TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 87; no. 21; pp. 11930 - 11935
Main Authors Abe, Masako, Tahara, Maino, Sakai, Kouji, Yamaguchi, Hiromi, Kanou, Kazuhiko, Shirato, Kazuya, Kawase, Miyuki, Noda, Masahiro, Kimura, Hirokazu, Matsuyama, Shutoku, Fukuhara, Hideo, Mizuta, Katsumi, Maenaka, Katsumi, Ami, Yasushi, Esumi, Mariko, Kato, Atsushi, Takeda, Makoto
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.11.2013
Subjects
Animals
Cell Line
Epithelial Cells - virology
Host-Pathogen Interactions
Humans
Paramyxovirinae - physiology
Sendai virus
Serine Endopeptidases - metabolism
Viral Load
Viral Plaque Assay
Virus Replication
Virus-Cell Interactions
Online AccessGet full text
ISSN0022-538X
1098-5514
1098-5514
DOI10.1128/JVI.01490-13

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.
Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Author Masako Abe
Makoto Takeda
Shutoku Matsuyama
Kazuhiko Kanou
Kazuya Shirato
Miyuki Kawase
Atsushi Kato
Kouji Sakai
Hideo Fukuhara
Masahiro Noda
Hiromi Yamaguchi
Maino Tahara
Mariko Esumi
Hirokazu Kimura
Katsumi Maenaka
Yasushi Ami
Katsumi Mizuta
Author_xml – sequence: 1
  givenname: Masako
  surname: Abe
  fullname: Abe, Masako
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 2
  givenname: Maino
  surname: Tahara
  fullname: Tahara, Maino
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 3
  givenname: Kouji
  surname: Sakai
  fullname: Sakai, Kouji
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 4
  givenname: Hiromi
  surname: Yamaguchi
  fullname: Yamaguchi, Hiromi
  organization: Department of Pathology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
– sequence: 5
  givenname: Kazuhiko
  surname: Kanou
  fullname: Kanou, Kazuhiko
  organization: Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 6
  givenname: Kazuya
  surname: Shirato
  fullname: Shirato, Kazuya
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 7
  givenname: Miyuki
  surname: Kawase
  fullname: Kawase, Miyuki
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 8
  givenname: Masahiro
  surname: Noda
  fullname: Noda, Masahiro
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 9
  givenname: Hirokazu
  surname: Kimura
  fullname: Kimura, Hirokazu
  organization: Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 10
  givenname: Shutoku
  surname: Matsuyama
  fullname: Matsuyama, Shutoku
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 11
  givenname: Hideo
  surname: Fukuhara
  fullname: Fukuhara, Hideo
  organization: Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan
– sequence: 12
  givenname: Katsumi
  surname: Mizuta
  fullname: Mizuta, Katsumi
  organization: Yamagata Prefectural Institute of Public Health, Yamagata, Japan
– sequence: 13
  givenname: Katsumi
  surname: Maenaka
  fullname: Maenaka, Katsumi
  organization: Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan
– sequence: 14
  givenname: Yasushi
  surname: Ami
  fullname: Ami, Yasushi
  organization: Division of Experimental Animal Research, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 15
  givenname: Mariko
  surname: Esumi
  fullname: Esumi, Mariko
  organization: Department of Pathology, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
– sequence: 16
  givenname: Atsushi
  surname: Kato
  fullname: Kato, Atsushi
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
– sequence: 17
  givenname: Makoto
  surname: Takeda
  fullname: Takeda, Makoto
  organization: Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23966399$$D View this record in MEDLINE/PubMed
BookMark eNqFkctrVDEchYNU7PSxcy0X3Ljwtnk_NkIpWkcqHfrCXchNk5mUO8k0uXek_vWmTltUEFdZ5Dsfh9_ZAVsxRQfAawQPEMLy8Mv19AAiqmCLyAswQVDJljFEt8AEQoxbRuS3bbBTyi2sGOX0FdjGRHFOlJqAk8uvs_OLC9xMS2Nic2SHsDZDiPNmltPgTHGNT7k5d2UVshlSvm9mJpsQfT-6-MM01yGPxZU98NKbvrj9x3cXXH36eHn8uT09O5keH522liE0tEhS633Xcce9F0YaQ7nsPBTCQ8lUZ24oV8IiywTEXEmCBfedtcJ66Rh2ZBd82HhXY7d0N9bFIZter3JYmnyvkwn6z58YFnqe1ppIKAilVfDuUZDT3ejKoJehWNf3Jro0Fo04p0hRJtH_0aqjkDECK_rm91rPfZ4OXQG8AWxOpWTntQ1DPXR6aBl6jaB-WFPXNfWvNTUiNfT-r9CT9x_42w2-CPPF95CdNmWpb9dBS6ExqglVq_4EOsOr-Q
CitedBy_id crossref_primary_10_1128_JVI_01567_16
crossref_primary_10_1128_jvi_01903_23
crossref_primary_10_1007_s11224_022_01921_3
crossref_primary_10_1128_mbio_02327_24
crossref_primary_10_1038_nrd_2015_37
crossref_primary_10_1007_s11224_022_01991_3
crossref_primary_10_1128_JVI_03677_13
crossref_primary_10_1002_jev2_70061
crossref_primary_10_36485_1561_6274_2021_25_2_18_26
crossref_primary_10_7759_cureus_43344
crossref_primary_10_1128_JVI_03050_13
crossref_primary_10_1152_ajplung_00028_2015
crossref_primary_10_3934_microbiol_2020021
crossref_primary_10_1038_s41467_024_48059_w
crossref_primary_10_3390_biomedicines10030549
crossref_primary_10_2174_1875036202114010001
crossref_primary_10_1128_JVI_03799_13
crossref_primary_10_3390_antiox12020483
crossref_primary_10_1038_s41598_024_65296_7
crossref_primary_10_1134_S002689331803010X
crossref_primary_10_3390_cancers12082186
crossref_primary_10_1128_jvi_01853_24
crossref_primary_10_1371_journal_pone_0138380
crossref_primary_10_2222_jsv_69_61
crossref_primary_10_1128_spectrum_01164_24
crossref_primary_10_3390_v16060984
crossref_primary_10_3390_biom15010075
crossref_primary_10_3390_genes12010019
crossref_primary_10_3390_jpm12040622
crossref_primary_10_1128_AAC_00065_15
crossref_primary_10_1016_j_apsb_2025_03_011
crossref_primary_10_1111_1348_0421_12446
crossref_primary_10_1073_pnas_2108728118
crossref_primary_10_1128_JVI_00398_21
crossref_primary_10_1128_jvi_00851_23
crossref_primary_10_1042_BST20190675
crossref_primary_10_3390_genes12040596
crossref_primary_10_1016_j_coviro_2021_09_003
crossref_primary_10_3390_v15102124
crossref_primary_10_1002_jmv_28124
crossref_primary_10_1002_hep_27426
crossref_primary_10_1038_s41467_024_49757_1
crossref_primary_10_3390_pathogens11080877
crossref_primary_10_1074_jbc_REV120_015980
crossref_primary_10_3390_ijms23031351
crossref_primary_10_7883_yoken_JJID_2018_500
crossref_primary_10_1128_AAC_01043_16
crossref_primary_10_3390_v15102032
crossref_primary_10_1016_j_coviro_2017_03_018
crossref_primary_10_3390_cancers12123659
crossref_primary_10_3390_cells11081262
crossref_primary_10_3390_ijms24108711
crossref_primary_10_1080_17460794_2024_2398949
crossref_primary_10_3233_TUB_211502
crossref_primary_10_7883_yoken_JJID_2023_353
Cites_doi 10.1074/mcp.M500004-MCP200
10.1128/jvi.66.12.7211-7216.1992
10.1073/pnas.95.17.10224
10.1128/JVI.00140-10
10.1016/0042-6822(73)90296-1
10.1016/j.molmed.2009.05.003
10.1042/BJ20100046
10.1128/JVI.02062-10
10.1128/JVI.00676-08
10.1128/JVI.01118-06
10.1074/jbc.R000020200
10.1128/JVI.05300-11
10.1128/JVI.00246-08
10.1128/JVI.02232-10
10.1128/JVI.00306-12
10.1128/JVI.00094-12
10.1128/JVI.00239-10
10.1002/pmic.200401011
10.1128/JVI.03005-12
10.1016/S0021-9258(18)42250-8
10.1099/0022-1317-78-11-2813
10.1128/JVI.00128-13
10.1128/MCB.26.3.965-975.2006
10.1074/jbc.M105044200
10.1046/j.1432-1327.2000.01346.x
10.1046/j.1365-2443.1996.d01-261.x
10.1128/JVI.01294-10
10.1046/j.1432-1327.2001.02166.x
10.1128/JVI.01542-10
10.1016/S0042-6822(03)00264-2
10.1128/JVI.02205-08
ContentType Journal Article
Copyright Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology
Copyright_xml – notice: Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7U9
H94
5PM
DOI 10.1128/JVI.01490-13
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AIDS and Cancer Research Abstracts
Virology and AIDS Abstracts
DatabaseTitleList MEDLINE - Academic
AIDS and Cancer Research Abstracts
MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 11935
ExternalDocumentID PMC3807344
23966399
10_1128_JVI_01490_13
jvi_87_21_11930
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-~X
.55
.GJ
0R~
18M
29L
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
6TJ
85S
AAFWJ
AAGFI
AAYJJ
AAYXX
ABPPZ
ACGFO
ACNCT
ADBBV
ADXHL
AENEX
AFFNX
AGVNZ
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CITATION
CS3
D0S
DIK
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HYE
HZ~
IH2
KQ8
MVM
N9A
O9-
OHT
OK1
P2P
RHI
RNS
RPM
RSF
TR2
UPT
VH1
W2D
W8F
WH7
WOQ
X7M
Y6R
YQT
ZGI
ZXP
~02
~KM
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7U9
H94
5PM
ID FETCH-LOGICAL-c511t-184cffbb6e6ff7a8aa468bf077f0859bad4697c1c57026983276fbcc7cf8e52e3
ISSN 0022-538X
1098-5514
IngestDate Thu Aug 21 14:07:41 EDT 2025
Fri Jul 11 15:39:58 EDT 2025
Fri Jul 11 15:12:33 EDT 2025
Thu Apr 03 07:08:17 EDT 2025
Thu Apr 24 23:05:20 EDT 2025
Tue Jul 01 01:02:26 EDT 2025
Wed May 18 15:26:14 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 21
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c511t-184cffbb6e6ff7a8aa468bf077f0859bad4697c1c57026983276fbcc7cf8e52e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
M. Abe and M. Tahara contributed equally to this work.
OpenAccessLink https://jvi.asm.org/content/jvi/87/21/11930.full.pdf
PMID 23966399
PQID 1443405530
PQPubID 23479
PageCount 6
ParticipantIDs proquest_miscellaneous_1664194581
crossref_citationtrail_10_1128_JVI_01490_13
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3807344
pubmed_primary_23966399
proquest_miscellaneous_1443405530
highwire_asm_jvi_87_21_11930
crossref_primary_10_1128_JVI_01490_13
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-11-01
PublicationDateYYYYMMDD 2013-11-01
PublicationDate_xml – month: 11
  year: 2013
  text: 2013-11-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 1752 N St., N.W., Washington, DC
PublicationTitle Journal of Virology
PublicationTitleAlternate J Virol
PublicationYear 2013
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References e_1_3_2_26_2
e_1_3_2_27_2
e_1_3_2_28_2
e_1_3_2_29_2
Karron RA (e_1_3_2_15_2) 2007
Kido H (e_1_3_2_2_2) 2008; 3
e_1_3_2_20_2
e_1_3_2_21_2
e_1_3_2_22_2
e_1_3_2_23_2
e_1_3_2_24_2
e_1_3_2_25_2
e_1_3_2_9_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_32_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_14_2
18562527 - J Virol. 2008 Sep;82(17):8942-6
20507279 - Biochem J. 2010 Jun 15;428(3):325-46
21325420 - J Virol. 2011 May;85(9):4122-34
15705970 - Mol Cell Proteomics. 2005 May;4(5):626-36
9707628 - Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10224-8
22811538 - J Virol. 2012 Oct;86(19):10579-86
11060317 - J Biol Chem. 2001 Jan 12;276(2):857-60
4795670 - Virology. 1973 Nov;56(1):172-80
16428450 - Mol Cell Biol. 2006 Feb;26(3):965-75
11358500 - Eur J Biochem. 2001 May;268(10):2847-55
15742319 - Proteomics. 2005 Apr;5(5):1292-8
19565019 - J Mol Genet Med. 2008 Nov 29;3(1):167-75
23468491 - J Virol. 2013 May;87(10):5502-11
20926566 - J Virol. 2010 Dec;84(24):12658-64
19158246 - J Virol. 2009 Apr;83(7):3200-11
10824103 - Eur J Biochem. 2000 Jun;267(11):3189-97
16973594 - J Virol. 2006 Oct;80(19):9896-8
19581128 - Trends Mol Med. 2009 Jul;15(7):303-12
18448517 - J Virol. 2008 Jul;82(14):6820-8
9367367 - J Gen Virol. 1997 Nov;78 ( Pt 11):2813-20
23365447 - J Virol. 2013 Apr;87(8):4237-51
22496216 - J Virol. 2012 Jun;86(12):6537-45
21068237 - J Virol. 2011 Jan;85(2):873-82
20631123 - J Virol. 2010 Oct;84(19):10016-25
12951033 - Virology. 2003 Aug 15;313(1):198-212
21994442 - J Virol. 2011 Dec;85(24):13363-72
11756432 - J Biol Chem. 2002 Mar 8;277(10):8338-45
20237084 - J Virol. 2010 Jun;84(11):5605-14
21123387 - J Virol. 2011 Feb;85(4):1554-62
1618859 - J Biol Chem. 1992 Jul 5;267(19):13573-9
9078386 - Genes Cells. 1996 Jun;1(6):569-79
1331518 - J Virol. 1992 Dec;66(12):7211-6
References_xml – ident: e_1_3_2_19_2
  doi: 10.1074/mcp.M500004-MCP200
– ident: e_1_3_2_26_2
  doi: 10.1128/jvi.66.12.7211-7216.1992
– ident: e_1_3_2_28_2
  doi: 10.1073/pnas.95.17.10224
– ident: e_1_3_2_18_2
  doi: 10.1128/JVI.00140-10
– ident: e_1_3_2_29_2
  doi: 10.1016/0042-6822(73)90296-1
– ident: e_1_3_2_3_2
  doi: 10.1016/j.molmed.2009.05.003
– ident: e_1_3_2_32_2
  doi: 10.1042/BJ20100046
– ident: e_1_3_2_11_2
  doi: 10.1128/JVI.02062-10
– ident: e_1_3_2_8_2
  doi: 10.1128/JVI.00676-08
– ident: e_1_3_2_5_2
  doi: 10.1128/JVI.01118-06
– ident: e_1_3_2_31_2
  doi: 10.1074/jbc.R000020200
– ident: e_1_3_2_9_2
  doi: 10.1128/JVI.05300-11
– ident: e_1_3_2_30_2
  doi: 10.1128/JVI.00246-08
– start-page: 1497
  volume-title: Fields virology
  year: 2007
  ident: e_1_3_2_15_2
– ident: e_1_3_2_10_2
  doi: 10.1128/JVI.02232-10
– ident: e_1_3_2_6_2
  doi: 10.1128/JVI.00306-12
– ident: e_1_3_2_13_2
  doi: 10.1128/JVI.00094-12
– ident: e_1_3_2_23_2
  doi: 10.1128/JVI.00239-10
– ident: e_1_3_2_20_2
  doi: 10.1002/pmic.200401011
– ident: e_1_3_2_7_2
  doi: 10.1128/JVI.03005-12
– ident: e_1_3_2_25_2
  doi: 10.1016/S0021-9258(18)42250-8
– volume: 3
  start-page: 167
  year: 2008
  ident: e_1_3_2_2_2
  article-title: Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses
  publication-title: J. Mol. Genet. Med.
– ident: e_1_3_2_17_2
  doi: 10.1099/0022-1317-78-11-2813
– ident: e_1_3_2_14_2
  doi: 10.1128/JVI.00128-13
– ident: e_1_3_2_34_2
  doi: 10.1128/MCB.26.3.965-975.2006
– ident: e_1_3_2_33_2
  doi: 10.1074/jbc.M105044200
– ident: e_1_3_2_27_2
  doi: 10.1046/j.1432-1327.2000.01346.x
– ident: e_1_3_2_16_2
  doi: 10.1046/j.1365-2443.1996.d01-261.x
– ident: e_1_3_2_22_2
  doi: 10.1128/JVI.01294-10
– ident: e_1_3_2_24_2
  doi: 10.1046/j.1432-1327.2001.02166.x
– ident: e_1_3_2_12_2
  doi: 10.1128/JVI.01542-10
– ident: e_1_3_2_21_2
  doi: 10.1016/S0042-6822(03)00264-2
– ident: e_1_3_2_4_2
  doi: 10.1128/JVI.02205-08
– reference: 20926566 - J Virol. 2010 Dec;84(24):12658-64
– reference: 19565019 - J Mol Genet Med. 2008 Nov 29;3(1):167-75
– reference: 23468491 - J Virol. 2013 May;87(10):5502-11
– reference: 11756432 - J Biol Chem. 2002 Mar 8;277(10):8338-45
– reference: 1331518 - J Virol. 1992 Dec;66(12):7211-6
– reference: 11060317 - J Biol Chem. 2001 Jan 12;276(2):857-60
– reference: 18448517 - J Virol. 2008 Jul;82(14):6820-8
– reference: 10824103 - Eur J Biochem. 2000 Jun;267(11):3189-97
– reference: 22496216 - J Virol. 2012 Jun;86(12):6537-45
– reference: 21325420 - J Virol. 2011 May;85(9):4122-34
– reference: 21994442 - J Virol. 2011 Dec;85(24):13363-72
– reference: 21123387 - J Virol. 2011 Feb;85(4):1554-62
– reference: 21068237 - J Virol. 2011 Jan;85(2):873-82
– reference: 16973594 - J Virol. 2006 Oct;80(19):9896-8
– reference: 23365447 - J Virol. 2013 Apr;87(8):4237-51
– reference: 11358500 - Eur J Biochem. 2001 May;268(10):2847-55
– reference: 9707628 - Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10224-8
– reference: 15705970 - Mol Cell Proteomics. 2005 May;4(5):626-36
– reference: 20507279 - Biochem J. 2010 Jun 15;428(3):325-46
– reference: 9367367 - J Gen Virol. 1997 Nov;78 ( Pt 11):2813-20
– reference: 18562527 - J Virol. 2008 Sep;82(17):8942-6
– reference: 20631123 - J Virol. 2010 Oct;84(19):10016-25
– reference: 20237084 - J Virol. 2010 Jun;84(11):5605-14
– reference: 16428450 - Mol Cell Biol. 2006 Feb;26(3):965-75
– reference: 12951033 - Virology. 2003 Aug 15;313(1):198-212
– reference: 4795670 - Virology. 1973 Nov;56(1):172-80
– reference: 19158246 - J Virol. 2009 Apr;83(7):3200-11
– reference: 19581128 - Trends Mol Med. 2009 Jul;15(7):303-12
– reference: 15742319 - Proteomics. 2005 Apr;5(5):1292-8
– reference: 22811538 - J Virol. 2012 Oct;86(19):10579-86
– reference: 1618859 - J Biol Chem. 1992 Jul 5;267(19):13573-9
– reference: 9078386 - Genes Cells. 1996 Jun;1(6):569-79
SSID ssj0014464
Score 2.349923
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion...
SourceID pubmedcentral
proquest
pubmed
crossref
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 11930
SubjectTerms Animals
Cell Line
Epithelial Cells - virology
Host-Pathogen Interactions
Humans
Paramyxovirinae - physiology
Sendai virus
Serine Endopeptidases - metabolism
Viral Load
Viral Plaque Assay
Virus Replication
Virus-Cell Interactions
Title TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses
URI http://jvi.asm.org/content/87/21/11930.abstract
https://www.ncbi.nlm.nih.gov/pubmed/23966399
https://www.proquest.com/docview/1443405530
https://www.proquest.com/docview/1664194581
https://pubmed.ncbi.nlm.nih.gov/PMC3807344
Volume 87
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELdgCIkXxDeFgYIET1VGPpw4eazQPjpto1q7qW_W2Y1HNpqitUVifz13cZKmUNDgJUqvlhv5rnf3c3y_Y-w9gp50gpHS9bjyXJ763E3BpK4IUQhamQiowPn4JD4444fjaLxqb1VWlyzUjr7ZWFfyP1pFGeqVqmT_QbPNpCjAe9QvXlHDeL2djo8Hp8Nh0O0T0XK3p22rMsT-A2JfwPhUHiI8bb1NHwC1hCj7ktxA9zy_Xs6rQ4S_J6hUAdfec-8pu4sNc7iarRA_MT5beV404iFcVX2uZ8vLvHEtMIUL6r5SBjycfpq3dx38sCq_a3lSArFh2RYY44h1nsRNShlY27tW4dRakS2Grnylj7mj1wq89Dna7NUDqlQ4PO_vEKDzXFu9uk6effJZ7p0dHcnR7nh0l90LEDWQn94fNyd-CPnymjyeHr2ugwiSj-251zOUmjV6EwL59SBtKzMZPWIPK405PWsfj9mdrHjC7tsmoz-esv3KSpz-3IHCWVmJU1uJg1bitKzEWbMSp7KSZ-xsb3f06cCt2me4GrPohYvYXRujVJzFxghIAHicKOMJYYjVTsGEx6nQvo4EAvEUXbuIjdJaaJNkUZCFz9lWMSuyl8whFJ4BCDCTFG-V8kBNkkliUg6Y4nsd1q2XTOqKW55anHyVJcYMEokLLMsFln7YYR-a0d8sp8ofxm3Xqy9hPpWX33OZCBn4sjSdDntXa0SiT6QXXVBks-Uc4SwPEYhEfx0Tx9xPeZT4HfbCarF5mCBMY8rcO0ys6bcZQJzs698U-ZeSm536N4Scv7rF775mD1b_rG22tbheZm8ww12ot6Xd_gTVDaYF
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=TMPRSS2+Is+an+Activating+Protease+for+Respiratory+Parainfluenza+Viruses&rft.jtitle=Journal+of+virology&rft.au=Abe%2C+Masako&rft.au=Tahara%2C+Maino&rft.au=Sakai%2C+Kouji&rft.au=Yamaguchi%2C+Hiromi&rft.date=2013-11-01&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=87&rft.issue=21&rft.spage=11930&rft.epage=11935&rft_id=info:doi/10.1128%2FJVI.01490-13&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon