Total Serum Bilirubin Predicts Fat‐Soluble Vitamin Deficiency Better Than Serum Bile Acids in Infants With Biliary Atresia

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 59; no. 6; pp. 702 - 707
• Main Authors: Venkat, Veena L., Shneider, Benjamin L., Magee, John C., Turmelle, Yumirle, Arnon, Ronen, Bezerra, Jorge A., Hertel, Paula M., Karpen, Saul J., Kerkar, Nanda, Loomes, Kathleen M., Molleston, Jean, Murray, Karen F., Ng, Vicky L., Raghunathan, Trivellore, Rosenthal, Philip, Schwartz, Kathleen, Sherker, Averell H., Sokol, Ronald J., Teckman, Jeffrey, Wang, Kasper, Whitington, Peter F., Heubi, James E.
• Format: Journal Article
• Language: English
• Published: United States by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology 01.12.2014
• Subjects: Avitaminosis - blood; Avitaminosis - etiology; Bile Acids and Salts - blood; biliary atresia; Biliary Atresia - blood; Biliary Atresia - complications; bilirubin; Bilirubin - blood; cholestasis; Dietary Supplements; Double-Blind Method; fat‐soluble vitamin; Female; Humans; Infant; Infant, Newborn; Male; National Institute of Diabetes and Digestive and Kidney Diseases (U.S.); Placebos; Prospective Studies; serum bile acid; United States; Vitamin A - administration & dosage; Vitamin A - blood; Vitamin D - administration & dosage; Vitamin D - blood; Vitamin E - administration & dosage; Vitamin E - blood; Vitamin K - administration & dosage; Vitamin K - blood; Vitamins - administration & dosage; United States

ABSTRACT Objective: Fat‐soluble vitamin (FSV) deficiency is a well‐recognized consequence of cholestatic liver disease and reduced intestinal intraluminal bile acid. We hypothesized that serum bile acid (SBA) would predict biochemical FSV deficiency better than serum total bilirubin (TB) level in in...