Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis

Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera , source of pharmaceutically important withanolides biosynthesizes withaferin-A in leaves and withanolide-A in roots. To increase the in planta withanolides production, a sustaina...

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Published inScientific reports Vol. 8; no. 1; pp. 5450 - 19
Main Authors Pandey, Shiv S., Singh, Sucheta, Pandey, Harshita, Srivastava, Madhumita, Ray, Tania, Soni, Sumit, Pandey, Alok, Shanker, Karuna, Babu, C. S. Vivek, Banerjee, Suchitra, Gupta, M. M., Kalra, Alok
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.04.2018
Nature Publishing Group
Subjects
13/106
38/23
631/326/2522
631/449/2667
Acetic acid
Biosynthesis
Endophytes
Humanities and Social Sciences
Indoleacetic acid
Leaves
Medicinal plants
Metabolites
multidisciplinary
Nitrogen fixation
Photosynthesis
Plant growth
Plants
Roots
Science
Science (multidisciplinary)
Secondary metabolites
Withania somnifera
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Abstract Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera , source of pharmaceutically important withanolides biosynthesizes withaferin-A in leaves and withanolide-A in roots. To increase the in planta withanolides production, a sustainable approach needs to be explored. Here, we isolated endophytes from different parts of W. somnifera plants and their promising role in in planta withanolide biosynthesis was established in both in-vivo grown as well in in-vitro raised composite W. somnifera plants. Overall, the fungal endophytes improved photosynthesis, plant growth and biomass, and the root-associated bacterial endophytes enhanced the withanolide content in both in-vivo and in-vitro grown plants by modulating the expression of withanolide biosynthesis genes in leaves and roots. Surprisingly, a few indole-3-acetic acid (IAA)-producing and nitrogen-fixing root-associated endophytes could induce the biosynthesis of withaferin-A in roots by inducing in planta IAA-production and upregulating the expression of withanolide biosynthesis genes especially MEP-pathway genes ( DXS and DXR ) in roots as well. Results indicate the role of endophytes in modulating the synthesis and site of withanolides production and the selected endophytes can be used for enhancing the in planta withanolide production and enriching roots with pharmaceutically important withaferin-A which is generally absent in roots.
AbstractList Abstract Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera , source of pharmaceutically important withanolides biosynthesizes withaferin-A in leaves and withanolide-A in roots. To increase the in planta withanolides production, a sustainable approach needs to be explored. Here, we isolated endophytes from different parts of W. somnifera plants and their promising role in in planta withanolide biosynthesis was established in both in-vivo grown as well in in-vitro raised composite W. somnifera plants. Overall, the fungal endophytes improved photosynthesis, plant growth and biomass, and the root-associated bacterial endophytes enhanced the withanolide content in both in-vivo and in-vitro grown plants by modulating the expression of withanolide biosynthesis genes in leaves and roots. Surprisingly, a few indole-3-acetic acid (IAA)-producing and nitrogen-fixing root-associated endophytes could induce the biosynthesis of withaferin-A in roots by inducing in planta IAA-production and upregulating the expression of withanolide biosynthesis genes especially MEP-pathway genes ( DXS and DXR ) in roots as well. Results indicate the role of endophytes in modulating the synthesis and site of withanolides production and the selected endophytes can be used for enhancing the in planta withanolide production and enriching roots with pharmaceutically important withaferin-A which is generally absent in roots.
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera, source of pharmaceutically important withanolides biosynthesizes withaferin-A in leaves and withanolide-A in roots. To increase the in planta withanolides production, a sustainable approach needs to be explored. Here, we isolated endophytes from different parts of W. somnifera plants and their promising role in in planta withanolide biosynthesis was established in both in-vivo grown as well in in-vitro raised composite W. somnifera plants. Overall, the fungal endophytes improved photosynthesis, plant growth and biomass, and the root-associated bacterial endophytes enhanced the withanolide content in both in-vivo and in-vitro grown plants by modulating the expression of withanolide biosynthesis genes in leaves and roots. Surprisingly, a few indole-3-acetic acid (IAA)-producing and nitrogen-fixing root-associated endophytes could induce the biosynthesis of withaferin-A in roots by inducing in planta IAA-production and upregulating the expression of withanolide biosynthesis genes especially MEP-pathway genes (DXS and DXR) in roots as well. Results indicate the role of endophytes in modulating the synthesis and site of withanolides production and the selected endophytes can be used for enhancing the in planta withanolide production and enriching roots with pharmaceutically important withaferin-A which is generally absent in roots.
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera , source of pharmaceutically important withanolides biosynthesizes withaferin-A in leaves and withanolide-A in roots. To increase the in planta withanolides production, a sustainable approach needs to be explored. Here, we isolated endophytes from different parts of W. somnifera plants and their promising role in in planta withanolide biosynthesis was established in both in-vivo grown as well in in-vitro raised composite W. somnifera plants. Overall, the fungal endophytes improved photosynthesis, plant growth and biomass, and the root-associated bacterial endophytes enhanced the withanolide content in both in-vivo and in-vitro grown plants by modulating the expression of withanolide biosynthesis genes in leaves and roots. Surprisingly, a few indole-3-acetic acid (IAA)-producing and nitrogen-fixing root-associated endophytes could induce the biosynthesis of withaferin-A in roots by inducing in planta IAA-production and upregulating the expression of withanolide biosynthesis genes especially MEP-pathway genes ( DXS and DXR ) in roots as well. Results indicate the role of endophytes in modulating the synthesis and site of withanolides production and the selected endophytes can be used for enhancing the in planta withanolide production and enriching roots with pharmaceutically important withaferin-A which is generally absent in roots.
ArticleNumber 5450
Author Shanker, Karuna
Singh, Sucheta
Pandey, Alok
Ray, Tania
Pandey, Harshita
Pandey, Shiv S.
Srivastava, Madhumita
Babu, C. S. Vivek
Banerjee, Suchitra
Kalra, Alok
Soni, Sumit
Gupta, M. M.
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  organization: Microbial Technology Department, CSIR-Central Institute of Medicinal and Aromatic Plants
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29615668$$D View this record in MEDLINE/PubMed
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Snippet Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera , source of pharmaceutically important...
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera, source of pharmaceutically important...
Abstract Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal plants. Withania somnifera , source of pharmaceutically...
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StartPage 5450
SubjectTerms 13/106
38/23
631/326/2522
631/449/2667
Acetic acid
Biosynthesis
Endophytes
Humanities and Social Sciences
Indoleacetic acid
Leaves
Medicinal plants
Metabolites
multidisciplinary
Nitrogen fixation
Photosynthesis
Plant growth
Plants
Roots
Science
Science (multidisciplinary)
Secondary metabolites
Withania somnifera
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Title Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis
URI https://link.springer.com/article/10.1038/s41598-018-23716-5
https://www.ncbi.nlm.nih.gov/pubmed/29615668
https://www.proquest.com/docview/2021295105
https://search.proquest.com/docview/2021733558
https://pubmed.ncbi.nlm.nih.gov/PMC5882813
Volume 8
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