Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

• Published in: American journal of obstetrics and gynecology Vol. 215; no. 1; pp. S1 - S46
• Main Authors: Ilekis, John V., PhD, Tsilou, Ekaterini, MD, Fisher, Susan, PhD, Abrahams, Vikki M., PhD, Soares, Michael J., PhD, Cross, James C., PhD, Zamudio, Stacy, PhD, Illsley, Nicholas P., DPhil, Myatt, Leslie, PhD, Colvis, Christine, PhD, Costantine, Maged M., MD, Haas, David M., MD, Sadovsky, Yoel, MD, Weiner, Carl, MD, Rytting, Erik, PhD, Bidwell, Gene, PhD
• Format: Journal Article Conference Proceeding
• Language: English
• Published: United States Elsevier Inc 01.07.2016
• Subjects: Animals; Biomarkers - metabolism; Drug Delivery Systems; Drug Discovery; drugs; Female; Genetic Markers; Humans; Mice; Models, Animal; Molecular Targeted Therapy; National Institute of Child Health and Human Development (U.S.); Obstetrics and Gynecology; placenta; Placenta - embryology; Placenta - immunology; Placenta - metabolism; Placenta - physiopathology; Placenta Diseases - drug therapy; Placenta Diseases - genetics; Placenta Diseases - metabolism; Placenta Diseases - physiopathology; Pregnancy; Pregnancy Outcome; Rats; therapeutics; Translational Medical Research; trial; United States; placenta; therapeutics; drugs; trial; pregnancy

Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related disorders, a significant gap exists in the utilization of this information for the development of new drug therapies to improve pregnancy outcome...