Role for Nonstructural Protein 1 of Severe Acute Respiratory Syndrome Coronavirus in Chemokine Dysregulation
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| Published in | Journal of Virology Vol. 81; no. 1; pp. 416 - 422 |
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| Format | Journal Article |
| Language | English |
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American Society for Microbiology
01.01.2007
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| AbstractList | Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-kappaB. Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-κB. Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF- Kappa B. Erratum ( vol. 81 , p. 2537 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI |
| Author | Howard C. H. Yim Anna H. Y. Law Davy C. W. Lee Benny K. W. Cheung Allan S. Y. Lau |
| AuthorAffiliation | Immunology Research Laboratory, Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China |
| AuthorAffiliation_xml | – name: Immunology Research Laboratory, Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China |
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| Keywords | Infection Virus Chemokine Lung disease Coronavirus Respiratory disease Viral disease Severe acute respiratory syndrome Coronaviridae Nidovirales Protein Virology |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Mailing address: Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China. Phone: 852-2855-4269. Fax: 852-2855-1523. E-mail: asylau@hku.hk. |
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Delicious... Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have... |
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| SubjectTerms | Biological and medical sciences Cellular Response to Infection Chemokine CCL3 Chemokine CCL5 Chemokine CXCL10 Chemokines - genetics Chemokines - metabolism Chemokines, CC - genetics Chemokines, CC - metabolism Chemokines, CXC - genetics Chemokines, CXC - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Microbiology Miscellaneous NF-kappa B - genetics NF-kappa B - metabolism Respiratory Mucosa - cytology Respiratory Mucosa - virology SARS coronavirus SARS Virus - metabolism SARS Virus - pathogenicity Viral Envelope Proteins - physiology Viral Matrix Proteins - physiology Viral Nonstructural Proteins - metabolism Virology |
| Title | Role for Nonstructural Protein 1 of Severe Acute Respiratory Syndrome Coronavirus in Chemokine Dysregulation |
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