Screening and Evaluation of Potential Efflux Pump Inhibitors with a Seaweed Compound Diphenylmethane-Scaffold against Drug-Resistant Escherichia coli

• Published in: Antibiotics (Basel) Vol. 13; no. 7; p. 628
• Main Authors: Lu, Wen-Jung, Lian, Yu-Wei, Chang, Chun-Ju, Lin, Hsuan-Ju, Huang, Chian-Yun, Hsu, Pang-Hung, Lin, Hong-Ting
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Acetonitrile; Algae; Antibiotic resistance; Antibiotics; Bacteria; Binding sites; Cytotoxicity; Damage accumulation; Diphenyl methane; Drug dosages; drug efflux; Drug resistance; Drug resistance in microorganisms; drug transporters; E coli; Efflux; efflux pump inhibitors; Erythromycin; Escherichia coli; Ethidium bromide; Free energy; Gram-negative bacteria; Inhibitors; Membrane permeability; Modulation; molecular docking; multidrug resistance; Penicillin G; Pharmaceutical industry; Scaffolds; Seaweeds; Tetracycline; Tetracyclines; Toxicity; Toxicity testing; Taiwan; drug transporters; multidrug resistance; drug efflux; molecular docking; efflux pump inhibitors

Drug-resistant efflux pumps play a crucial role in bacterial antibiotic resistance. In this study, potential efflux pump inhibitors (EPIs) with a diphenylmethane scaffold were screened and evaluated against drug-resistant Escherichia coli. Twenty-four compounds were docked against the drug-binding s...