Monitoring colorectal cancer following surgery using plasma circulating tumor DNA

• Published in: Oncology letters Vol. 15; no. 4; pp. 4365 - 4375
• Main Authors: Sun, Xiao, Huang, Tanxiao, Cheng, Fangsheng, Huang, Kaibing, Liu, Ming, He, Wan, Li, Mingwei, Zhang, Xiaoni, Xu, Mingyan, Chen, Shifu, Xia, Ligang
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.04.2018; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Antigens; Cancer cells; Cancer therapies; Care and treatment; Chemotherapy; Colorectal cancer; Deoxyribonucleic acid; Diagnosis; DNA; Ethics; Genetic aspects; Health aspects; Library collections; Medical prognosis; Methods; Mutation; Plasma; Postoperative care; Prognosis; Surgery; Tumor markers; China; United States > US; colorectal cancer; postoperative monitoring; next generation sequencing; liquid biopsy; circulating tumor DNA

Postoperative monitoring for patients with colorectal cancer (CRC) requires sensitive biomarkers that are associated with medical response and adjuvant therapy following surgery. Conventional tumor biomarkers [including carcinoembryonic antigen (CEA), CA19-9 and CA125] are widely used, but none of t...