120
  article-title: SCF
  publication-title: Genes Dev.
  contributor:
    fullname: Jin
– volume: 28
  start-page: 733
  year: 2010
  end-page: 737
  ident: bib0415
  article-title: An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: Orlicky
– volume: 8
  start-page: S9
  year: 2007
  ident: bib0410
  article-title: Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
  publication-title: BMC Biochem.
  contributor:
    fullname: Pagano
– volume: 20
  start-page: 2186
  year: 2009
  end-page: 2195
  ident: bib0125
  article-title: The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF
  publication-title: Mol. Biol. Cell
  contributor:
    fullname: Isoda
– volume: 15
  start-page: 2177
  year: 2001
  end-page: 2196
  ident: bib0020
  article-title: Cell cycle checkpoint signaling through the ATM and ATR kinases
  publication-title: Genes Dev.
  contributor:
    fullname: Abraham
– volume: 50
  start-page: 57
  year: 1999
  end-page: 74
  ident: bib0080
  article-title: The ubiquitin-proteasome pathway and pathogenesis of human diseases
  publication-title: Annu. Rev. Med.
  contributor:
    fullname: Ciechanover
– volume: 118
  start-page: 9
  year: 2004
  end-page: 17
  ident: bib0040
  article-title: Initiating cellular stress responses
  publication-title: Cell
  contributor:
    fullname: Kastan
– volume: 411
  start-page: 366
  year: 2001
  end-page: 374
  ident: bib0010
  article-title: Genome maintenance mechanisms for preventing cancer
  publication-title: Nature
  contributor:
    fullname: Hoeijmakers
– volume: 102
  start-page: 6279
  year: 2005
  end-page: 6284
  ident: bib0165
  article-title: β-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  contributor:
    fullname: Kanemori
– volume: 285
  start-page: 13896
  year: 2010
  end-page: 13906
  ident: bib0240
  article-title: Structural basis of dimerization-dependent ubiquitination by the SCF
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Hao
– volume: 6
  start-page: 9
  year: 2005
  end-page: 20
  ident: bib0090
  article-title: Function and regulation of cullin-RING ubiquitin ligases
  publication-title: Nat. Rev. Mol. Cell Biol.
  contributor:
    fullname: Deshaies
– volume: 1
  start-page: e128
  year: 2006
  ident: bib0215
  article-title: A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
  publication-title: PLoS ONE
  contributor:
    fullname: Okabe
– volume: 24
  start-page: 355
  year: 2006
  end-page: 366
  ident: bib0210
  article-title: Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF
  publication-title: Mol. Cell
  contributor:
    fullname: Lin
– volume: 11
  start-page: 1247
  year: 2009
  end-page: 1253
  ident: bib0150
  article-title: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Melixetian
– volume: 584
  start-page: 3675
  year: 2010
  end-page: 3681
  ident: bib0045
  article-title: Multiple roles of ATM in monitoring and maintaining DNA integrity
  publication-title: FEBS Lett.
  contributor:
    fullname: Kastan
– volume: 455
  start-page: 119
  year: 2008
  end-page: 123
  ident: bib0260
  article-title: Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
  publication-title: Nature
  contributor:
    fullname: Macurek
– volume: 461
  start-page: 1071
  year: 2009
  end-page: 1078
  ident: bib0005
  article-title: The DNA-damage response in human biology and disease
  publication-title: Nature
  contributor:
    fullname: Bartek
– volume: 281
  start-page: 759
  year: 2006
  end-page: 768
  ident: bib0245
  article-title: The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Lee
– volume: 28
  start-page: 7245
  year: 2008
  end-page: 7258
  ident: bib0255
  article-title: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Pontano
– volume: 4
  start-page: 799
  year: 2003
  end-page: 812
  ident: bib0355
  article-title: Control of meiotic and mitotic progression by the F box protein β-Trcp1
  publication-title: Dev. Cell
  contributor:
    fullname: Guardavaccaro
– volume: 18
  start-page: 2573
  year: 2004
  end-page: 2580
  ident: bib0105
  article-title: Systematic analysis and nomenclature of mammalian F-box proteins
  publication-title: Genes Dev.
  contributor:
    fullname: Jin
– volume: 78
  start-page: 399
  year: 2009
  end-page: 434
  ident: bib0085
  article-title: RING domain E3 ubiquitin ligases
  publication-title: Annu. Rev. Biochem.
  contributor:
    fullname: Joazeiro
– volume: 69
  start-page: 6438
  year: 2009
  end-page: 6444
  ident: bib0160
  article-title: Stress-activated mitogen-activated protein kinases c-Jun NH
  publication-title: Cancer Res.
  contributor:
    fullname: Uchida
– volume: 23
  start-page: 319
  year: 2006
  end-page: 329
  ident: bib0280
  article-title: SCF
  publication-title: Mol. Cell
  contributor:
    fullname: Peschiaroli
– volume: 14
  start-page: 1852
  year: 2004
  end-page: 1857
  ident: bib0390
  article-title: A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
  publication-title: Curr. Biol.
  contributor:
    fullname: Welcker
– volume: 3
  start-page: 155
  year: 2003
  end-page: 168
  ident: bib0025
  article-title: ATM and related protein kinases: safeguarding genome integrity
  publication-title: Nat. Rev. Cancer
  contributor:
    fullname: Shiloh
– volume: 14
  start-page: 68
  year: 2008
  end-page: 78
  ident: bib0205
  article-title: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer
  publication-title: Cancer Cell
  contributor:
    fullname: Barbash
– volume: 316
  start-page: 1160
  year: 2007
  end-page: 1166
  ident: bib0375
  article-title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
  publication-title: Science
  contributor:
    fullname: Matsuoka
– volume: 30
  start-page: 1995
  year: 2011
  end-page: 2002
  ident: bib0235
  article-title: Phosphorylation-dependent regulation of SCF
  publication-title: Oncogene
  contributor:
    fullname: Barbash
– volume: 13
  start-page: 2242
  year: 1999
  end-page: 2257
  ident: bib0310
  article-title: Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
  publication-title: Genes Dev.
  contributor:
    fullname: Freed
– volume: 106
  start-page: 2629
  year: 2009
  end-page: 2634
  ident: bib0170
  article-title: Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  contributor:
    fullname: Xia
– volume: 181
  start-page: 65
  year: 2008
  end-page: 78
  ident: bib0270
  article-title: Plk1- and β-TrCP-dependent degradation of Bora controls mitotic progression
  publication-title: J. Cell Biol.
  contributor:
    fullname: Seki
– volume: 35
  start-page: 442
  year: 2009
  end-page: 453
  ident: bib0300
  article-title: The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
  publication-title: Mol. Cell
  contributor:
    fullname: Zhang
– volume: 322
  start-page: 923
  year: 2008
  end-page: 929
  ident: bib0380
  article-title: Identification of SCF ubiquitin ligase substrates by global protein stability profiling
  publication-title: Science
  contributor:
    fullname: Elledge
– volume: 426
  start-page: 87
  year: 2003
  ident: 10.1016/j.tibs.2011.10.004_bib0115
  article-title: Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
  publication-title: Nature
  doi: 10.1038/nature02082
  contributor:
    fullname: Busino
– volume: 1
  start-page: e128
  year: 2006
  ident: 10.1016/j.tibs.2011.10.004_bib0215
  article-title: A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000128
  contributor:
    fullname: Okabe
– volume: 322
  start-page: 923
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0380
  article-title: Identification of SCF ubiquitin ligase substrates by global protein stability profiling
  publication-title: Science
  doi: 10.1126/science.1160462
  contributor:
    fullname: Yen
– volume: 28
  start-page: 733
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0415
  article-title: An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1646
  contributor:
    fullname: Orlicky
– volume: 281
  start-page: 759
  year: 2006
  ident: 10.1016/j.tibs.2011.10.004_bib0245
  article-title: The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M509855200
  contributor:
    fullname: Lee
– volume: 585
  start-page: 2914
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0370
  article-title: The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2011.05.056
  contributor:
    fullname: Bekker-Jensen
– volume: 23
  start-page: 319
  year: 2006
  ident: 10.1016/j.tibs.2011.10.004_bib0280
  article-title: SCFβ-TrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2006.06.013
  contributor:
    fullname: Peschiaroli
– ident: 10.1016/j.tibs.2011.10.004_bib0425
  doi: 10.1128/MCB.06570-11
– volume: 220
  start-page: 292
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0185
  article-title: Nuclear cyclin D1: an oncogenic driver in human cancer
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.21791
  contributor:
    fullname: Kim
– volume: 8
  start-page: S9
  issue: Suppl. 1
  year: 2007
  ident: 10.1016/j.tibs.2011.10.004_bib0410
  article-title: Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
  publication-title: BMC Biochem.
  doi: 10.1186/1471-2091-8-S1-S9
  contributor:
    fullname: Cardozo
– volume: 11
  start-page: 347
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0400
  article-title: SCF E3 ubiquitin ligases as anticancer targets
  publication-title: Curr. Cancer Drug Targets
  doi: 10.2174/156800911794519734
  contributor:
    fullname: Jia
– volume: 285
  start-page: 13896
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0240
  article-title: Structural basis of dimerization-dependent ubiquitination by the SCFFbx4 ubiquitin ligase
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.111518
  contributor:
    fullname: Li
– volume: 9
  start-page: 450
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0155
  article-title: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.3.10513
  contributor:
    fullname: Sorensen
– volume: 40
  start-page: 179
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0035
  article-title: The DNA damage response: making it safe to play with knives
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.09.019
  contributor:
    fullname: Ciccia
– volume: 102
  start-page: 6279
  year: 2005
  ident: 10.1016/j.tibs.2011.10.004_bib0165
  article-title: β-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0501873102
  contributor:
    fullname: Kanemori
– volume: 411
  start-page: 366
  year: 2001
  ident: 10.1016/j.tibs.2011.10.004_bib0010
  article-title: Genome maintenance mechanisms for preventing cancer
  publication-title: Nature
  doi: 10.1038/35077232
  contributor:
    fullname: Hoeijmakers
– volume: 102
  start-page: 55
  year: 2000
  ident: 10.1016/j.tibs.2011.10.004_bib0200
  article-title: Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)00010-6
  contributor:
    fullname: Agami
– volume: 22
  start-page: 595
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0055
  article-title: Aneuploidy and tumorigenesis
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2011.03.002
  contributor:
    fullname: Fang
– volume: 584
  start-page: 3675
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0045
  article-title: Multiple roles of ATM in monitoring and maintaining DNA integrity
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2010.05.031
  contributor:
    fullname: Derheimer
– volume: 4
  start-page: 799
  year: 2003
  ident: 10.1016/j.tibs.2011.10.004_bib0355
  article-title: Control of meiotic and mitotic progression by the F box protein β-Trcp1 in vivo
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(03)00154-0
  contributor:
    fullname: Guardavaccaro
– volume: 107
  start-page: 9210
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0220
  article-title: C/EBPδ targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0913813107
  contributor:
    fullname: Pawar
– volume: 35
  start-page: 442
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0300
  article-title: The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.06.030
  contributor:
    fullname: Zhang
– volume: 14
  start-page: 68
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0205
  article-title: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2008.05.017
  contributor:
    fullname: Barbash
– volume: 570
  start-page: 393
  year: 2005
  ident: 10.1016/j.tibs.2011.10.004_bib0065
  article-title: Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/1-4020-3764-3_14
  contributor:
    fullname: Lingle
– volume: 69
  start-page: 6668
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0335
  article-title: Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-1284
  contributor:
    fullname: Korzeniewski
– volume: 67
  start-page: 425
  year: 1998
  ident: 10.1016/j.tibs.2011.10.004_bib0075
  article-title: The ubiquitin system
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.67.1.425
  contributor:
    fullname: Hershko
– volume: 18
  start-page: 147
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0175
  article-title: Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2010.06.015
  contributor:
    fullname: Inuzuka
– volume: 30
  start-page: 1995
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0235
  article-title: Phosphorylation-dependent regulation of SCFFbx4 dimerization and activity involves a novel component, 14-3-3ɛ
  publication-title: Oncogene
  doi: 10.1038/onc.2010.584
  contributor:
    fullname: Barbash
– volume: 123
  start-page: 2163
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0350
  article-title: Plk4 trans-autophosphorylation regulates centriole number by controlling βTrCP-mediated degradation
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.068502
  contributor:
    fullname: Guderian
– volume: 31
  start-page: 4513
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0250
  article-title: The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.05733-11
  contributor:
    fullname: Vaites
– volume: 5
  start-page: 739
  year: 2004
  ident: 10.1016/j.tibs.2011.10.004_bib0100
  article-title: The SCF ubiquitin ligase: insights into a molecular machine
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1471
  contributor:
    fullname: Cardozo
– volume: 106
  start-page: 2629
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0170
  article-title: Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0812256106
  contributor:
    fullname: Xia
– volume: 23
  start-page: 307
  year: 2006
  ident: 10.1016/j.tibs.2011.10.004_bib0290
  article-title: Destruction of Claspin by SCFβ-TrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2006.06.016
  contributor:
    fullname: Mailand
– volume: 22
  start-page: 8375
  year: 2002
  ident: 10.1016/j.tibs.2011.10.004_bib0315
  article-title: In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.22.23.8375-8387.2002
  contributor:
    fullname: Piva
– volume: 461
  start-page: 1071
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0005
  article-title: The DNA-damage response in human biology and disease
  publication-title: Nature
  doi: 10.1038/nature08467
  contributor:
    fullname: Jackson
– volume: 14
  start-page: 1852
  year: 2004
  ident: 10.1016/j.tibs.2011.10.004_bib0390
  article-title: A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2004.09.083
  contributor:
    fullname: Welcker
– volume: 181
  start-page: 65
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0270
  article-title: Plk1- and β-TrCP-dependent degradation of Bora controls mitotic progression
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200712027
  contributor:
    fullname: Seki
– volume: 455
  start-page: 119
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0260
  article-title: Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
  publication-title: Nature
  doi: 10.1038/nature07185
  contributor:
    fullname: Macurek
– volume: 134
  start-page: 256
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0265
  article-title: The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
  publication-title: Cell
  doi: 10.1016/j.cell.2008.05.043
  contributor:
    fullname: Bassermann
– volume: 19
  start-page: 607
  year: 2005
  ident: 10.1016/j.tibs.2011.10.004_bib0295
  article-title: Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2005.07.019
  contributor:
    fullname: Zhang
– volume: 53
  start-page: 950
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0015
  article-title: Ageing, telomeres, senescence, and liver injury
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.06.009
  contributor:
    fullname: Hoare
– volume: 118
  start-page: 9
  year: 2004
  ident: 10.1016/j.tibs.2011.10.004_bib0040
  article-title: Initiating cellular stress responses
  publication-title: Cell
  doi: 10.1016/j.cell.2004.06.023
  contributor:
    fullname: Bakkenist
– volume: 3
  start-page: 155
  year: 2003
  ident: 10.1016/j.tibs.2011.10.004_bib0025
  article-title: ATM and related protein kinases: safeguarding genome integrity
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1011
  contributor:
    fullname: Shiloh
– volume: 9
  start-page: 707
  year: 1994
  ident: 10.1016/j.tibs.2011.10.004_bib0195
  article-title: Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines
  publication-title: Oncogene
  contributor:
    fullname: Lukas
– volume: 184
  start-page: 225
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0340
  article-title: The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200808049
  contributor:
    fullname: Rogers
– volume: 459
  start-page: 722
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0225
  article-title: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage
  publication-title: Nature
  doi: 10.1038/nature08011
  contributor:
    fullname: Santra
– volume: 15
  start-page: 2177
  year: 2001
  ident: 10.1016/j.tibs.2011.10.004_bib0020
  article-title: Cell cycle checkpoint signaling through the ATM and ATR kinases
  publication-title: Genes Dev.
  doi: 10.1101/gad.914401
  contributor:
    fullname: Abraham
– volume: 8
  start-page: 379
  year: 2007
  ident: 10.1016/j.tibs.2011.10.004_bib0050
  article-title: The spindle-assembly checkpoint in space and time
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2163
  contributor:
    fullname: Musacchio
– volume: 101
  start-page: 4419
  year: 2004
  ident: 10.1016/j.tibs.2011.10.004_bib0275
  article-title: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0307700101
  contributor:
    fullname: Watanabe
– volume: 13
  start-page: 1004
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0325
  article-title: The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2282
  contributor:
    fullname: Puklowski
– volume: 18
  start-page: 2573
  year: 2004
  ident: 10.1016/j.tibs.2011.10.004_bib0105
  article-title: Systematic analysis and nomenclature of mammalian F-box proteins
  publication-title: Genes Dev.
  doi: 10.1101/gad.1255304
  contributor:
    fullname: Jin
– volume: 8
  start-page: 438
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0110
  article-title: Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2396
  contributor:
    fullname: Frescas
– volume: 9
  start-page: 279
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0305
  article-title: Targeting the checkpoint kinase Chk1 in cancer therapy
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.2.10445
  contributor:
    fullname: Merry
– volume: 283
  start-page: 19322
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0130
  article-title: Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M802474200
  contributor:
    fullname: Jin
– volume: 13
  start-page: 2242
  year: 1999
  ident: 10.1016/j.tibs.2011.10.004_bib0310
  article-title: Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.17.2242
  contributor:
    fullname: Freed
– volume: 458
  start-page: 732
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0395
  article-title: An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
  publication-title: Nature
  doi: 10.1038/nature07884
  contributor:
    fullname: Soucy
– volume: 25
  start-page: 409
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0030
  article-title: Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
  publication-title: Genes Dev.
  doi: 10.1101/gad.2021311
  contributor:
    fullname: Polo
– volume: 19
  start-page: 43
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0345
  article-title: The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2008.11.037
  contributor:
    fullname: Cunha-Ferreira
– volume: 21
  start-page: 816
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0095
  article-title: Control of cell growth by the SCF and APC/C ubiquitin ligases
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2009.08.004
  contributor:
    fullname: Skaar
– volume: 69
  start-page: 6438
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0160
  article-title: Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-0869
  contributor:
    fullname: Uchida
– volume: 8
  start-page: 1627
  year: 1994
  ident: 10.1016/j.tibs.2011.10.004_bib0190
  article-title: Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
  publication-title: Genes Dev.
  doi: 10.1101/gad.8.14.1627
  contributor:
    fullname: Pagano
– volume: 452
  start-page: 370
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0365
  article-title: SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation
  publication-title: Nature
  doi: 10.1038/nature06780
  contributor:
    fullname: Westbrook
– volume: 116
  start-page: 1515
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0405
  article-title: MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB-dependent lymphoma
  publication-title: Blood
  doi: 10.1182/blood-2010-03-272567
  contributor:
    fullname: Milhollen
– volume: 29
  start-page: 3324
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0135
  article-title: Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction
  publication-title: Oncogene
  doi: 10.1038/onc.2010.96
  contributor:
    fullname: Honaker
– volume: 7
  start-page: 1140
  year: 2005
  ident: 10.1016/j.tibs.2011.10.004_bib0330
  article-title: The Polo kinase Plk4 functions in centriole duplication
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1320
  contributor:
    fullname: Habedanck
– volume: 466
  start-page: 138
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0320
  article-title: SCFCyclin F controls centrosome homeostasis and mitotic fidelity through CP110 degradation
  publication-title: Nature
  doi: 10.1038/nature09140
  contributor:
    fullname: D’Angiolella
– volume: 6
  start-page: 9
  year: 2005
  ident: 10.1016/j.tibs.2011.10.004_bib0090
  article-title: Function and regulation of cullin-RING ubiquitin ligases
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1547
  contributor:
    fullname: Petroski
– volume: 104
  start-page: 1847
  year: 2007
  ident: 10.1016/j.tibs.2011.10.004_bib0145
  article-title: Polo-like kinase 3 is required for entry into S phase
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.0610856104
  contributor:
    fullname: Zimmerman
– volume: 24
  start-page: 355
  year: 2006
  ident: 10.1016/j.tibs.2011.10.004_bib0210
  article-title: Phosphorylation-dependent ubiquitination of cyclin D1 by the SCFFBX4-αB crystallin complex
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2006.09.007
  contributor:
    fullname: Lin
– volume: 24
  start-page: 299
  year: 2005
  ident: 10.1016/j.tibs.2011.10.004_bib0140
  article-title: The Plk3-Cdc25 circuit
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1208278
  contributor:
    fullname: Myer
– volume: 322
  start-page: 918
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0385
  article-title: Global protein stability profiling in mammalian cells
  publication-title: Science
  doi: 10.1126/science.1160489
  contributor:
    fullname: Yen
– volume: 16
  start-page: 1950
  year: 2006
  ident: 10.1016/j.tibs.2011.10.004_bib0285
  article-title: Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2006.08.026
  contributor:
    fullname: Mamely
– volume: 100
  start-page: 1158
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0060
  article-title: Chromosome segregation machinery and cancer
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2009.01178.x
  contributor:
    fullname: Tanaka
– volume: 316
  start-page: 1160
  year: 2007
  ident: 10.1016/j.tibs.2011.10.004_bib0375
  article-title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
  publication-title: Science
  doi: 10.1126/science.1140321
  contributor:
    fullname: Matsuoka
– volume: 676
  start-page: 93
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0070
  article-title: Centrosomes, polyploidy and cancer
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4419-6199-0_6
  contributor:
    fullname: Duensing
– volume: 452
  start-page: 365
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0360
  article-title: Control of chromosome stability by the β-TrCP-REST-Mad2 axis
  publication-title: Nature
  doi: 10.1038/nature06641
  contributor:
    fullname: Guardavaccaro
– volume: 20
  start-page: 2186
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0125
  article-title: The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCFβ-TRCP -dependent degradation for cell cycle arrest
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e09-01-0008
  contributor:
    fullname: Isoda
– volume: 17
  start-page: 3062
  year: 2003
  ident: 10.1016/j.tibs.2011.10.004_bib0120
  article-title: SCFβ-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase
  publication-title: Genes Dev.
  doi: 10.1101/gad.1157503
  contributor:
    fullname: Jin
– volume: 10
  start-page: 1162
  year: 2011
  ident: 10.1016/j.tibs.2011.10.004_bib0180
  article-title: The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation
  publication-title: Cell Cycle
  doi: 10.4161/cc.10.7.15249
  contributor:
    fullname: Cheng
– volume: 28
  start-page: 7245
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0255
  article-title: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.01085-08
  contributor:
    fullname: Pontano
– volume: 28
  start-page: 738
  year: 2010
  ident: 10.1016/j.tibs.2011.10.004_bib0420
  article-title: Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1645
  contributor:
    fullname: Aghajan
– volume: 50
  start-page: 57
  year: 1999
  ident: 10.1016/j.tibs.2011.10.004_bib0080
  article-title: The ubiquitin-proteasome pathway and pathogenesis of human diseases
  publication-title: Annu. Rev. Med.
  doi: 10.1146/annurev.med.50.1.57
  contributor:
    fullname: Schwartz
– volume: 11
  start-page: 1247
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0150
  article-title: NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1969
  contributor:
    fullname: Melixetian
– volume: 78
  start-page: 399
  year: 2009
  ident: 10.1016/j.tibs.2011.10.004_bib0085
  article-title: RING domain E3 ubiquitin ligases
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.78.101807.093809
  contributor:
    fullname: Deshaies
– volume: 7
  start-page: 2983
  year: 2008
  ident: 10.1016/j.tibs.2011.10.004_bib0230
  article-title: SCFFbx4/alphaαB-crystallin E3 ligase: when one is not enough
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.19.6775
  contributor:
    fullname: Barbash
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Snippet In response to genotoxic stress, eukaryotic cells activate the DNA damage response (DDR), a series of pathways that coordinate cell cycle arrest and DNA repair...
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SubjectTerms aneuploidy
Animals
antineoplastic agents
cell cycle checkpoints
centrosomes
chromosome segregation
DDR
DNA Damage
DNA repair
eukaryotic cells
genome
Genomic Instability
genotoxicity
Humans
mutation
proteasome endopeptidase complex
proteins
SKP Cullin F-Box Protein Ligases - chemistry
SKP Cullin F-Box Protein Ligases - genetics
SKP Cullin F-Box Protein Ligases - metabolism
therapeutics
ubiquitin-protein ligase
Ubiquitination - genetics
Title SCF ubiquitin ligases in the maintenance of genome stability
URI https://dx.doi.org/10.1016/j.tibs.2011.10.004
https://www.ncbi.nlm.nih.gov/pubmed/22099186
https://search.proquest.com/docview/1028036544
https://search.proquest.com/docview/921424158
https://pubmed.ncbi.nlm.nih.gov/PMC3278546
Volume 37
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