The etiology of preeclampsia

• Published in: American journal of obstetrics and gynecology Vol. 226; no. 2; pp. S844 - S866
• Main Authors: Jung, Eunjung, Romero, Roberto, Yeo, Lami, Gomez-Lopez, Nardhy, Chaemsaithong, Piya, Jaovisidha, Adithep, Gotsch, Francesca, Erez, Offer
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022
• Subjects: angiotensin receptor II; atherosclerosis; autoantibodies; Ballantyne syndrome; body mass index; COVID-19; Cushing’s syndrome; endothelial cell dysfunction; Female; genetic incompatibility; gestational diabetes mellitus; Humans; hydatidiform mole; hydrops fetalis; hyperaldosteronism; hyperparathyroidism; hypertension; infection; inflammation; insulin resistance; intestinal dysbiosis; maternal antifetal rejection; metabolic syndrome; mirror syndrome; molar pregnancy; obesity; placental aging; placental ischemia; placental lesions of maternal vascular malperfusion; Pre-Eclampsia - etiology; Pre-Eclampsia - physiopathology; Pregnancy; primipaternity; proteinuria; SARS-CoV-2; sleep disorders; sleep-disordered breathing; snoring; tolerance; angiotensin receptor II; infection; proteinuria; intestinal dysbiosis; Cushing’s syndrome; hyperparathyroidism; primipaternity; placental ischemia; COVID-19; SARS-CoV-2; sleep-disordered breathing; inflammation; Ballantyne syndrome; snoring; mirror syndrome; placental aging; autoantibodies; insulin resistance; obesity; tolerance; atherosclerosis; sleep disorders; body mass index; hydatidiform mole; hydrops fetalis; gestational diabetes mellitus; endothelial cell dysfunction; metabolic syndrome; placental lesions of maternal vascular malperfusion; maternal antifetal rejection; molar pregnancy; hyperaldosteronism; genetic incompatibility; hypertension

Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes overlapping pathologic processes activate a common pathway consisting of endothelial cell activation, intravascular inflammation, and syncytiotrophoblast stress. This article reviews the potential etiologies of...