A Polymorphism in Toll-Interleukin 1 Receptor Domain Containing Adaptor Protein Is Associated with Susceptibility to Meningeal Tuberculosis

BackgroundAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protei...

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Published inThe Journal of infectious diseases Vol. 194; no. 8; pp. 1127 - 1134
Main Authors Hawn, Thomas R., Dunstan, Sarah J., Thwaites, Guy E., Simmons, Cameron P., Thuong, Nguyen Thuong, Lan, Nguyen Thi Ngoc, Quy, Hoang Thi, Chau, Tran Thi Hong, Hieu, Nguyen T., Rodrigues, Stephanie, Janer, Marta, Zhao, Lue Ping, Hien, Tran Tinh, Farrar, Jeremy J., Aderem, Alan
Format Journal Article
LanguageEnglish
Published Chicago, IL The University of Chicago Press 15.10.2006
University of Chicago Press
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Abstract BackgroundAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB) MethodsWe used a case-population study design in Vietnam with cord-blood control samples (n=392) and case patients (n=358) who had either pulmonary (n=183) or meningeal (n=175) TB ResultsThe TIRAP single-nucleotide polymorphism (SNP) C558T was associated with increased susceptibility to TB, with a 558T allele frequency of 0.035 in control samples versus 0.074 in case patients (odds ratio [OR], 2.25; P<.001). Subgroup analysis revealed that SNP 558T was more strongly associated with susceptibility to meningeal TB (OR, 3.02; P<.001) than to pulmonary TB (OR, 1.55; P=.22). In comparison to the 558CC genotype, the 558TT genotype was associated with decreased whole-blood interleukin-6 production, which suggests that TIRAP influences disease susceptibility by modulating the inflammatory response ConclusionsThese results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms
AbstractList Although meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB). We used a case-population study design in Vietnam with cord-blood control samples (n = 392) and case patients (n = 358) who had either pulmonary (n = 183) or meningeal (n = 175) TB. The TIRAP single-nucleotide polymorphism (SNP) C558T was associated with increased susceptibility to TB, with a 558T allele frequency of 0.035 in control samples versus 0.074 in case patients (odds ratio [OR], 2.25; P < .001). Subgroup analysis revealed that SNP 558T was more strongly associated with susceptibility to meningeal TB (OR, 3.02; P < .001) than to pulmonary TB (OR, 1.55; P = .22). In comparison to the 558CC genotype, the 558TT genotype was associated with decreased whole-blood interleukin-6 production, which suggests that TIRAP influences disease susceptibility by modulating the inflammatory response. These results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms.
BackgroundAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB) MethodsWe used a case-population study design in Vietnam with cord-blood control samples (n=392) and case patients (n=358) who had either pulmonary (n=183) or meningeal (n=175) TB ResultsThe TIRAP single-nucleotide polymorphism (SNP) C558T was associated with increased susceptibility to TB, with a 558T allele frequency of 0.035 in control samples versus 0.074 in case patients (odds ratio [OR], 2.25; P<.001). Subgroup analysis revealed that SNP 558T was more strongly associated with susceptibility to meningeal TB (OR, 3.02; P<.001) than to pulmonary TB (OR, 1.55; P=.22). In comparison to the 558CC genotype, the 558TT genotype was associated with decreased whole-blood interleukin-6 production, which suggests that TIRAP influences disease susceptibility by modulating the inflammatory response ConclusionsThese results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms
BACKGROUNDAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB).METHODSWe used a case-population study design in Vietnam with cord-blood control samples (n = 392) and case patients (n = 358) who had either pulmonary (n = 183) or meningeal (n = 175) TB.RESULTSThe TIRAP single-nucleotide polymorphism (SNP) C558T was associated with increased susceptibility to TB, with a 558T allele frequency of 0.035 in control samples versus 0.074 in case patients (odds ratio [OR], 2.25; P < .001). Subgroup analysis revealed that SNP 558T was more strongly associated with susceptibility to meningeal TB (OR, 3.02; P < .001) than to pulmonary TB (OR, 1.55; P = .22). In comparison to the 558CC genotype, the 558TT genotype was associated with decreased whole-blood interleukin-6 production, which suggests that TIRAP influences disease susceptibility by modulating the inflammatory response.CONCLUSIONSThese results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms.
BackgroundAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB) MethodsWe used a case-population study design in Vietnam with cord-blood control samples (n=392) and case patients (n=358) who had either pulmonary (n=183) or meningeal (n=175) TB ResultsThe TIRAP single-nucleotide polymorphism (SNP) C558T was associated with increased susceptibility to TB, with a 558T allele frequency of 0.035 in control samples versus 0.074 in case patients (odds ratio [OR], 2.25; P<.001). Subgroup analysis revealed that SNP 558T was more strongly associated with susceptibility to meningeal TB (OR, 3.02; P<.001) than to pulmonary TB (OR, 1.55; P=.22). In comparison to the 558CC genotype, the 558TT genotype was associated with decreased whole-blood interleukin-6 production, which suggests that TIRAP influences disease susceptibility by modulating the inflammatory response ConclusionsThese results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms
Although meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB). We used a case-population study design in Vietnam with cord-blood control samples (n = 392) and case patients (n = 358) who had either pulmonary (n = 183) or meningeal (n = 175) TB. The TIRAP single-nucleotide polymorphism (SNP) C558T was associated with increased susceptibility to TB, with a 558T allele frequency of 0.035 in control samples versus 0.074 in case patients (odds ratio [OR], 2.25; P < .001). Subgroup analysis revealed that SNP 558T was more strongly associated with susceptibility to meningeal TB (OR, 3.02; P < .001) than to pulmonary TB (OR, 1.55; P = .22). In comparison to the 558CC genotype, the 558TT genotype was associated with decreased whole-blood interleukin-6 production, which suggests that TIRAP influences disease susceptibility by modulating the inflammatory response. These results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms.
Author Hien, Tran Tinh
Zhao, Lue Ping
Quy, Hoang Thi
Farrar, Jeremy J.
Hawn, Thomas R.
Simmons, Cameron P.
Thwaites, Guy E.
Rodrigues, Stephanie
Dunstan, Sarah J.
Thuong, Nguyen Thuong
Lan, Nguyen Thi Ngoc
Hieu, Nguyen T.
Janer, Marta
Aderem, Alan
Chau, Tran Thi Hong
AuthorAffiliation 3 Fred Hutchinson Cancer Research Center, Seattle, Washington
8 Hung Vuong Hospital, Ho Chi Minh City, Vietnam
1 Department of Medicine, University of Washington School of Medicine, Seattle, Washington
10 The London School of Hygiene and Tropical Medicine, London, United Kingdom
9 Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford
4 Enodar BioLogic Corporation, Seattle, Washington
2 Institute for Systems Biology, Seattle, Washington
6 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
7 Pham Ngoc Thach Hospital for Tuberculosis and Lung Disease, Ho Chi Minh City, Vietnam
5 Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
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Issue 8
Keywords Infection
Sensitivity
Tuberculosis
Microbiology
Cytokine
Interleukin 1
Bacteriosis
Mycobacterial infection
Protein
Polymorphism
Language English
License CC BY 4.0
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References 15310472 - Microbes Infect. 2004 Aug;6(10):946-59
11544529 - Nature. 2001 Sep 6;413(6851):78-83
16138914 - Ann Hum Genet. 2005 Sep;69(Pt 5):559-65
12524386 - Annu Rev Immunol. 2003;21:335-76
11861602 - Annu Rev Immunol. 2002;20:197-216
10490993 - J Immunol. 1999 Oct 1;163(7):3920-7
12435101 - Clin Chem Lab Med. 2002 Sep;40(9):863-8
10963608 - Nature. 2000 Aug 17;406(6797):782-7
9521923 - Genome Res. 1998 Mar;8(3):195-202
10675209 - J Neurol Neurosurg Psychiatry. 2000 Mar;68(3):289-99
12491915 - Methods Mol Biol. 2003;212:241-62
565607 - Am Rev Respir Dis. 1978 Apr;117(4):621-4
11861613 - Annu Rev Immunol. 2002;20:581-620
15229469 - Nat Rev Immunol. 2004 Jul;4(7):499-511
10426995 - Science. 1999 Jul 30;285(5428):732-6
12047967 - Lancet. 2002 May 4;359(9317):1569-73
14979495 - Eur Respir J. 2004 Feb;23(2):219-23
7718830 - Tuber Lung Dis. 1994 Dec;75(6):423-8
11736990 - Cell Microbiol. 2001 Dec;3(12):773-84
15510710 - Monaldi Arch Chest Dis. 2004 Apr-Jun;61(2):102-11
15219996 - Mol Immunol. 2004 Jul;41(6-7):577-82
12646604 - J Immunol. 2003 Apr 1;170(7):3451-4
14623910 - J Exp Med. 2003 Nov 17;198(10):1563-72
5004883 - Bull Int Union Tuberc. 1969 Aug;42:1-104
9486992 - N Engl J Med. 1998 Mar 5;338(10):640-4
14551879 - J Infect Dis. 2003 Oct 15;188(8):1105-15
16424233 - J Immunol. 2006 Feb 1;176(3):2007-14
9952386 - J Infect Dis. 1999 Mar;179(3):721-4
10203135 - Pediatr Res. 1999 Apr;45(4 Pt 1):459-64
16112032 - Hum Immunol. 2005 Jul;66(7):842-7
15837108 - Clin Chest Med. 2005 Jun;26(2):233-46, vi
15496623 - N Engl J Med. 2004 Oct 21;351(17):1741-51
12106786 - Microbes Infect. 2002 Jul;4(9):937-44
15699327 - Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2487-9
22223856 - J Infect Dis. 2012 Feb 15;205(4):525-7
12447442 - Nature. 2002 Nov 21;420(6913):329-33
11733749 - Nat Rev Genet. 2001 Dec;2(12):967-77
12447441 - Nature. 2002 Nov 21;420(6913):324-9
12788577 - Lancet. 2003 May 31;361(9372):1871-2
11463015 - N Engl J Med. 2001 Jul 19;345(3):189-200
12088679 - Curr Opin Immunol. 2002 Aug;14(4):452-7
12692544 - Nat Med. 2003 May;9(5):525-32
12023780 - J Infect Dis. 2002 Jun 1;185(11):1684-7
10696983 - Lancet. 2000 Feb 19;355(9204):618-21
16027372 - Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10593-7
12637671 - Science. 2003 Mar 28;299(5615):2076-9
15454920 - Nat Immunol. 2004 Oct;5(10 ):975-9
10588727 - Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14459-63
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Snippet BackgroundAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis the immunopathogenesis of this disease is poorly...
Although meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We...
BACKGROUNDAlthough meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly...
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SubjectTerms Adult
Alleles
Asian Continental Ancestry Group - genetics
Bacteria
Bacterial diseases
Biological and medical sciences
Case-Control Studies
Cytokines
Disease susceptibility
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Genotypes
Haplotypes
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Meningeal tuberculosis
Microbiology
Mycobacterium tuberculosis
Polymorphism, Genetic
Pulmonary tuberculosis
Receptors
Receptors, Interleukin-1 - genetics
Toll like receptors
Toll-Like Receptors - genetics
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Meningeal - genetics
Tuberculosis, Pulmonary - genetics
Vietnam
Title A Polymorphism in Toll-Interleukin 1 Receptor Domain Containing Adaptor Protein Is Associated with Susceptibility to Meningeal Tuberculosis
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