New insights into the downregulation of cytochrome P450 2E1 via nuclear factor κB-dependent pathways in immune-mediated liver injury

• Published in: Heliyon Vol. 9; no. 12; p. e22641
• Main Authors: Zou, Huiqiong, Cao, Yingying, Hao, Peipei, Jin, Ziqi, Ding, Ruifeng, Bai, Xuefeng, Zhang, Kun, Xue, Yongzhi
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.12.2023; Elsevier
• Subjects: Ammonium pyrrolidine dithiocarbamate; Bacillus Calmette–Guerin; Cytochrome P450 2E1; Immune-mediated damage; Nuclear factor kappa B; Post-translational modification; Post-translational modification; Bacillus Calmette–Guerin; Ammonium pyrrolidine dithiocarbamate; Immune-mediated damage; Cytochrome P450 2E1; Nuclear factor kappa B

The extent of immune-mediated hepatic damage (such as in viral hepatitis) is characterised by the downregulation of cytochrome P450s (CYPs), a class of drug-metabolising enzymes. However, whether this downregulation aids liver cells in maintaining their homeostasis or whether the damage is aggravate...