Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function

• Published in: Scientific reports Vol. 10; no. 1; p. 437
• Main Authors: Findlay, Amy S., McKie, Lisa, Keighren, Margaret, Clementson-Mobbs, Sharon, Sanchez-Pulido, Luis, Wells, Sara, Cross, Sally H., Jackson, Ian J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.01.2020; Nature Publishing Group
• Subjects: 45/70; 631/208; 64/60; 692/699/3161; Amino Acid Sequence; Animals; Caenorhabditis elegans Proteins - genetics; Cell Count; Electroretinograms; Eye; Gene Knockout Techniques; Humanities and Social Sciences; Humans; Mammals; Membrane Proteins - genetics; Mice; Models, Molecular; multidisciplinary; Mutants; Mutation; Phenotypes; Phenotyping; Phosphodiesterase; Photoreceptor Cells, Vertebrate - cytology; Photoreceptors; Protein Conformation; Retina; Retina - cytology; Retina - physiology; Retinal degeneration; Science; Science (multidisciplinary); Sequence analysis; Sequence Homology, Nucleic Acid

Fam151b is a mammalian homologue of the C. elegans menorin gene, which is involved in neuronal branching. The International Mouse Phenotyping Consortium (IMPC) aims to knock out every gene in the mouse and comprehensively phenotype the mutant animals. This project identified Fam151b homozygous knock...