A Polymorphism in Toll-Interleukin 1 Receptor Domain Containing Adaptor Protein Is Associated with Susceptibility to Meningeal Tuberculosis

• Published in: The Journal of infectious diseases Vol. 194; no. 8; pp. 1127 - 1134
• Main Authors: Hawn, Thomas R., Dunstan, Sarah J., Thwaites, Guy E., Simmons, Cameron P., Thuong, Nguyen Thuong, Lan, Nguyen Thi Ngoc, Quy, Hoang Thi, Chau, Tran Thi Hong, Hieu, Nguyen T., Rodrigues, Stephanie, Janer, Marta, Zhao, Lue Ping, Hien, Tran Tinh, Farrar, Jeremy J., Aderem, Alan
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 15.10.2006; University of Chicago Press
• Subjects: Adult; Alleles; Asian Continental Ancestry Group - genetics; Bacteria; Bacterial diseases; Biological and medical sciences; Case-Control Studies; Cytokines; Disease susceptibility; Female; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease; Genotypes; Haplotypes; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Meningeal tuberculosis; Microbiology; Mycobacterium tuberculosis; Polymorphism, Genetic; Pulmonary tuberculosis; Receptors; Receptors, Interleukin-1 - genetics; Toll like receptors; Toll-Like Receptors - genetics; Tuberculosis and atypical mycobacterial infections; Tuberculosis, Meningeal - genetics; Tuberculosis, Pulmonary - genetics; Vietnam; Vietnam; Infection; Sensitivity; Tuberculosis; Microbiology; Cytokine; Interleukin 1; Bacteriosis; Mycobacterial infection; Protein; Polymorphism

BackgroundAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protei...