Hydroxytyrosol isolation, comparison of synthetic routes and potential biological activities

Hydroxytyrosol (HT) is a polyphenol found in the olive plant (Olea europaea) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h th...

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Published inFood science & nutrition Vol. 12; no. 10; pp. 6899 - 6912
Main Authors Wang, Enhui, Jiang, Yanfei, Zhao, Chunyue
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.10.2024
John Wiley and Sons Inc
Subjects
Antiviral drugs
Apoptosis
biocatalysis
Biological activity
Biological effects
Biological properties
Cancer
Catalysis
Cell cycle
Chemical synthesis
Chromatography
Cytokines
Dietary supplements
Energy consumption
Enzymes
Food industry
Food plants
Fruits
Gram-positive bacteria
hydroxytyrosol
Natural resources
Neuroprotection
Olive oil
Olives
Oxidation
Pharmaceutical industry
Phenols
physical extraction
Raw materials
Review
Solvent extraction processes
Transcription factors
Wound healing
chemical synthesis
biological activity
hydroxytyrosol
physical extraction
biocatalysis
Online AccessGet full text
ISSN2048-7177
2048-7177
DOI10.1002/fsn3.4349

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Abstract Hydroxytyrosol (HT) is a polyphenol found in the olive plant (Olea europaea) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h through chemical synthesis and 7.7 g/L/h through biocatalysis; however, both methods are subject to inherent limitations. Furthermore, the potential health benefits associated with HT have been highlighted, including its ability to act as an antioxidant, reduce inflammation, combat cancer and obesity, and exert antibacterial and antiviral effects. Its neuroprotective effects, skin protection, and wound healing capabilities are also discussed. Given these remarkable biological properties, HT stands out as one of the most extensively investigated natural phenols. This review highlights future methods and pathways for the synthesis of HT, providing insights based on its bioactivity characteristics, health benefits, and potential future applications. Hydroxytyrosol (HT) is a polyphenol extracted from olive plant and its byproduct. This review highlights methods and pathways for the synthesis of hydroxytyrosol, providing insights based on its bioactivity characteristics, health benefits, and potential future applications.
AbstractList Hydroxytyrosol (HT) is a polyphenol found in the olive plant (Olea europaea) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h through chemical synthesis and 7.7 g/L/h through biocatalysis; however, both methods are subject to inherent limitations. Furthermore, the potential health benefits associated with HT have been highlighted, including its ability to act as an antioxidant, reduce inflammation, combat cancer and obesity, and exert antibacterial and antiviral effects. Its neuroprotective effects, skin protection, and wound healing capabilities are also discussed. Given these remarkable biological properties, HT stands out as one of the most extensively investigated natural phenols. This review highlights future methods and pathways for the synthesis of HT, providing insights based on its bioactivity characteristics, health benefits, and potential future applications.Hydroxytyrosol (HT) is a polyphenol found in the olive plant (Olea europaea) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h through chemical synthesis and 7.7 g/L/h through biocatalysis; however, both methods are subject to inherent limitations. Furthermore, the potential health benefits associated with HT have been highlighted, including its ability to act as an antioxidant, reduce inflammation, combat cancer and obesity, and exert antibacterial and antiviral effects. Its neuroprotective effects, skin protection, and wound healing capabilities are also discussed. Given these remarkable biological properties, HT stands out as one of the most extensively investigated natural phenols. This review highlights future methods and pathways for the synthesis of HT, providing insights based on its bioactivity characteristics, health benefits, and potential future applications.
Hydroxytyrosol (HT) is a polyphenol found in the olive plant ( ) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h through chemical synthesis and 7.7 g/L/h through biocatalysis; however, both methods are subject to inherent limitations. Furthermore, the potential health benefits associated with HT have been highlighted, including its ability to act as an antioxidant, reduce inflammation, combat cancer and obesity, and exert antibacterial and antiviral effects. Its neuroprotective effects, skin protection, and wound healing capabilities are also discussed. Given these remarkable biological properties, HT stands out as one of the most extensively investigated natural phenols. This review highlights future methods and pathways for the synthesis of HT, providing insights based on its bioactivity characteristics, health benefits, and potential future applications.
Hydroxytyrosol (HT) is a polyphenol found in the olive plant ( Olea europaea ) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h through chemical synthesis and 7.7 g/L/h through biocatalysis; however, both methods are subject to inherent limitations. Furthermore, the potential health benefits associated with HT have been highlighted, including its ability to act as an antioxidant, reduce inflammation, combat cancer and obesity, and exert antibacterial and antiviral effects. Its neuroprotective effects, skin protection, and wound healing capabilities are also discussed. Given these remarkable biological properties, HT stands out as one of the most extensively investigated natural phenols. This review highlights future methods and pathways for the synthesis of HT, providing insights based on its bioactivity characteristics, health benefits, and potential future applications.
Hydroxytyrosol (HT) is a polyphenol found in the olive plant ( Olea europaea ) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h through chemical synthesis and 7.7 g/L/h through biocatalysis; however, both methods are subject to inherent limitations. Furthermore, the potential health benefits associated with HT have been highlighted, including its ability to act as an antioxidant, reduce inflammation, combat cancer and obesity, and exert antibacterial and antiviral effects. Its neuroprotective effects, skin protection, and wound healing capabilities are also discussed. Given these remarkable biological properties, HT stands out as one of the most extensively investigated natural phenols. This review highlights future methods and pathways for the synthesis of HT, providing insights based on its bioactivity characteristics, health benefits, and potential future applications. Hydroxytyrosol (HT) is a polyphenol extracted from olive plant and its byproduct. This review highlights methods and pathways for the synthesis of hydroxytyrosol, providing insights based on its bioactivity characteristics, health benefits, and potential future applications.
Hydroxytyrosol (HT) is a polyphenol found in the olive plant (Olea europaea) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT has evolved from basic separation and extraction to chemical and biocatalytic synthesis. The yield of HT can reach 1.93 g/L/h through chemical synthesis and 7.7 g/L/h through biocatalysis; however, both methods are subject to inherent limitations. Furthermore, the potential health benefits associated with HT have been highlighted, including its ability to act as an antioxidant, reduce inflammation, combat cancer and obesity, and exert antibacterial and antiviral effects. Its neuroprotective effects, skin protection, and wound healing capabilities are also discussed. Given these remarkable biological properties, HT stands out as one of the most extensively investigated natural phenols. This review highlights future methods and pathways for the synthesis of HT, providing insights based on its bioactivity characteristics, health benefits, and potential future applications. Hydroxytyrosol (HT) is a polyphenol extracted from olive plant and its byproduct. This review highlights methods and pathways for the synthesis of hydroxytyrosol, providing insights based on its bioactivity characteristics, health benefits, and potential future applications.
Author Zhao, Chunyue
Wang, Enhui
Jiang, Yanfei
AuthorAffiliation 1 Beijing Qingyan Boshi Health Management Co., Ltd Beijing China
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  email: zhaochunyue@mail.fivedoctors.cn
  organization: Beijing Qingyan Boshi Health Management Co., Ltd
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39479663$$D View this record in MEDLINE/PubMed
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Keywords chemical synthesis
biological activity
hydroxytyrosol
physical extraction
biocatalysis
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Snippet Hydroxytyrosol (HT) is a polyphenol found in the olive plant (Olea europaea) that has garnered attention from the food, feed, supplement, and pharmaceutical...
Hydroxytyrosol (HT) is a polyphenol found in the olive plant ( Olea europaea ) that has garnered attention from the food, feed, supplement, and pharmaceutical...
Hydroxytyrosol (HT) is a polyphenol found in the olive plant ( ) that has garnered attention from the food, feed, supplement, and pharmaceutical industries. HT...
Hydroxytyrosol (HT) is a polyphenol found in the olive plant ( Olea europaea ) that has garnered attention from the food, feed, supplement, and pharmaceutical...
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SubjectTerms Antiviral drugs
Apoptosis
biocatalysis
Biological activity
Biological effects
Biological properties
Cancer
Catalysis
Cell cycle
Chemical synthesis
Chromatography
Cytokines
Dietary supplements
Energy consumption
Enzymes
Food industry
Food plants
Fruits
Gram-positive bacteria
hydroxytyrosol
Natural resources
Neuroprotection
Olive oil
Olives
Oxidation
Pharmaceutical industry
Phenols
physical extraction
Raw materials
Review
Solvent extraction processes
Transcription factors
Wound healing
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Title Hydroxytyrosol isolation, comparison of synthetic routes and potential biological activities
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Ffsn3.4349
https://www.ncbi.nlm.nih.gov/pubmed/39479663
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https://pubmed.ncbi.nlm.nih.gov/PMC11521723
Volume 12
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