A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition

• Published in: Clinical pharmacology and therapeutics Vol. 93; no. 6; p. 493
• Main Authors: Theunissen, E L, Street, D, Højer, A-M, Vermeeren, A, van Oers, A, Ramaekers, J G
• Format: Journal Article
• Language: English
• Published: United States 01.06.2013
• Subjects: Adult; Antidepressive Agents - adverse effects; Antidepressive Agents - pharmacokinetics; Antidepressive Agents - pharmacology; Automobile Driving; Cognition - drug effects; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Mianserin - adverse effects; Mianserin - analogs & derivatives; Mianserin - pharmacokinetics; Mianserin - pharmacology; Piperazines - adverse effects; Piperazines - pharmacokinetics; Piperazines - pharmacology; Psychomotor Performance - drug effects; Sulfides - adverse effects; Sulfides - pharmacokinetics; Sulfides - pharmacology

The aim of this study was to assess the effects of a novel antidepressant, vortioxetine 10 mg, on driving, cognitive, and psychomotor performance in 24 healthy subjects in a double-blind, placebo-controlled, three-way crossover design. Mirtazapine 30 mg was included as an active comparator. Drugs we...