Pharmacokinetics, optimal dosages and withdrawal time of amoxicillin in Nile tilapia (Oreochromis niloticus) reared at 25 and 30 °C

• Published in: The Veterinary quarterly Vol. 44; no. 1; pp. 1 - 9
• Main Authors: Rairat, Tirawat, Lu, Yi-Ping, Ho, Wan-Cih, Ke, Hual-Jhong, Chou, Chi-Chung
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2024; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Amoxicillin; Amoxicillin - administration & dosage; Amoxicillin - pharmacokinetics; Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Antimicrobials; Aquaculture; Bacterial diseases; Bioavailability; Cichlids; Dosage; Dose-Response Relationship, Drug; Drug dosages; Drug Residues; Drug withdrawal; Fish; Half-Life; Microbial Sensitivity Tests; Minimum inhibitory concentration; Oral administration; Oreochromis niloticus; penicillins; Pharmacodynamics; Pharmacokinetics; Regression analysis; Residues; Temperature; Temperature dependence; Tilapia; tissue residue; withdrawal period; aquaculture; withdrawal period; tissue residue; Antimicrobials; penicillins; fish

Knowledge of amoxicillin (AMX) pharmacokinetics (PK) and tissue residues in fish, which is necessary for prudent drug use, remains limited. The study aimed to explore the PK characteristics of AMX in Nile tilapia (Oreochromis niloticus) reared at 25 and 30 °C as well as to determine optimal dosages...