Current and Future Clinical Applications of ctDNA in Immuno-Oncology

• Published in: Cancer research (Chicago, Ill.) Vol. 82; no. 3; pp. 349 - 358
• Main Authors: Stadler, Julia-Christina, Belloum, Yassine, Deitert, Benjamin, Sementsov, Mark, Heidrich, Isabel, Gebhardt, Christoffer, Keller, Laura, Pantel, Klaus
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.02.2022
• Subjects: Biomarkers, Tumor - genetics; Circulating Tumor DNA - metabolism; Humans; Immunotherapy - methods; Life Sciences; Review

Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive opportunity to diagnose, characterize, and monitor the disease in individual cancer patients. ctDNA can reflect the actual tumor burden and specific genomic state of disease and thus might serve as a prognostic an...