Increased opioid consumption in neoadjuvant immunotherapy plus chemotherapy for patients with non‐small‐cell lung cancer: A multicenter, prospective cohort study

• Published in: CNS neuroscience & therapeutics Vol. 30; no. 8; pp. e14893 - n/a
• Main Authors: Wang, Kaiyuan, Er, Jianxu, Zhang, Yu, Song, Chengcheng, Yu, Yang, Gao, Ruifang, Xu, Hong, Dong, Xiaolin, Yuan, Limei, Liu, Qiangwei, Han, Jiange, Yu, Yonghao, Yin, Yiqing
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2024; John Wiley and Sons Inc
• Subjects: Adult; Aged; analgesia; Analgesics; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - therapeutic use; Anesthesia; Body mass index; Cancer therapies; Carcinoma, Non-Small-Cell Lung - surgery; Chemotherapy; Cognitive ability; Cohort analysis; Cohort Studies; Delirium; Female; Humans; Immunotherapy; Immunotherapy - methods; Lung cancer; Lung Neoplasms; Male; Medical prognosis; Middle Aged; Morphine; Narcotics; neoadjuvant immunotherapy; Neoadjuvant Therapy; Non-small cell lung carcinoma; non‐small‐cell lung cancer; opioid consumption; Opioids; Original; Pain; Pain perception; Pain, Postoperative; Patients; PD-L1 protein; postoperative delirium; postoperative pain; Prospective Studies; Regression analysis; Statistical analysis; Sufentanil; Surgery; non‐small‐cell lung cancer; opioid consumption; postoperative delirium; neoadjuvant immunotherapy; postoperative pain; analgesia

Aims PD‐1 block was reported to impair opioid‐induced antinociception and affect cognitive function in rodents and non‐human primates. This prospective multicenter cohort study aims to investigate the possible impact of neoadjuvant immunotherapy with PD‐1 antibody on perioperative analgesic effect o...