The multiphasic profile of free fatty acids during the intravenous glucose tolerance test is unresponsive to exogenous insulin

• Published in: Metabolism, clinical and experimental Vol. 53; no. 9; pp. 1202 - 1207
• Main Authors: Sumner, A.E., Bergman, R.N., Vega, G.L., Genovese, D.J., Cochran, C.S., Pacak, K., Watanabe, R.M., Boston, R.C.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2004; Elsevier
• Subjects: Adult; Biological and medical sciences; Blood Glucose - metabolism; Body Mass Index; Epinephrine - blood; Fatty Acids, Nonesterified - blood; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents - blood; Hypoglycemic Agents - pharmacology; Immunochemistry; Insulin - blood; Insulin - pharmacology; Investigative techniques, diagnostic techniques (general aspects); Luminescent Measurements; Male; Medical sciences; Metabolic diseases; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Epinephrine; Human; Exogenous; Pancreatic hormone; Fasting; Intravenous administration; Lipids; Glucose tolerance test; Free fatty acid; Concentration; Glucose; Diurnal variation; Catecholamine; Insulin; Lipolysis; Endogenous; Fast; Saline solution; Comparative study

As small increments in insulin concentration profoundly affect lipolysis, our goal was to describe the free fatty acid (FFA) profile during the frequently sampled intravenous glucose tolerance test (FSIGT) and determine if both endogenous and exogenous insulin influenced the FFA profile. Thirteen su...