A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine - Kvetkina, Aleksandra; Leychenko, Elena; Chausova, Victoria; Zelepuga, Elena; Chernysheva, Nadezhda; Guzev, Konstantin; Pislyagin, Evgeny; Yurchenko, Ekaterina; Menchinskaya, Ekaterina; Aminin, Dmitry; Kaluzhskiy, Leonid; Ivanov, Alexis; et al. (Scientific reports, 2020)
Keywords: 6-Hydroxydopamine; 631/45; 631/45/611; Amino Acid Sequence; Animals; Cell Survival - genetics; Cell Survival - physiology; Cell viability; Endopeptidases; Exons - genetics; Female; Heteractis crispa; Humanities and Social Sciences; Inflammation; Introns; Isoforms; multidisciplinary; Neuroblastoma; Neuroprotection; Neurotoxicity; Peptides; Peptides - chemistry; Peptides - genetics; Peptides - metabolism; Phylogeny; Protein Binding - genetics; Protein Binding - physiology; Protein Isoforms - genetics; Protein Isoforms - metabolism; Science; Science (multidisciplinary); Sea Anemones - genetics; Sea Anemones - metabolism; Serine; Serine Proteases - genetics; Serine Proteases - metabolism; Thermodynamics; Trypsin