Dose Optimization of Vancomycin Using a Mechanism-based Exposure–Response Model in Pediatric Infectious Disease Patients

• Published in: Clinical therapeutics Vol. 43; no. 1; pp. 185 - 194.e16
• Main Authors: Jung, Woo Jin, Park, Jung-Hyuck, Goo, Sungwoo, Chae, Jung-woo, Kim, JaeWoo, Shin, Sooyoung, Yun, Hwi-yeol
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; Elsevier Limited
• Subjects: Age; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Bacteria; Body Size; C-reactive protein; C-Reactive Protein - analysis; Child; Communicable Diseases - blood; Communicable Diseases - drug therapy; Communicable Diseases - metabolism; Creatinine; Dosage; dose optimization; Dose-Response Relationship, Drug; Electronic medical records; Female; Gram-positive bacteria; Humans; Infectious diseases; Internal Medicine; Kidneys; Male; mechanism-based PK/PD model; Microbial Sensitivity Tests; Minimum inhibitory concentration; Models, Biological; Optimization; Parameter estimation; Patients; Pediatrics; Pharmacodynamics; Pharmacokinetics; Premature birth; Proteins; Simulation; Software; Staphylococcus infections; Vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics; vancomycin; dose optimization; mechanism-based PK/PD model; pediatrics

This study aimed to determine the appropriate vancomycin dosage, considering patient size and organ maturation, by simulating the bacterial count and biomarker level for drug administration in pediatric patients with gram-positive bacterial (GPB) infections. Natural language processing for n-gram an...