Inflammation: improving understanding to prevent or ameliorate kidney diseases

Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered protective, an uncontrolled inflammation...

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Published inThe journal of venomous animals and toxins including tropical diseases Vol. 27; p. e20200162
Main Authors Marques Fernandes, Sheila, Watanabe, Mirian, Fernandes Vattimo, Maria de Fátima
Format Journal Article
LanguageEnglish
Published Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) 2021
SciELO
Subjects
Acute kidney injury
Biomarkers
Inflammation
Kidney diseases
Review
TOXICOLOGY
TROPICAL MEDICINE
Biomarkers
Inflammation
Kidney diseases
Acute kidney injury
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Summary:Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered protective, an uncontrolled inflammation may evolve to tissue damage, leading to chronic inflammatory diseases. Inflammation can be considered the major factor involved in the pathological progression of acute and chronic kidney diseases. Functional characteristics of this organ increase its vulnerability to developing various forms of injuries, including acute kidney injury (AKI) and chronic kidney disease (CKD). In view of translational research, several discoveries should be considered regarding the pathogenesis of the inflammatory process, which results in the validation of biomarkers for early detection of kidney diseases. Biomarkers enable the identification of proinflammatory mediators in kidney affections, based on laboratory research applied to clinical practice. Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18.
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Competing interests: The authors declare that they have no competing interests.
Authors’ contributions: SMF, MW and MFFV participated in the design, writing and revisions of the study. All authors read and approved the final manuscript.
ISSN:1678-9199
1678-9199
DOI:10.1590/1678-9199-JVATITD-2020-0162