Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio)

• Published in: Aquatic toxicology Vol. 209; pp. 99 - 112
• Main Authors: Parsons, Aoife, Lange, Anke, Hutchinson, Thomas H., Miyagawa, Shinichi, Iguchi, Taisen, Kudoh, Tetsuhiro, Tyler, Charles R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2019
• Subjects: Animals; brain; Brominated flame retardant; Danio rerio; death; Development; early development; Embryo, Nonmammalian - drug effects; Endocrine; enzymes; Fish; flame retardants; Flame Retardants - toxicity; Gene Expression Regulation, Developmental - drug effects; genes; Halogenated Diphenyl Ethers - toxicity; homeostasis; in situ hybridization; Iodide Peroxidase - genetics; Iodide Peroxidase - metabolism; Larva - drug effects; liver; messenger RNA; metabolism; mortality; Organ Specificity - drug effects; pericardium; Polybrominated Biphenyls - toxicity; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; RNA, Messenger - genetics; RNA, Messenger - metabolism; skeletal development; tail; Thyroid; thyroid hormones; Toxicity Tests, Acute; Toxicology; transcription (genetics); transport proteins; vertebrates; Water Pollutants, Chemical - toxicity; yolk sac; Zebrafish - embryology; Zebrafish - genetics; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; Development; Endocrine; Fish; Toxicology; Brominated flame retardant; Thyroid

•Zebrafish thyroid system is vulnerable to disruption by BFRs during early development.•BFRs disrupt thyroid axis of zebrafish embryo-larvae at multiple mRNA transcripts.•Effects of BFRs on the thyroid system are tissue- and developmental stage-specific.•Implications of transcriptional changes targe...