Brain Swelling versus Infarct Size: A Problematizing Review

• Published in: Brain sciences Vol. 14; no. 3; p. 229
• Main Authors: Simard, J Marc, Wilhelmy, Bradley, Tsymbalyuk, Natalya, Shim, Bosung, Stokum, Jesse A, Evans, Madison, Gaur, Anandita, Tosun, Cigdem, Keledjian, Kaspar, Ciryam, Prajwal, Serra, Riccardo, Gerzanich, Volodymyr
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2024; MDPI
• Subjects: Animal models; brain edema; Brain research; brain swelling; cerebral ischemia; Edema; Genes; Health aspects; Ischemia; middle cerebral artery occlusion; Mortality; Review; Stroke; SUR1-TRPM4; Translation; brain edema; cerebral ischemia; review; SUR1-TRPM4; stroke; middle cerebral artery occlusion; brain swelling

In human stroke, brain swelling is an important predictor of neurological outcome and mortality, yet treatments to reduce or prevent brain swelling are extremely limited, due in part to an inadequate understanding of mechanisms. In preclinical studies on cerebroprotection in animal models of stroke,...