Metagenomic Next-Generation Sequencing for Pathogen Detection and Transcriptomic Analysis in Pediatric Central Nervous System Infections

• Published in: Open forum infectious diseases Vol. 8; no. 6; p. ofab104
• Main Authors: Ramchandar, Nanda, Coufal, Nicole G, Warden, Anna S, Briggs, Benjamin, Schwarz, Toni, Stinnett, Rita, Xie, Heng, Schlaberg, Robert, Foley, Jennifer, Clarke, Christina, Waldeman, Bryce, Enriquez, Claudia, Osborne, Stephanie, Arrieta, Antonio, Salyakina, Daria, Janvier, Michelin, Sendi, Prithvi, Totapally, Balagangadhar R, Dimmock, David, Farnaes, Lauge
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2021
• Subjects: Infections; Major; Nervous system; Pathogens; Pediatrics; encephalitis; next-generation sequencing; metagenomics; meningitis; pediatric

BackgroundPediatric central nervous system (CNS) infections are potentially life-threatening and may incur significant morbidity. Identifying a pathogen is important, both in terms of guiding therapeutic management and in characterizing prognosis. Usual care testing by culture and polymerase chain r...