BMI Is Causally Associated With Pulmonary Artery Pressure But Not Hemodynamic Evidence of Pulmonary Vascular Remodeling

• Published in: Chest Vol. 159; no. 1; pp. 302 - 310
• Main Authors: Thayer, Timothy E., Levinson, Rebecca T., Huang, Shi, Assad, Tufik, Farber-Eger, Eric, Wells, Quinn S., Mosley, Jonathan D., Brittain, Evan L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; American College of Chest Physicians
• Subjects: Aged; Body Mass Index; Causality; Cohort Studies; echocardiogram; Female; Genome-Wide Association Study; Humans; Male; mendelian randomization; Mendelian Randomization Analysis; Middle Aged; obesity; Obesity - complications; Pulmonary and Cardiovascular: Original Research; Pulmonary Arterial Hypertension - epidemiology; Pulmonary Artery; pulmonary hypertension; right heart catheterization; Risk Factors; Vascular Remodeling; sGRS; GWAS; PVH; pulmonary hypertension; GRS; RHC; right heart catheterization; hpGRS; echocardiogram; MEGA; PAH; PH; sPAP; mendelian randomization; obesity
• ISSN: 0012-3692; 1931-3543; 1931-3543
• DOI: 10.1016/j.chest.2020.07.038

There is an unclear relationship of obesity to the pathogenesis and severity of pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH). Is BMI casually associated with pulmonary artery pressure (PAP) and/or markers of pulmonary vascular remodeling? The study design was a two-s...