Emerging role of microglia in the developing dopaminergic system: Perturbation by early life stress

• Published in: Neural regeneration research Vol. 21; no. 1; pp. 126 - 140
• Main Authors: She, Kaijie, Yuan, Naijun, Huang, Minyi, Zhu, Wenjun, Tang, Manshi, Ma, Qingyu, Chen, Jiaxu
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.01.2026; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: chinese herbal drugs; Dopamine; early life stress; epigenetics; Gut-brain axis; hypothalamo–pituitary–adrenal axis; innate immune memory; microglia; neuroinflammation; parkinson disease; phagocytosis; Review; reward; reward; phagocytosis; neuroinflammation; innate immune memory; Parkinson disease; Chinese herbal drugs; dopamine; hypothalamo-pituitary-adrenal axis; microglia; early life stress; epigenetics; gut-brain axis; hypothalamo–pituitary–adrenal axis

Early life stress correlates with a higher prevalence of neurological disorders, including autism, attention-deficit/hyperactivity disorder, schizophrenia, depression, and Parkinson's disease. These conditions, primarily involving abnormal development and damage of the dopaminergic system, pose...