Effect of folic acid on thymidylate synthase and thymidine kinase in regenerating rat liver after partial hepatectomy

• Published in: Biochimica et Biophysica Acta (BBA) - General Subjects Vol. 1379; no. 2; pp. 289 - 296
• Main Authors: Komatsu, Masami, Tsukamoto, Ikuyo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 02.02.1998; Elsevier BV
• Subjects: Animals; Chymotrypsin; Chymotrypsin - metabolism; DNA; DNA - metabolism; DNA synthesis; drug effects; Folic Acid; Folic Acid - pharmacology; genetics; Hepatectomy; Liver Regeneration; Liver Regeneration - drug effects; Liver Regeneration - genetics; Liver Regeneration - physiology; Male; messenger RNA; metabolism; Organ Size; Organ Size - drug effects; pharmacology; physiology; Proteins; Proteins - metabolism; Rat; Rats; Rats, Wistar; RNA; RNA - metabolism; RNA, Messenger; RNA, Messenger - genetics; RNA, Messenger - metabolism; Thymidine Kinase; Thymidine Kinase - genetics; Thymidine Kinase - metabolism; Thymidylate Synthase; Thymidylate Synthase - genetics; Thymidylate Synthase - metabolism; Thymidine kinase; Rat; Dig, digoxigenin; TK, thymidine kinase; PH, partial (70%) hepatectomy; DNA synthesis; TS, thymidylate synthase; Thymidylate synthase; Folic acid; Liver regeneration

The effects of folic acid on liver regeneration after partial hepatectomy were investigated. The injection of folic acid inhibited the increases in the activities of thymidylate synthase and thymidine kinase in regenerating rat liver at 24 h after partial hepatectomy, with a concomitant reduction in...