Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging

• Published in: Chest Vol. 160; no. 6; pp. 2220 - 2231
• Main Authors: Rahaghi, Farbod N., Nardelli, Pietro, Harder, Eileen, Singh, Inderjit, Sánchez-Ferrero, Gonzalo Vegas, Ross, James C., San José Estépar, Rubén, Ash, Samuel Y., Hunsaker, Andetta R., Maron, Bradley A., Leopold, Jane A., Waxman, Aaron B., San José Estépar, Raúl, Washko, George R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021; American College of Chest Physicians
• Subjects: Adult; Aged; arterial; CT imaging; exercise pulmonary hypertension; Female; Humans; Male; Middle Aged; pulmonary arterial hypertension; Pulmonary Arterial Hypertension - diagnostic imaging; Pulmonary Arterial Hypertension - physiopathology; Pulmonary Artery - diagnostic imaging; Pulmonary Artery - physiopathology; Pulmonary Vascular: Original Research; Pulmonary Veins - diagnostic imaging; Pulmonary Veins - physiopathology; Respiratory Function Tests; Retrospective Studies; Tomography, X-Ray Computed; tortuosity; venous; venous; CT imaging; PAH; tortuosity; arterial; ePH; exercise pulmonary hypertension; pulmonary arterial hypertension
• DOI: 10.1016/j.chest.2021.06.069
• ISSN: 0012-3692; 1931-3543

Pulmonary hypertension is a heterogeneous disease, and a significant portion of patients at risk for it have CT imaging available. Advanced automated processing techniques could be leveraged for early detection, screening, and development of quantitative phenotypes. Pruning and vascular tortuosity have been previously described in pulmonary arterial hypertension (PAH), but the extent of these phenomena in arterial vs venous pulmonary vasculature and in exercise pulmonary hypertension (ePH) have not been described. What are the arterial and venous manifestations of pruning and vascular tortuosity using CT imaging in PAH, and do they also occur in ePH? A cohort of patients with PAH and ePH and control subjects with available CT angiograms were retrospectively identified to examine the differential arterial and venous presence of pruning and tortuosity in patients with precapillary pulmonary hypertension not confounded by lung or thromboembolic disease. The pulmonary vasculature was reconstructed, and an artificial intelligence method was used to separate arteries and veins and to compute arterial and venous vascular volumes and tortuosity. A total of 42 patients with PAH, 12 patients with ePH, and 37 control subjects were identified. There was relatively lower (median [interquartile range]) arterial small vessel volume in subjects with PAH (PAH 14.7 [11.7-16.5; P < .0001]) vs control subjects (16.9 [15.6-19.2]) and venous small vessel volume in subjects with PAH and ePH (PAH 8.0 [6.5-9.6; P < .0001]; ePH, 7.8 [7.5-11.4; P = .004]) vs control subjects (11.5 [10.6-12.2]). Higher large arterial volume, however, was only observed in the pulmonary arteries (PAH 17.1 [13.6-23.4; P < .0001] vs control subjects 11.4 [8.1-15.4]). Similarly, tortuosity was higher in the pulmonary arteries in the PAH group (PAH 3.5 [3.3-3.6; P = .0002] vs control 3.2 [3.2-3.3]). Lower small distal pulmonary vascular volume, higher proximal arterial volume, and higher arterial tortuosity were observed in PAH. These can be quantified by using automated techniques from clinically acquired CT scans of patients with ePH and resting PAH. [Display omitted]