Mapping neurotransmitter networks with PET: An example on serotonin and opioid systems

• Published in: Human brain mapping Vol. 35; no. 5; pp. 1875 - 1884
• Main Authors: Tuominen, Lauri, Nummenmaa, Lauri, Keltikangas-Järvinen, Liisa, Raitakari, Olli, Hietala, Jarmo
• Format: Journal Article
• Language: English
• Published: New York, NY Blackwell Publishing Ltd 01.05.2014; Wiley-Liss; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adult; Benzylamines - pharmacokinetics; Biological and medical sciences; Brain - anatomy & histology; Brain - diagnostic imaging; Brain - metabolism; Brain Mapping; connectivity; correlation; Female; Fentanyl - analogs & derivatives; Fentanyl - pharmacokinetics; Humans; Image Processing, Computer-Assisted; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nervous system; Neurotransmitter Agents - metabolism; Positron-Emission Tomography; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radionuclide investigations; Receptors, Opioid, mu - metabolism; Serotonin - metabolism; serotonin transporter; μ-opioid receptor; Cartography; Nervous system diseases; Radiodiagnosis; Serotonin; μ Opioid receptor; μ-opioid receptor; connectivity; correlation; serotonin transporter; Neuromediator; Neurotransmitter; Positron emission tomography; Emission tomography; positron emission tomography

All functions of the human brain are consequences of altered activity of specific neural pathways and neurotransmitter systems. Although the knowledge of “system level” connectivity in the brain is increasing rapidly, we lack “molecular level” information on brain networks and connectivity patterns....