A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine

• Published in: Scientific reports Vol. 10; no. 1; p. 4205
• Main Authors: Kvetkina, Aleksandra, Leychenko, Elena, Chausova, Victoria, Zelepuga, Elena, Chernysheva, Nadezhda, Guzev, Konstantin, Pislyagin, Evgeny, Yurchenko, Ekaterina, Menchinskaya, Ekaterina, Aminin, Dmitry, Kaluzhskiy, Leonid, Ivanov, Alexis, Peigneur, Steve, Tytgat, Jan, Kozlovskaya, Emma, Isaeva, Marina
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.03.2020; Nature Publishing Group
• Subjects: 6-Hydroxydopamine; 631/45; 631/45/611; Amino Acid Sequence; Animals; Cell Survival - genetics; Cell Survival - physiology; Cell viability; Endopeptidases; Exons - genetics; Female; Heteractis crispa; Humanities and Social Sciences; Inflammation; Introns; Isoforms; multidisciplinary; Neuroblastoma; Neuroprotection; Neurotoxicity; Peptides; Peptides - chemistry; Peptides - genetics; Peptides - metabolism; Phylogeny; Protein Binding - genetics; Protein Binding - physiology; Protein Isoforms - genetics; Protein Isoforms - metabolism; Science; Science (multidisciplinary); Sea Anemones - genetics; Sea Anemones - metabolism; Serine; Serine Proteases - genetics; Serine Proteases - metabolism; Thermodynamics; Trypsin

The Kunitz/BPTI-type peptides are ubiquitous in numerous organisms including marine venomous animals. The peptides demonstrate various biological activities and therefore they are the subject of a number of investigations. We have discovered a new HCIQ subfamily belonging to recently described multi...