Construction of YAC-based mammalian artificial chromosomes

To construct a mammalian artificial chromosome (MAC), telomere repeats and selectable markers were introduced into a 100 kb yeast artificial chromosome (YAC) containing human centromeric DNA. This YAC, which has a regular repeat structure of alpha-satellite DNA and centromere protein B (CENP-B) boxe...

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Published in	Nature biotechnology Vol. 16; no. 5; pp. 431 - 439
Main Authors	Ikeno, Masashi, Grimes, Brenda, Okazaki, Tuneko, Nakano, Megumi, Saitoh, Kaori, Hoshino, Harumi, McGill, Niolette I, Cooke, Howard, Masumoto, Hiroshi
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.05.1998 Nature
Subjects	Agriculture Animals Autoantigens Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell Line Cell Line, Transformed Centromere - genetics Centromere Protein B Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - genetics Chromosomes - genetics Chromosomes, Artificial, Yeast - genetics Chromosomes, Human, Pair 21 - genetics Cloning, Molecular DNA, Satellite - chemistry DNA, Satellite - genetics DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics Genetic Vectors - genetics Humans In Situ Hybridization, Fluorescence Kinetochores Life Sciences Methods. Procedures. Technologies Polymerase Chain Reaction research-article Telomere - genetics Transfection Vectors (cloning, transfer, expression). Insertion sequences and transposons Human Alpha satellite DNA Vertebrata Cell line Mammalia Artificial chromosome Vector Structural analysis Genetic transfer
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Abstract	To construct a mammalian artificial chromosome (MAC), telomere repeats and selectable markers were introduced into a 100 kb yeast artificial chromosome (YAC) containing human centromeric DNA. This YAC, which has a regular repeat structure of alpha-satellite DNA and centromere protein B (CENP-B) boxes, efficiently formed MACs that segregated accurately and bound CENP-B, CENP-C, and CENP-E. The MACs appear to be about 1–5 Mb in size and contain YAC multimers. Structural analyses suggest that the MACs have not acquired host sequences and were formed by a de novo mechanism. The accurate segregation of the MACs suggests they have potential as vectors for introducing genes into mammals.
AbstractList	To construct a mammalian artificial chromosome (MAC), telomere repeats and selectable markers were introduced into a 100 kb yeast artificial chromosome (YAC) containing human centromeric DNA. This YAC, which has a regular repeat structure of alpha-satellite DNA and centromere protein B (CENP-B) boxes, efficiently formed MACs that segregated accurately and bound CENP-B, CENP-C, and CENP-E. The MACs appear to be about 1-5 Mb in size and contain YAC multimers. Structural analyses suggest that the MACs have not acquired host sequences and were formed by a de novo mechanism. The accurate segregation of the MACs suggests they have potential as vectors for introducing genes into mammals.
Author	Okazaki, Tuneko Grimes, Brenda Masumoto, Hiroshi Nakano, Megumi Saitoh, Kaori Ikeno, Masashi Cooke, Howard Hoshino, Harumi McGill, Niolette I
Author_xml	– sequence: 1 givenname: Masashi surname: Ikeno fullname: Ikeno, Masashi – sequence: 2 givenname: Brenda surname: Grimes fullname: Grimes, Brenda – sequence: 3 givenname: Tuneko surname: Okazaki fullname: Okazaki, Tuneko – sequence: 4 givenname: Megumi surname: Nakano fullname: Nakano, Megumi – sequence: 5 givenname: Kaori surname: Saitoh fullname: Saitoh, Kaori – sequence: 6 givenname: Harumi surname: Hoshino fullname: Hoshino, Harumi – sequence: 7 givenname: Niolette I surname: McGill fullname: McGill, Niolette I – sequence: 8 givenname: Howard surname: Cooke fullname: Cooke, Howard – sequence: 9 givenname: Hiroshi surname: Masumoto fullname: Masumoto, Hiroshi
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Snippet	To construct a mammalian artificial chromosome (MAC), telomere repeats and selectable markers were introduced into a 100 kb yeast artificial chromosome (YAC)...
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SubjectTerms	Agriculture Animals Autoantigens Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell Line Cell Line, Transformed Centromere - genetics Centromere Protein B Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - genetics Chromosomes - genetics Chromosomes, Artificial, Yeast - genetics Chromosomes, Human, Pair 21 - genetics Cloning, Molecular DNA, Satellite - chemistry DNA, Satellite - genetics DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics Genetic Vectors - genetics Humans In Situ Hybridization, Fluorescence Kinetochores Life Sciences Methods. Procedures. Technologies Polymerase Chain Reaction research-article Telomere - genetics Transfection Vectors (cloning, transfer, expression). Insertion sequences and transposons
Title	Construction of YAC-based mammalian artificial chromosomes
URI	http://dx.doi.org/10.1038/nbt0598-431 https://link.springer.com/article/10.1038/nbt0598-431 https://www.ncbi.nlm.nih.gov/pubmed/9592390 https://search.proquest.com/docview/16447664 https://search.proquest.com/docview/79867895
Volume	16
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