Longitudinal changes in airway remodeling and air trapping in severe asthma

• Published in: Academic radiology Vol. 21; no. 8; p. 986
• Main Authors: Witt, Chad A, Sheshadri, Ajay, Carlstrom, Luke, Tarsi, Jaime, Kozlowski, James, Wilson, Brad, Gierada, David S, Hoffman, Eric, Fain, Sean B, Cook-Granroth, Janice, Sajol, Geneline, Sierra, Oscar, Giri, Tusar, O'Neill, Michael, Zheng, Jie, Schechtman, Kenneth B, Bacharier, Leonard B, Jarjour, Nizar, Busse, William, Castro, Mario
• Format: Journal Article
• Language: English
• Published: United States 01.08.2014
• Subjects: Adult; Airway Remodeling; Asthma - complications; Asthma - diagnostic imaging; Bronchial Diseases - complications; Bronchial Diseases - diagnostic imaging; Female; Humans; Longitudinal Studies; Lung - diagnostic imaging; Lung - physiopathology; Male; Multidetector Computed Tomography - methods; Reproducibility of Results; Sensitivity and Specificity; computed tomography; airway remodeling; Severe asthma

Previous cross-sectional studies have demonstrated that airway wall thickness and air trapping are greater in subjects with severe asthma than in those with mild-to-moderate asthma. However, a better understanding of how airway remodeling and lung density change over time is needed. This study aimed...