Wnt signals are transmitted through N-terminally dephosphorylated β-catenin

• Published in: EMBO reports Vol. 3; no. 1; pp. 63 - 68
• Main Authors: Staal, Frank J T, van Noort, Mascha, Strous, Ger J, Clevers, Hans C
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.2002; Oxford University Press
• Subjects: Animals; beta Catenin; Calpain - antagonists & inhibitors; CHO Cells; Cricetinae; Cytoskeletal Proteins - physiology; DNA-Binding Proteins - physiology; Leupeptins - pharmacology; Lymphoid Enhancer-Binding Factor 1; Phosphorylation; Proto-Oncogene Proteins - physiology; Scientific Reports; Signal Transduction; Trans-Activators - physiology; Transcription Factors - physiology; Transcription, Genetic - physiology; Wnt Proteins; Zebrafish Proteins

β‐catenin mediates Wnt signaling by acting as the essential co‐activator for TCF transcription factors. Wnt signaling increases the half‐life and therefore the absolute level of β‐catenin in responding cells. The current model states that these changes in β‐catenin stability set the threshold for Wn...