Dose Optimization of Vancomycin Using a Mechanism-based Exposure–Response Model in Pediatric Infectious Disease Patients - Jung, Woo Jin; Park, Jung-Hyuck; Goo, Sungwoo; Chae, Jung-woo; Kim, JaeWoo; Shin, Sooyoung; Yun, Hwi-yeol (Clinical therapeutics, 2021)
Keywords: Age; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Bacteria; Body Size; C-reactive protein; C-Reactive Protein - analysis; Child; Communicable Diseases - blood; Communicable Diseases - drug therapy; Communicable Diseases - metabolism; Creatinine; Dosage; dose optimization; Dose-Response Relationship, Drug; Electronic medical records; Female; Gram-positive bacteria; Humans; Infectious diseases; Internal Medicine; Kidneys; Male; mechanism-based PK/PD model; Microbial Sensitivity Tests; Minimum inhibitory concentration; Models, Biological; Optimization; Parameter estimation; Patients; Pediatrics; Pharmacodynamics; Pharmacokinetics; Premature birth; Proteins; Simulation; Software; Staphylococcus infections; Vancomycin; Vancomycin - administration & dosage; Vancomycin - pharmacokinetics; vancomycin; dose optimization; mechanism-based PK/PD model; pediatrics