Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats via TDP-43 Overexpression

• Published in: Molecular therapy Vol. 17; no. 4; pp. 607 - 613
• Main Authors: Tatom, Jason B, Wang, David B, Dayton, Robert D, Skalli, Omar, Hutton, Michael L, Dickson, Dennis W, Klein, Ronald L
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2009; Elsevier Limited; Nature Publishing Group
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - pathology; Animals; Antibodies; Apoptosis; Behavior; Cytoplasm; Dementia - genetics; Dementia - pathology; Dependovirus - genetics; Disease; DNA-Binding Proteins - genetics; Dopamine; Gene therapy; Genetic Vectors; Health sciences; Humans; Mutation; Neurodegeneration; Neuropathology; Neurosciences; Original; Pathology; Proteins; Rats; Toxicology; Transfection; Louisiana; Florida; United States > US

Since the discovery of neuropathological lesions made of TDP-43 and ubiquitin proteins in cases of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), there is a burst of effort on finding related familial mutations and developing animal models. We used an adeno-associa...