Inhibition of cobalamin‐dependent methionine synthase by substituted benzo‐fused heterocycles - Banks, Elizabeth C.; Doughty, Stephen W.; Toms, Steven M.; Wheelhouse, Richard T.; Nicolaou, Anna (The FEBS journal, 2007)
Keywords: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - antagonists & inhibitors; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - chemistry; Amino Acid Sequence; Animals; benzimidazole; Benzimidazoles - chemical synthesis; Benzimidazoles - pharmacology; benzothiadiazole; Binding Sites; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Enzymes; Hydrogen Bonding; Hydrogen bonds; inhibition; Inhibitor drugs; Kinetics; Liver; Liver - enzymology; methionine synthase; Models, Molecular; molecular modelling; Molecular Sequence Data; Molecular structure; Pharmacology; Rats; Rodents; Sequence Homology; Signal transduction; Structure-Activity Relationship; Tetrahydrofolates - chemistry; Tetrahydrofolates - metabolism; Thiadiazoles - chemistry; Thiadiazoles - pharmacology