Photo-Induced, Phenylhydrazine-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 19; p. 6915
• Main Authors: Zhu, Yiwei, Wu, Zhimin, Sun, Hongcai, Ding, Junjun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2023; MDPI
• Subjects: aryl halides; Chlorides; Chromatography; Communication; Dichloropropane; Electrolysis; Experiments; Fluorides; Heterocyclic compounds; Hydrazine; Hydrogenation; Light; NMR; Nuclear magnetic resonance; photo-induced hydrogenation; Pressure vessels; radical-mediated hydrogenation; Solvents

In this study, we present a straightforward and highly effective photo-triggered hydrogenation method for aryl halides, devoid of transition-metal catalysts. Through the synergistic utilization of light, PhNHNH2, and a base, we have successfully initiated the desired radical-mediated hydrogenation p...