Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma

Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scans enable a multifaceted analysis of glioma biology, supporting clini...

Full description

Saved in:
Bibliographic Details
Published inNuclear medicine and molecular imaging Vol. 58; no. 4; pp. 237 - 245
Main Authors Kim, Dongwoo, Lee, Suk-Hyun, Hwang, Hee Sung, Kim, Sun Jung, Yun, Mijin
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.06.2024
Springer Nature B.V
대한핵의학회
Subjects
Online AccessGet full text
ISSN1869-3474
1869-3482
DOI10.1007/s13139-024-00847-4

Cover

Abstract Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scans enable a multifaceted analysis of glioma biology, supporting clinical applications from grading and differential diagnosis to mapping the full extent of tumors and planning subsequent treatments and evaluations. With a broad array of specialized radiotracers, researchers and clinicians can now probe various biological characteristics of gliomas, such as glucose utilization, cellular proliferation, oxygen deficiency, amino acid trafficking, and reactive astrogliosis. This review aims to provide a recent update on the application of versatile PET/CT radiotracers in glioma research and clinical practice.
AbstractList Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scans enable a multifaceted analysis of glioma biology, supporting clinical applications from grading and differential diagnosis to mapping the full extent of tumors and planning subsequent treatments and evaluations. With a broad array of specialized radiotracers, researchers and clinicians can now probe various biological characteristics of gliomas, such as glucose utilization, cellular proliferation, oxygen deficiency, amino acid trafficking, and reactive astrogliosis. This review aims to provide a recent update on the application of versatile PET/CT radiotracers in glioma research and clinical practice.
Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scans enable a multifaceted analysis of glioma biology, supporting clinical applications from grading and differential diagnosis to mapping the full extent of tumors and planning subsequent treatments and evaluations. With a broad array of specialized radiotracers, researchers and clinicians can now probe various biological characteristics of gliomas, such as glucose utilization, cellular proliferation, oxygen deficiency, amino acid trafficking, and reactive astrogliosis. This review aims to provide a recent update on the application of versatile PET/CT radiotracers in glioma research and clinical practice.Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scans enable a multifaceted analysis of glioma biology, supporting clinical applications from grading and differential diagnosis to mapping the full extent of tumors and planning subsequent treatments and evaluations. With a broad array of specialized radiotracers, researchers and clinicians can now probe various biological characteristics of gliomas, such as glucose utilization, cellular proliferation, oxygen deficiency, amino acid trafficking, and reactive astrogliosis. This review aims to provide a recent update on the application of versatile PET/CT radiotracers in glioma research and clinical practice.
Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive gliomaevaluation, offering complementary insights to those gained through magnetic resonance imaging (MRI). PET/CT scansenable a multifaceted analysis of glioma biology, supporting clinical applications from grading and differential diagnosisto mapping the full extent of tumors and planning subsequent treatments and evaluations. With a broad array of specializedradiotracers, researchers and clinicians can now probe various biological characteristics of gliomas, such as glucose utilization,cellular proliferation, oxygen deficiency, amino acid trafficking, and reactive astrogliosis. This review aims to providea recent update on the application of versatile PET/CT radiotracers in glioma research and clinical practice. KCI Citation Count: 9
Author Kim, Sun Jung
Yun, Mijin
Hwang, Hee Sung
Kim, Dongwoo
Lee, Suk-Hyun
Author_xml – sequence: 1
  givenname: Dongwoo
  surname: Kim
  fullname: Kim, Dongwoo
  organization: Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
– sequence: 2
  givenname: Suk-Hyun
  surname: Lee
  fullname: Lee, Suk-Hyun
  organization: Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine
– sequence: 3
  givenname: Hee Sung
  surname: Hwang
  fullname: Hwang, Hee Sung
  organization: Department of Nuclear Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine
– sequence: 4
  givenname: Sun Jung
  surname: Kim
  fullname: Kim, Sun Jung
  organization: Department of Nuclear Medicine, National Health Insurance Service Ilsan Hospital
– sequence: 5
  givenname: Mijin
  surname: Yun
  fullname: Yun, Mijin
  email: yunmijin@yuhs.ac
  organization: Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38932755$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003107671$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNp9kUtr3DAUhUVJaR7NH-iiGLopATe6eljSqglDmg4EWobJWsi2PFViS1PJU-i_rzxO0jaLaCOBvnN0rs4xOvDBW4TeAf4EGIvzBBSoKjFhJcaSiZK9QkcgK1VSJsnB01mwQ3Sa0h3OixKFqXiDDqlUlAjOj9DFyjbWj8XttjWjLYIvvl-tzxfrYmVaF8ZoGhtT0YVYLAezcX5TLGy0dTR9cd27MJi36HVn-mRPH_YTdPvlar34Wt58u14uLm_KhgMey1oyK1VDJKlEQ9oWqo4RxgwnRLWdqjnDXSWUskox23HOAOqqkkSCtFK0hp6gs9nXx07fN04H4_b7Juj7qC9X66UGzKXAQDP8eYa3u3qw7TRhTqy30Q0m_t5L_7_x7kc2-qUBQFUcIDt8fHCI4efOplEPLjW27423YZc0xSJn41hNj314ht6FXfT5MyYKlBQS80y9_zfSU5bHKjIgZ6CJIaVoO9240YwuTAldn4fTU_F6Ll7n4vW-eM2ylDyTPrq_KKKzKGXYb2z8G_sF1R9C5bvy
CitedBy_id crossref_primary_10_1007_s00259_024_06964_8
crossref_primary_10_1007_s13139_024_00865_2
crossref_primary_10_1007_s00259_024_06935_z
Cites_doi 10.1212/WNL.32.12.1323
10.2214/AJR.07.2660
10.1097/MD.0000000000002583
10.1371/journal.pone.0111598
10.1016/0883-2889(86)90079-1
10.1007/s00259-012-2275-9
10.1007/s00259-008-0981-0
10.1093/neuonc/nov189
10.1007/s11307-008-0152-5
10.1089/ars.2013.5378
10.1186/s40824-023-00408-4
10.1002/syn.20899
10.1007/s00259-022-05817-6
10.1016/j.clon.2014.02.002
10.1097/RLU.0000000000002006
10.1007/s00259-005-0047-5
10.1016/0020-708X(82)90003-5
10.3390/ijms22115518
10.1016/S0303-8467(01)00197-4
10.1038/bjc.1981.79
10.1097/RLU.0b013e3181becfe0
10.1016/S0360-3016(00)01482-6
10.1093/brain/awad037
10.2967/jnumed.107.046615
10.1093/neuonc/nos259
10.1186/s13550-020-00645-x
10.1111/bpa.12307
10.2967/jnumed.111.102533
10.1093/neuonc/nov148
10.1038/jcbfm.2011.84
10.1038/s41593-020-00735-y
10.1016/S0021-9258(19)38247-X
10.5732/cjc.013.10217
10.1007/s00259-021-05603-w
10.3413/Nukmed-0662-14-04
10.2310/7290.2011.00014
10.21037/qims-22-1340
10.1016/S0969-8051(00)00177-3
10.1007/s00401-016-1545-1
10.1111/j.1471-4159.1969.tb06854.x
10.1053/j.semnuclmed.2007.08.001
10.1097/00004647-199805000-00005
10.1007/s00401-008-0455-2
10.1093/neuonc/noad243
10.2967/jnumed.112.104992
10.1007/s00259-018-3948-9
10.1016/j.celrep.2020.107975
10.1371/journal.pone.0095830
10.3389/fneur.2021.740280
10.1046/j.1471-4159.1995.64062773.x
10.1007/s00259-019-04337-0
10.1007/s13139-020-00672-5
10.1016/j.surge.2013.12.001
10.1038/jcbfm.1993.110
10.3390/ijms20194669
10.1016/j.cell.2014.11.025
10.3390/cancers12071977
10.1007/s11060-012-0986-1
10.1038/nm.3639
10.1093/neuonc/noab106
10.1097/RLU.0000000000004341
10.3390/cancers13194777
10.1007/s00259-001-0690-4
10.2967/jnumed.120.249524
10.1016/j.jocn.2009.05.009
10.1126/science.1173362
10.1007/s00259-005-0023-0
10.2967/jnumed.112.105544
10.1177/0271678X20911469
10.1007/s00259-018-4207-9
10.1016/S1474-4422(06)70597-X
10.1523/JNEUROSCI.18-14-05225.1998
10.1056/NEJM197204272861707
10.3390/jcm8081088
10.1259/bjr.20170426
10.1111/j.1471-4159.2004.02935.x
10.3389/fneur.2021.671867
10.2967/jnumed.112.112201
10.1093/neuonc/noac040
10.1016/j.nucmedbio.2007.11.004
10.1016/S0891-5849(02)00815-8
10.1007/s00259-012-2295-5
10.3390/ijms23126787
10.1007/s00259-003-1404-x
ContentType Journal Article
Copyright The Author(s) 2024. corrected publication 2024
The Author(s), under exclusive licence to Korean Society of Nuclear Medicine 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
The Author(s) 2024. corrected publication 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2024, corrected publication 2024 2024
Copyright_xml – notice: The Author(s) 2024. corrected publication 2024
– notice: The Author(s), under exclusive licence to Korean Society of Nuclear Medicine 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
– notice: The Author(s) 2024. corrected publication 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2024, corrected publication 2024 2024
DBID C6C
AAYXX
CITATION
NPM
NAPCQ
7X8
5PM
ACYCR
DOI 10.1007/s13139-024-00847-4
DatabaseName Springer Nature OA Free Journals
CrossRef
PubMed
Nursing & Allied Health Premium
MEDLINE - Academic
PubMed Central (Full Participant titles)
Korean Citation Index
DatabaseTitle CrossRef
PubMed
Nursing & Allied Health Premium
MEDLINE - Academic
DatabaseTitleList PubMed
Nursing & Allied Health Premium

CrossRef
MEDLINE - Academic


Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1869-3482
EndPage 245
ExternalDocumentID oai_kci_go_kr_ARTI_10587013
PMC11196511
38932755
10_1007_s13139_024_00847_4
Genre Journal Article
Review
GroupedDBID ---
-EM
.UV
06D
0R~
0VY
1N0
203
29~
2KG
2VQ
30V
4.4
406
408
40D
67Z
8JR
96X
9ZL
AAAVM
AACDK
AAHNG
AAIAL
AAJBT
AAJKR
AANXM
AANZL
AARHV
AARTL
AASML
AATNV
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
AAZMS
ABAKF
ABDZT
ABECU
ABFTV
ABJNI
ABJOX
ABKCH
ABMQK
ABPLI
ABQBU
ABSXP
ABTEG
ABTKH
ABTMW
ABXPI
ACAOD
ACDTI
ACGFS
ACHSB
ACHVE
ACKNC
ACMDZ
ACMLO
ACOKC
ACPIV
ACZOJ
ADBBV
ADHHG
ADHIR
ADINQ
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADZKW
AEBTG
AEFQL
AEGNC
AEJHL
AEJRE
AEMSY
AEOHA
AEPYU
AESKC
AETCA
AEVLU
AEXYK
AFBBN
AFLOW
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHSBF
AHYZX
AIAKS
AIGIU
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALFXC
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMXSW
AMYLF
AMYQR
ANMIH
AOCGG
AOIJS
ASPBG
AVWKF
AXYYD
AZFZN
BAWUL
BGNMA
C6C
CSCUP
DDRTE
DIK
DNIVK
DPUIP
EBLON
EBS
EF.
EIOEI
EJD
ESBYG
F5P
FEDTE
FERAY
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FYJPI
GGCAI
GGRSB
GJIRD
GQ6
GQ7
H13
HF~
HMJXF
HRMNR
HVGLF
HYE
HZ~
I0C
IKXTQ
IWAJR
IXD
J-C
J0Z
JBSCW
JZLTJ
KOV
LLZTM
M4Y
NPVJJ
NQJWS
NU0
O9-
O9J
OK1
P9S
PT4
R9I
RLLFE
ROL
RPM
RSV
S27
S37
S3B
SHX
SISQX
SJYHP
SMD
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SZ9
T13
TSG
U2A
U9L
UG4
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W48
WK8
Z45
ZMTXR
ZOVNA
~A9
AAPKM
AAYXX
ABBRH
ABDBE
ABFSG
ACSTC
AEZWR
AFDZB
AFHIU
AFOHR
AHPBZ
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
ABRTQ
NPM
NAPCQ
7X8
5PM
ACYCR
ID FETCH-LOGICAL-c510t-b84e89c28267c2dd16f4244a5229df9b540f6799e994ef55411b6682818e87da3
IEDL.DBID AGYKE
ISSN 1869-3474
IngestDate Sat Sep 06 06:29:09 EDT 2025
Thu Aug 21 18:34:50 EDT 2025
Fri Jul 11 15:26:28 EDT 2025
Wed Sep 03 00:18:58 EDT 2025
Mon Jul 21 06:02:39 EDT 2025
Thu Apr 24 22:53:17 EDT 2025
Tue Jul 01 01:05:52 EDT 2025
Fri Feb 21 02:39:55 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords C-acetate
F-FLT
Amino acid radiotracer
F-FMISO
Glioma
F-FDG
18F-FLT
11C-acetate
18F-FDG
18F-FMISO
Language English
License The Author(s), under exclusive licence to Korean Society of Nuclear Medicine 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c510t-b84e89c28267c2dd16f4244a5229df9b540f6799e994ef55411b6682818e87da3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://proxy.k.utb.cz/login?url=https://link.springer.com/10.1007/s13139-024-00847-4
PMID 38932755
PQID 3071987805
PQPubID 2044329
PageCount 9
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_10587013
pubmedcentral_primary_oai_pubmedcentral_nih_gov_11196511
proquest_miscellaneous_3072815093
proquest_journals_3071987805
pubmed_primary_38932755
crossref_citationtrail_10_1007_s13139_024_00847_4
crossref_primary_10_1007_s13139_024_00847_4
springer_journals_10_1007_s13139_024_00847_4
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-06-01
PublicationDateYYYYMMDD 2024-06-01
PublicationDate_xml – month: 06
  year: 2024
  text: 2024-06-01
  day: 01
PublicationDecade 2020
PublicationPlace Singapore
PublicationPlace_xml – name: Singapore
– name: Germany
– name: Heidelberg
PublicationTitle Nuclear medicine and molecular imaging
PublicationTitleAbbrev Nucl Med Mol Imaging
PublicationTitleAlternate Nucl Med Mol Imaging
PublicationYear 2024
Publisher Springer Nature Singapore
Springer Nature B.V
대한핵의학회
Publisher_xml – name: Springer Nature Singapore
– name: Springer Nature B.V
– name: 대한핵의학회
References CuiMZorrilla-VelozRIHuJGuanBMaXDiagnostic accuracy of PET for differentiating true glioma progression from post treatment-related changes: a systematic review and meta-analysisFront Neurol20211234093419817315710.3389/fneur.2021.671867
IsselbacherKJSugar and amino acid transport by cells in culture–differences between normal and malignant cellsN Engl J Med19722869299331:STN:280:DyaE387ktVCitw%3D%3D433531710.1056/NEJM197204272861707
ChungJKKimYKKimSKLeeYJPaekSYeoJSUsefulness of 11C-methionine PET in the evaluation of brain lesions that are hypo- or isometabolic on 18F-FDG PETEur J Nucl Med Mol Imaging2002291761821:CAS:528:DC%2BD38XnvFSmtg%3D%3D1192637910.1007/s00259-001-0690-4
NicklasWJClarkeDDDecarboxylation studies of glutamate, glutamine, and aspartate from brain labelled with [1-14C]acetate, L-[U-14C]-aspartate, and L-[U-14C]glutamateJ Neurochem1969165495581:CAS:528:DyaF1MXktVWgtb0%3D576821110.1111/j.1471-4159.1969.tb06854.x
WaniewskiRAMartinDLPreferential utilization of acetate by astrocytes is attributable to transportJ Neurosci199818522552331:CAS:528:DyaK1cXksFarsbY%3D9651205679349010.1523/JNEUROSCI.18-14-05225.1998
Mattoli MV, Trevisi G, Scolozzi V, Capotosti A, Cocciolillo F, Marini I, et al. Dynamic (11)C-methionine PET-CT: prognostic factors for disease progression and survival in patients with suspected glioma recurrence. Cancers (Basel). 2021;13:4777.
OmuroAMLeiteCCMokhtariKDelattreJYPitfalls in the diagnosis of brain tumoursLancet Neurol200659379481705266110.1016/S1474-4422(06)70597-X
TakataKKatoHShimosegawaEOkunoTKodaTSugimotoT11C-Acetate PET imaging in patients with multiple sclerosisPLoS ONE2014925369426421972510.1371/journal.pone.0111598
TsuchidaTTakeuchiHOkazawaHTsujikawaTFujibayashiYGrading of brain glioma with 1–11C-acetate PET: comparison with 18F-FDG PETNucl Med Biol2008351711761:CAS:528:DC%2BD1cXhsl2hurw%3D1831282610.1016/j.nucmedbio.2007.11.004
NinattiGSolliniMBonoBGozziNFedorovDAntunovicLPreoperative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomasNeuro Oncol202224154615561:CAS:528:DC%2BB3sXlsVGrtr4%3D35171292943550410.1093/neuonc/noac040
EidelbergDTakikawaSDhawanVChalyTRobesonWDahlRStriatal 18F-dopa uptake: absence of an aging effectJ Cereb Blood Flow Metab1993138818881:CAS:528:DyaK2cXhtVSkurs%3D836029410.1038/jcbfm.1993.110
YoulandRSKitangeGJPetersonTEPafundiDHRamiscalJAPokornyJLThe role of LAT1 in (18)F-DOPA uptake in malignant gliomasJ Neurooncol201311111181:CAS:528:DC%2BC38XhvFSgtLjP2308643110.1007/s11060-012-0986-1
ChenJRYaoYXuHZQinZYIsocitrate dehydrogenase (IDH)1/2 mutations as prognostic markers in patients with glioblastomasMedicine (Baltimore)2016951:CAS:528:DC%2BC28XktVOiu78%3D2694534910.1097/MD.0000000000002583
MiyagawaTOkuTUeharaHDesaiRBeattieBTjuvajevJ“Facilitated” amino acid transport is upregulated in brain tumorsJ Cereb Blood Flow Metab1998185005091:CAS:528:DyaK1cXjsVWitrg%3D959184210.1097/00004647-199805000-00005
Reuss AM, Groos D, Buchfelder M, Savaskan N. The acidic brain-glycolytic switch in the microenvironment of malignant glioma. Int J Mol Sci. 2021;22:5518.
GlaudemansAWEntingRHHeestersMADierckxRAvan RheenenRWWalenkampAMValue of 11C-methionine PET in imaging brain tumours and metastasesEur J Nucl Med Mol Imaging2013406156351:CAS:528:DC%2BC3sXjslOgsbs%3D2323250510.1007/s00259-012-2295-5
DiepYNParkHJKwonJHTranMKoHYJoHAstrocytic scar restricting glioblastoma via glutamate-MAO-B activity in glioblastoma-microglia assembloidBiomater Res202327711:CAS:528:DC%2BB3sXhsFKqu7rJ374689611035502910.1186/s40824-023-00408-4
BrownJMTherapeutic targets in radiotherapyInt J Radiat Oncol Biol Phys2001493193261:STN:280:DC%2BD3M7kvFGlsw%3D%3D1117312410.1016/S0360-3016(00)01482-6
MasuiKCaveneeWKMischelPSmTORC2 and metabolic reprogramming in GBM: at the interface of genetics and environmentBrain Pathol2015257557591:CAS:528:DC%2BC2MXhvVSlsLbM26526943463601610.1111/bpa.12307
WesterHJHerzMWeberWHeissPSenekowitsch-SchmidtkeRSchwaigerMSynthesis and radiopharmacology of O-(2-[18F]fluoroethyl)-L-tyrosine for tumor imagingJ Nucl Med1999402052121:CAS:528:DyaK1MXos1aitA%3D%3D9935078
VesselleHGriersonJMuziMPugsleyJMSchmidtRARabinowitzPIn vivo validation of 3′deoxy-3′-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumorsClin Cancer Res20028331533231:CAS:528:DC%2BD38XpsVCgtr0%3D12429617
GalldiksNKrachtLWDunklVUllrichRTVollmarSJacobsAHImaging of non- or very subtle contrast-enhancing malignant gliomas with [(1)(1)C]-methionine positron emission tomographyMol Imaging2011104534591:CAS:528:DC%2BC38XitlGnsrg%3D2220153610.2310/7290.2011.00014
NagashimaGSuzukiRAsaiJFujimotoTImmunohistochemical analysis of reactive astrocytes around glioblastoma: an immunohistochemical study of postmortem glioblastoma casesClin Neurol Neurosurg20021041251311193204210.1016/S0303-8467(01)00197-4
OuyangZQZhengGRDuanXRZhangXRKeTFBaoSSDiagnostic accuracy of glioma pseudoprogression identification with positron emission tomography imaging: a systematic review and meta-analysisQuant Imaging Med Surg20231349434959375810481042338210.21037/qims-22-1340
Di ChiroGDeLaPazRLBrooksRASokoloffLKornblithPLSmithBHGlucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomographyNeurology19823213231329698304410.1212/WNL.32.12.1323
MashimoTPichumaniKVemireddyVHatanpaaKJSinghDKSirasanagandlaSAcetate is a bioenergetic substrate for human glioblastoma and brain metastasesCell2014159160316141:CAS:528:DC%2BC2MXnslKqug%3D%3D25525878437460210.1016/j.cell.2014.11.025
DhermainFRadiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approachesChin J Cancer20143316241:CAS:528:DC%2BC2cXhsFakurnE24384237390508610.5732/cjc.013.10217
HoCLYuSCYeungDW11C-Acetate PET imaging in hepatocellular carcinoma and other liver massesJ Nucl Med20034421322112571212
Hirata K, Yamaguchi S, Shiga T, Kuge Y, Tamaki N. The roles of hypoxia imaging using (18)F-fluoromisonidazole positron emission tomography in glioma treatment. J Clin Med. 2019;8:1088.
ColletSGuillamoJSBerroDHChakhoyanAConstansJMLechapt-ZalcmanESimultaneous mapping of vasculature, hypoxia, and proliferation using dynamic susceptibility contrast MRI, (18)F-FMISO PET, and (18)F-FLT PET in relation to contrast enhancement in newly diagnosed glioblastomaJ Nucl Med202162134913561:CAS:528:DC%2BB3MXisFamurfE34016725872490310.2967/jnumed.120.249524
JagerPLVaalburgWPruimJde VriesEGLangenKJPiersDARadiolabeled amino acids: basic aspects and clinical applications in oncologyJ Nucl Med2001424324451:CAS:528:DC%2BD3MXmvFOqt7k%3D11337520
TripathiMSharmaRD'SouzaMJaiminiAPanwarPVarshneyRComparative evaluation of F-18 FDOPA, F-18 FDG, and F-18 FLT-PET/CT for metabolic imaging of low grade gliomasClin Nucl Med2009348788832013982110.1097/RLU.0b013e3181becfe0
SmithTAThe rate-limiting step for tumor [18F]fluoro-2-deoxy-D-glucose (FDG) incorporationNucl Med Biol200128141:CAS:528:DC%2BD3MXht1yjs7s%3D1118255810.1016/S0969-8051(00)00177-3
StoberBTanaseUHerzMSeidlCSchwaigerMSenekowitsch-SchmidtkeRDifferentiation of tumour and inflammation: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cellsEur J Nucl Med Mol Imaging2006339329391660434610.1007/s00259-005-0047-5
DunetVPomoniAHottingerANicod-LalondeMPriorJOPerformance of 18F-FET versus 18F-FDG-PET for the diagnosis and grading of brain tumors: systematic review and meta-analysisNeuro Oncol2016184264341:CAS:528:DC%2BC1cXptVKntg%3D%3D2624379110.1093/neuonc/nov148
HasselBSonnewaldUFonnumFGlial-neuronal interactions as studied by cerebral metabolism of [2-13C]acetate and [1-13C]glucose: an ex vivo 13C NMR spectroscopic studyJ Neurochem199564277327821:CAS:528:DyaK2MXlsl2lt7s%3D776005810.1046/j.1471-4159.1995.64062773.x
BarajasRFJrPampaloniMHClarkeJLSeoYSavicDHawkinsRAAssessing biological response to bevacizumab using 18F-fluoromisonidazole PET/MR imaging in a patient with recurrent anaplastic astrocytomaCase Rep Radiol20152015257931364352456
LouisDNPerryAWesselingPBratDJCreeIAFigarella-BrangerDThe 2021 WHO classification of tumors of the central nervous system: a summaryNeuro Oncol202123123112511:CAS:528:DC%2BB3MXisFSht73J34185076832801310.1093/neuonc/noab106
MatsubaraKWatabeHKumakuraYHayashiTEndresCJMinatoKSensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism: a simulation study for [(1)(8)F]FDOPA PET by a model with detailed dopamine pathwaySynapse2011657517621:CAS:528:DC%2BC3MXmvFWhtrk%3D2119022010.1002/syn.20899
CruzNFLasaterAZielkeHRDienelGAActivation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brainJ Neurochem2005929349471:CAS:528:DC%2BD2MXhs1Kqtbs%3D1568649610.1111/j.1471-4159.2004.02935.x
KatoHOkunoTIsohashiKKodaTShimizuMMochizukiHAstrocyte metabolism in multiple sclerosis investigated by 1-C-11 acetate PETJ Cereb Blood Flow Metab2021413693791:CAS:528:DC%2BB3MXhtlOlu70%3D3216901310.1177/0271678X20911469
SinghalTNarayananTKJacobsMPBalCMantilJC11C-Methionine PET for grading and prognostication in gliomas: a comparison study with 18F-FDG PET and contrast enhancement on MRIJ Nucl Med201253170917152305553410.2967/jnumed.111.102533
KimDChunJHKimSHMoonJHKangSGChangJHRe-evaluation of the diagnostic performance of (11)C-methionine PET/CT according to the 2016 WHO classification of cerebral gliomasEur J Nucl Med Mol Imaging201946167816841:CAS:528:DC%2BC1MXhtFert7vI3110200110.1007/s00259-019-04337-0
LiuRSChangCPChuLSChuYKHsiehHJChangCWPET imaging of brain astrocytoma with 1–11C-acetateEur J Nucl Med Mol Imaging2006334204271640459610.1007/s00259-005-0023-0
HammondEMAsselinMCForsterDO'ConnorJPSenraJMWilliamsKJThe meaning, measurement and modification of hypoxia in the laboratory and the clinicClin Oncol (R Coll Radiol)2014262772881:STN:280
G Nagashima (847_CR63) 2002; 104
847_CR44
EW Lau (847_CR31) 2010; 17
A Salskov (847_CR81) 2007; 37
J Balss (847_CR23) 2008; 116
NL Jansen (847_CR49) 2012; 14
SM Lee (847_CR21) 2002; 32
AM Omuro (847_CR17) 2006; 5
D Kim (847_CR50) 2019; 46
ZQ Ouyang (847_CR11) 2023; 13
JY Heo (847_CR61) 2020; 30
JD Chapman (847_CR93) 1981; 43
JM Johnson (847_CR20) 2021; 12
T Singhal (847_CR4) 2012; 53
847_CR36
A Shinomiya (847_CR86) 2013; 40
B Stober (847_CR42) 2006; 33
AK Demetriades (847_CR18) 2014; 12
H Kato (847_CR66) 2021; 41
H Chun (847_CR60) 2020; 23
E Ferdova (847_CR88) 2015; 35
RF Barajas Jr (847_CR98) 2015; 2015
PJ Pollard (847_CR22) 2009; 324
N Galldiks (847_CR34) 2011; 10
A Falk Delgado (847_CR35) 2018; 91
V Dunet (847_CR43) 2016; 18
YN Diep (847_CR79) 2023; 27
H Barthel (847_CR80) 2003; 63
847_CR1
D Salber (847_CR41) 2007; 48
E Guedj (847_CR14) 2022; 49
T Zaragori (847_CR48) 2020; 10
RA Waniewski (847_CR54) 1998; 18
P Heiss (847_CR39) 1999; 40
PL Jager (847_CR25) 2001; 42
JR Chen (847_CR24) 2016; 95
N Oyama (847_CR67) 2002; 43
MH Nam (847_CR62) 2020; 32
WJ Nicklas (847_CR53) 1969; 16
D Kim (847_CR8) 2018; 43
M Kinoshita (847_CR29) 2012; 53
847_CR5
EM Hammond (847_CR92) 2014; 26
PA Jerabek (847_CR94) 1986; 37
MT Wyss (847_CR56) 2011; 31
JM Brown (847_CR90) 2001; 49
K Matsubara (847_CR45) 2011; 65
I Law (847_CR12) 2019; 46
S Kim (847_CR75) 2018; 45
MR Ponisio (847_CR51) 2020; 7
AK Bag (847_CR37) 2022; 63
DN Louis (847_CR3) 2021; 23
T Mashimo (847_CR70) 2014; 159
S Collet (847_CR96) 2021; 62
G Ninatti (847_CR38) 2022; 24
D Kim (847_CR76) 2020; 54
W Chen (847_CR30) 2006; 47
RS Liu (847_CR72) 2006; 33
847_CR77
Y Yamamoto (847_CR73) 2008; 10
B Hassel (847_CR58) 1995; 64
DN Louis (847_CR2) 2016; 131
G Di Chiro (847_CR15) 1982; 32
M Nowosielski (847_CR87) 2014; 9
JC Walsh (847_CR89) 2014; 21
AW Glaudemans (847_CR33) 2013; 40
RS Youland (847_CR47) 2013; 111
T Miyagawa (847_CR28) 1998; 18
TA Smith (847_CR16) 2001; 28
N Oyama (847_CR68) 2009; 36
M Tripathi (847_CR85) 2009; 34
T Gronroos (847_CR95) 2004; 31
NF Cruz (847_CR55) 2005; 92
D Eidelberg (847_CR46) 1993; 13
S Jo (847_CR59) 2014; 20
K Masui (847_CR71) 2015; 25
MH Nam (847_CR64) 2023; 146
OS Tehrani (847_CR83) 2013; 54
KJ Isselbacher (847_CR26) 1972; 286
K Takata (847_CR65) 2014; 9
HJ Wester (847_CR40) 1999; 40
T Tsuchida (847_CR74) 2008; 35
847_CR19
VW Pike (847_CR52) 1982; 33
D Kim (847_CR78) 2022; 47
847_CR10
847_CR97
A Piccardo (847_CR13) 2022; 49
N Kosaka (847_CR7) 2008; 190
M Cui (847_CR9) 2021; 12
CL Ho (847_CR69) 2003; 44
847_CR91
AJ Idema (847_CR82) 2012; 53
S Cerdan (847_CR57) 1990; 265
JK Chung (847_CR32) 2002; 29
H Busch (847_CR27) 1959; 19
H Vesselle (847_CR84) 2002; 8
F Dhermain (847_CR6) 2014; 33
39881977 - Nucl Med Mol Imaging. 2025 Feb;59(1):91. doi: 10.1007/s13139-024-00879-w
References_xml – reference: WaniewskiRAMartinDLPreferential utilization of acetate by astrocytes is attributable to transportJ Neurosci199818522552331:CAS:528:DyaK1cXksFarsbY%3D9651205679349010.1523/JNEUROSCI.18-14-05225.1998
– reference: KatoHOkunoTIsohashiKKodaTShimizuMMochizukiHAstrocyte metabolism in multiple sclerosis investigated by 1-C-11 acetate PETJ Cereb Blood Flow Metab2021413693791:CAS:528:DC%2BB3MXhtlOlu70%3D3216901310.1177/0271678X20911469
– reference: PollardPJRatcliffePJCancer. Puzzling patterns of predispositionScience20093241921941:CAS:528:DC%2BD1MXkvFyhsrY%3D1935957310.1126/science.1173362
– reference: IsselbacherKJSugar and amino acid transport by cells in culture–differences between normal and malignant cellsN Engl J Med19722869299331:STN:280:DyaE387ktVCitw%3D%3D433531710.1056/NEJM197204272861707
– reference: DunetVPomoniAHottingerANicod-LalondeMPriorJOPerformance of 18F-FET versus 18F-FDG-PET for the diagnosis and grading of brain tumors: systematic review and meta-analysisNeuro Oncol2016184264341:CAS:528:DC%2BC1cXptVKntg%3D%3D2624379110.1093/neuonc/nov148
– reference: ChunHImHKangYJKimYShinJHWonWSevere reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H(2)O(2)(-) productionNat Neurosci202023155515661:CAS:528:DC%2BB3cXitlGjsLrE3319989610.1038/s41593-020-00735-y
– reference: TsuchidaTTakeuchiHOkazawaHTsujikawaTFujibayashiYGrading of brain glioma with 1–11C-acetate PET: comparison with 18F-FDG PETNucl Med Biol2008351711761:CAS:528:DC%2BD1cXhsl2hurw%3D1831282610.1016/j.nucmedbio.2007.11.004
– reference: Mattoli MV, Trevisi G, Scolozzi V, Capotosti A, Cocciolillo F, Marini I, et al. Dynamic (11)C-methionine PET-CT: prognostic factors for disease progression and survival in patients with suspected glioma recurrence. Cancers (Basel). 2021;13:4777.
– reference: Treglia G, Muoio B, Trevisi G, Mattoli MV, Albano D, Bertagna F, et al. Diagnostic performance and prognostic value of PET/CT with different tracers for brain tumors: a systematic review of published meta-analyses. Int J Mol Sci. 2019;20:4669.
– reference: NicklasWJClarkeDDDecarboxylation studies of glutamate, glutamine, and aspartate from brain labelled with [1-14C]acetate, L-[U-14C]-aspartate, and L-[U-14C]glutamateJ Neurochem1969165495581:CAS:528:DyaF1MXktVWgtb0%3D576821110.1111/j.1471-4159.1969.tb06854.x
– reference: IdemaAJHoffmannALBoogaartsHDTroostEGWesselingPHeerschapA3′-Deoxy-3′-18F-fluorothymidine PET-derived proliferative volume predicts overall survival in high-grade glioma patientsJ Nucl Med201253190419101:CAS:528:DC%2BC3sXktFKrug%3D%3D2307711210.2967/jnumed.112.105544
– reference: HasselBSonnewaldUFonnumFGlial-neuronal interactions as studied by cerebral metabolism of [2-13C]acetate and [1-13C]glucose: an ex vivo 13C NMR spectroscopic studyJ Neurochem199564277327821:CAS:528:DyaK2MXlsl2lt7s%3D776005810.1046/j.1471-4159.1995.64062773.x
– reference: HeissPMayerSHerzMWesterHJSchwaigerMSenekowitsch-SchmidtkeRInvestigation of transport mechanism and uptake kinetics of O-(2-[18F]fluoroethyl)-L-tyrosine in vitro and in vivoJ Nucl Med199940136713731:CAS:528:DyaK1MXlslSktrY%3D10450690
– reference: TehraniOSShieldsAFPET imaging of proliferation with pyrimidinesJ Nucl Med2013549039121:CAS:528:DC%2BC3sXpvFeitr8%3D2367457610.2967/jnumed.112.112201
– reference: PonisioMRMcConathyJEDahiyaSMMiller-ThomasMMRichKMSalterADynamic (18)F-FDOPA-PET/MRI for the preoperative evaluation of gliomas: correlation with stereotactic histopathologyNeurooncol Pract20207656667333126797716181
– reference: NamMHChoJKwonDHParkJYWooJLeeJMExcessive astrocytic GABA causes cortical hypometabolism and impedes functional recovery after subcortical strokeCell Rep2020321:CAS:528:DC%2BB3cXhsVyltL%2FE3269800910.1016/j.celrep.2020.107975
– reference: Kim D, Ko HY, Lee S, Lee YH, Ryu S, Kim SY, et al. Glucose loading enhances the value of (18)F-FDG PET/CT for the characterization and delineation of cerebral gliomas. Cancers (Basel). 2020;12:1977.
– reference: JansenNLSchwartzCGrauteVEigenbrodSLutzJEgenspergerRPrediction of oligodendroglial histology and LOH 1p/19q using dynamic [(18)F]FET-PET imaging in intracranial WHO grade II and III gliomasNeuro Oncol201214147314801:CAS:528:DC%2BC38XhslWktL%2FJ23090986349901510.1093/neuonc/nos259
– reference: DiepYNParkHJKwonJHTranMKoHYJoHAstrocytic scar restricting glioblastoma via glutamate-MAO-B activity in glioblastoma-microglia assembloidBiomater Res202327711:CAS:528:DC%2BB3sXhsFKqu7rJ374689611035502910.1186/s40824-023-00408-4
– reference: Heiss WD. PET in gliomas. Overview of current studies. Nuklearmedizin. 2014;53:163–71; quiz N32.
– reference: NinattiGSolliniMBonoBGozziNFedorovDAntunovicLPreoperative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomasNeuro Oncol202224154615561:CAS:528:DC%2BB3sXlsVGrtr4%3D35171292943550410.1093/neuonc/noac040
– reference: CerdanSKunneckeBSeeligJCerebral metabolism of [1,2–13C2]acetate as detected by in vivo and in vitro 13C NMRJ Biol Chem199026512916129261:CAS:528:DyaK3cXkvFGhsbk%3D197393110.1016/S0021-9258(19)38247-X
– reference: CuiMZorrilla-VelozRIHuJGuanBMaXDiagnostic accuracy of PET for differentiating true glioma progression from post treatment-related changes: a systematic review and meta-analysisFront Neurol20211234093419817315710.3389/fneur.2021.671867
– reference: KimDKimSKimSHChangJHYunMPrediction of overall survival based on isocitrate dehydrogenase 1 mutation and 18F-FDG uptake on PET/CT in patients with cerebral gliomasClin Nucl Med2018433113162948545010.1097/RLU.0000000000002006
– reference: DhermainFRadiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approachesChin J Cancer20143316241:CAS:528:DC%2BC2cXhsFakurnE24384237390508610.5732/cjc.013.10217
– reference: BalssJMeyerJMuellerWKorshunovAHartmannCvon DeimlingAAnalysis of the IDH1 codon 132 mutation in brain tumorsActa Neuropathol20081165976021:CAS:528:DC%2BD1cXhtlyhsbfN1898536310.1007/s00401-008-0455-2
– reference: OyamaNOkazawaHKusukawaNKanedaTMiwaYAkinoH11C-Acetate PET imaging for renal cell carcinomaEur J Nucl Med Mol Imaging2009364224271901852910.1007/s00259-008-0981-0
– reference: LeeSMKohHJParkDCSongBJHuhTLParkJWCytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cellsFree Radic Biol Med200232118511961:CAS:528:DC%2BD38XjvVehu7g%3D1203190210.1016/S0891-5849(02)00815-8
– reference: WyssMTMagistrettiPJBuckAWeberBLabeled acetate as a marker of astrocytic metabolismJ Cereb Blood Flow Metab201131166816741:CAS:528:DC%2BC3MXps1Omt7Y%3D21654698317095510.1038/jcbfm.2011.84
– reference: SalskovATammisettiVSGriersonJVesselleHFLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3′-deoxy-3′-[18F]fluorothymidineSemin Nucl Med2007374294391792035010.1053/j.semnuclmed.2007.08.001
– reference: GalldiksNKrachtLWDunklVUllrichRTVollmarSJacobsAHImaging of non- or very subtle contrast-enhancing malignant gliomas with [(1)(1)C]-methionine positron emission tomographyMol Imaging2011104534591:CAS:528:DC%2BC38XitlGnsrg%3D2220153610.2310/7290.2011.00014
– reference: KimDChunJHKimSHMoonJHKangSGChangJHRe-evaluation of the diagnostic performance of (11)C-methionine PET/CT according to the 2016 WHO classification of cerebral gliomasEur J Nucl Med Mol Imaging201946167816841:CAS:528:DC%2BC1MXhtFert7vI3110200110.1007/s00259-019-04337-0
– reference: OuyangZQZhengGRDuanXRZhangXRKeTFBaoSSDiagnostic accuracy of glioma pseudoprogression identification with positron emission tomography imaging: a systematic review and meta-analysisQuant Imaging Med Surg20231349434959375810481042338210.21037/qims-22-1340
– reference: KosakaNTsuchidaTUematsuHKimuraHOkazawaHItohH18F-FDG PET of common enhancing malignant brain tumorsAJR Am J Roentgenol2008190W365W3691849287910.2214/AJR.07.2660
– reference: NagashimaGSuzukiRAsaiJFujimotoTImmunohistochemical analysis of reactive astrocytes around glioblastoma: an immunohistochemical study of postmortem glioblastoma casesClin Neurol Neurosurg20021041251311193204210.1016/S0303-8467(01)00197-4
– reference: Kim D, Ko HY, Chung JI, Park YM, Lee S, Kim SY, et al. Visualizing cancer-originating acetate uptake through MCT1 in reactive astrocytes in the glioblastoma tumor microenvironment. Neuro Oncol. 2023. https://doi.org/10.1093/neuonc/noad243.
– reference: Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008–2012. Neuro Oncol. 2015;17 Suppl 4:iv1-iv62.
– reference: OmuroAMLeiteCCMokhtariKDelattreJYPitfalls in the diagnosis of brain tumoursLancet Neurol200659379481705266110.1016/S1474-4422(06)70597-X
– reference: FerdovaEFerdaJBaxaJTupyRMracekJTopolcanOAssessment of grading in newly-diagnosed glioma using 18F-fluorothymidine PET/CTAnticancer Res2015359559591:CAS:528:DC%2BC2MXlslKrtrk%3D25667480
– reference: KimSKimDKimSHParkMAChangJHYunMThe roles of (11)C-acetate PET/CT in predicting tumor differentiation and survival in patients with cerebral gliomaEur J Nucl Med Mol Imaging201845101210202951183810.1007/s00259-018-3948-9
– reference: NowosielskiMDiFrancoMDPutzerDSeizMRecheisWJacobsAHAn intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomasPLoS ONE2014924759867399748410.1371/journal.pone.0095830
– reference: ChenWSilvermanDHDelaloyeSCzerninJKamdarNPopeW18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracyJ Nucl Med2006479049111:CAS:528:DC%2BD28XmtlWmsbY%3D16741298
– reference: YamamotoYNishiyamaYKimuraNKameyamaRKawaiNHatakeyamaT11C-Acetate PET in the evaluation of brain glioma: comparison with 11C-methionine and 18F-FDG-PETMol Imaging Biol2008102812871:STN:280:DC%2BD1cvpvVygtQ%3D%3D1854304110.1007/s11307-008-0152-5
– reference: LouisDNPerryAReifenbergerGvon DeimlingAFigarella-BrangerDCaveneeWKThe 2016 World Health Organization classification of tumors of the central nervous system: a summaryActa Neuropathol20161318038202715793110.1007/s00401-016-1545-1
– reference: PiccardoAAlbertNLBorgwardtLFaheyFHHargraveDGalldiksNJoint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [(18)F]FDG: version 1.0Eur J Nucl Med Mol Imaging.20224938526935536420939921110.1007/s00259-022-05817-6
– reference: Falk DelgadoAFalkDADiscrimination between primary low-grade and high-grade glioma with (11)C-methionine PET: a bivariate diagnostic test accuracy meta-analysisBr J Radiol2018912017042629206062596577510.1259/bjr.20170426
– reference: TripathiMSharmaRD'SouzaMJaiminiAPanwarPVarshneyRComparative evaluation of F-18 FDOPA, F-18 FDG, and F-18 FLT-PET/CT for metabolic imaging of low grade gliomasClin Nucl Med2009348788832013982110.1097/RLU.0b013e3181becfe0
– reference: GronroosTBentzenLMarjamakiPMurataRHorsmanMRKeidingSComparison of the biodistribution of two hypoxia markers [18F]FETNIM and [18F]FMISO in an experimental mammary carcinomaEur J Nucl Med Mol Imaging2004315135201472267510.1007/s00259-003-1404-x
– reference: ZaragoriTGinetMMariePYRochVGrignonRGauchotteGUse of static and dynamic [(18)F]-F-DOPA PET parameters for detecting patients with glioma recurrence or progressionEJNMMI Res2020105632472232726033110.1186/s13550-020-00645-x
– reference: SmithTAThe rate-limiting step for tumor [18F]fluoro-2-deoxy-D-glucose (FDG) incorporationNucl Med Biol200128141:CAS:528:DC%2BD3MXht1yjs7s%3D1118255810.1016/S0969-8051(00)00177-3
– reference: StoberBTanaseUHerzMSeidlCSchwaigerMSenekowitsch-SchmidtkeRDifferentiation of tumour and inflammation: characterisation of [methyl-3H]methionine (MET) and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cellsEur J Nucl Med Mol Imaging2006339329391660434610.1007/s00259-005-0047-5
– reference: BarthelHCleijMCCollingridgeDRHutchinsonOCOsmanSHeQ3′-Deoxy-3′-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomographyCancer Res200363379137981:CAS:528:DC%2BD3sXltVGqs78%3D12839975
– reference: ColletSGuillamoJSBerroDHChakhoyanAConstansJMLechapt-ZalcmanESimultaneous mapping of vasculature, hypoxia, and proliferation using dynamic susceptibility contrast MRI, (18)F-FMISO PET, and (18)F-FLT PET in relation to contrast enhancement in newly diagnosed glioblastomaJ Nucl Med202162134913561:CAS:528:DC%2BB3MXisFamurfE34016725872490310.2967/jnumed.120.249524
– reference: ChenJRYaoYXuHZQinZYIsocitrate dehydrogenase (IDH)1/2 mutations as prognostic markers in patients with glioblastomasMedicine (Baltimore)2016951:CAS:528:DC%2BC28XktVOiu78%3D2694534910.1097/MD.0000000000002583
– reference: BagAKWingMNSabinNDHwangSNArmstrongGTHanY(11)C-Methionine PET for identification of pediatric high-grade glioma recurrenceJ Nucl Med2022636646711:CAS:528:DC%2BB38XisVyqtr7M344464539051591
– reference: DemetriadesAKAlmeidaACBhangooRSBarringtonSFApplications of positron emission tomography in neuro-oncology: a clinical approachSurgeon2014121481572462984110.1016/j.surge.2013.12.001
– reference: SalberDStoffelsGPauleitDOros-PeusquensAMShahNJKlauthPDifferential uptake of O-(2–18F-fluoroethyl)-L-tyrosine, L-3H-methionine, and 3H-deoxyglucose in brain abscessesJ Nucl Med200748205620621:CAS:528:DC%2BD1cXnvFSmug%3D%3D1800661210.2967/jnumed.107.046615
– reference: HoCLYuSCYeungDW11C-Acetate PET imaging in hepatocellular carcinoma and other liver massesJ Nucl Med20034421322112571212
– reference: ChapmanJDFrankoAJSharplinJA marker for hypoxic cells in tumours with potential clinical applicabilityBr J Cancer1981435465501:CAS:528:DyaL3MXkslKgtLs%3D7236492201062710.1038/bjc.1981.79
– reference: Di ChiroGDeLaPazRLBrooksRASokoloffLKornblithPLSmithBHGlucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomographyNeurology19823213231329698304410.1212/WNL.32.12.1323
– reference: OyamaNAkinoHKanamaruHSuzukiYMuramotoSYonekuraY11C-Acetate PET imaging of prostate cancerJ Nucl Med2002431811861:CAS:528:DC%2BD38XjvFWjtro%3D11850482
– reference: Skoblar Vidmar M, Doma A, Smrdel U, Zevnik K, Studen A. The value of FET PET/CT in recurrent glioma with a different IDH mutation status: the relationship between imaging and molecular biomarkers. Int J Mol Sci. 2022;23:6787.
– reference: KinoshitaMAritaHGotoTOkitaYIsohashiKWatabeTA novel PET index, 18F-FDG-11C-methionine uptake decoupling score, reflects glioma cell infiltrationJ Nucl Med201253170117082300074710.2967/jnumed.112.104992
– reference: HeoJYNamMHYoonHHKimJHwangYJWonWAberrant tonic inhibition of dopaminergic neuronal activity causes motor symptoms in animal models of Parkinson’s diseaseCurr Biol202030276–91
– reference: LiuRSChangCPChuLSChuYKHsiehHJChangCWPET imaging of brain astrocytoma with 1–11C-acetateEur J Nucl Med Mol Imaging2006334204271640459610.1007/s00259-005-0023-0
– reference: VesselleHGriersonJMuziMPugsleyJMSchmidtRARabinowitzPIn vivo validation of 3′deoxy-3′-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumorsClin Cancer Res20028331533231:CAS:528:DC%2BD38XpsVCgtr0%3D12429617
– reference: KimDChoAHwangSHJoKChangJHYunMChoroid plexus as the best reference region for standardized uptake value analysis on C11-acetate PET/CT for grading and predicting prognosis in patients with cerebral gliomasNucl Med Mol Imaging2020542742801:CAS:528:DC%2BB3cXisVOltr7O33281998770482110.1007/s13139-020-00672-5
– reference: JagerPLVaalburgWPruimJde VriesEGLangenKJPiersDARadiolabeled amino acids: basic aspects and clinical applications in oncologyJ Nucl Med2001424324451:CAS:528:DC%2BD3MXmvFOqt7k%3D11337520
– reference: LouisDNPerryAWesselingPBratDJCreeIAFigarella-BrangerDThe 2021 WHO classification of tumors of the central nervous system: a summaryNeuro Oncol202123123112511:CAS:528:DC%2BB3MXisFSht73J34185076832801310.1093/neuonc/noab106
– reference: KimDChunJHYiJHKoHYChungJILeeM11 C-Acetate PET/CT detects reactive astrogliosis helping glioma classificationClin Nucl Med2022478638683586800210.1097/RLU.0000000000004341
– reference: GuedjEVarroneABoellaardRAlbertNLBarthelHvan BerckelBEANM procedure guidelines for brain PET imaging using [(18)F]FDG, version 3Eur J Nucl Med Mol Imaging2022496326513488226110.1007/s00259-021-05603-w
– reference: Reuss AM, Groos D, Buchfelder M, Savaskan N. The acidic brain-glycolytic switch in the microenvironment of malignant glioma. Int J Mol Sci. 2021;22:5518.
– reference: BuschHDavisJRHonigGRAndersonDCNairPVNyhanWLThe uptake of a variety of amino acids into nuclear proteins of tumors and other tissuesCancer Res195919103010391:CAS:528:DyaF3cXhvValug%3D%3D13806375
– reference: JerabekPAPatrickTBKilbournMRDischinoDDWelchMJSynthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissueInt J Rad Appl Instrum A1986375996051:CAS:528:DyaL28Xls1Sntrk%3D302166210.1016/0883-2889(86)90079-1
– reference: EidelbergDTakikawaSDhawanVChalyTRobesonWDahlRStriatal 18F-dopa uptake: absence of an aging effectJ Cereb Blood Flow Metab1993138818881:CAS:528:DyaK2cXhtVSkurs%3D836029410.1038/jcbfm.1993.110
– reference: TakataKKatoHShimosegawaEOkunoTKodaTSugimotoT11C-Acetate PET imaging in patients with multiple sclerosisPLoS ONE2014925369426421972510.1371/journal.pone.0111598
– reference: MasuiKCaveneeWKMischelPSmTORC2 and metabolic reprogramming in GBM: at the interface of genetics and environmentBrain Pathol2015257557591:CAS:528:DC%2BC2MXhvVSlsLbM26526943463601610.1111/bpa.12307
– reference: BrownJMTherapeutic targets in radiotherapyInt J Radiat Oncol Biol Phys2001493193261:STN:280:DC%2BD3M7kvFGlsw%3D%3D1117312410.1016/S0360-3016(00)01482-6
– reference: LawIAlbertNLArbizuJBoellaardRDrzezgaAGalldiksNJoint EANM/EANO/RANO practice guidelines/SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [(18)F]FDG: version 1.0Eur J Nucl Med Mol Imaging.201946540571:CAS:528:DC%2BC1cXisVKrt7bE3051986710.1007/s00259-018-4207-9
– reference: ChungJKKimYKKimSKLeeYJPaekSYeoJSUsefulness of 11C-methionine PET in the evaluation of brain lesions that are hypo- or isometabolic on 18F-FDG PETEur J Nucl Med Mol Imaging2002291761821:CAS:528:DC%2BD38XnvFSmtg%3D%3D1192637910.1007/s00259-001-0690-4
– reference: BarajasRFJrPampaloniMHClarkeJLSeoYSavicDHawkinsRAAssessing biological response to bevacizumab using 18F-fluoromisonidazole PET/MR imaging in a patient with recurrent anaplastic astrocytomaCase Rep Radiol20152015257931364352456
– reference: SinghalTNarayananTKJacobsMPBalCMantilJC11C-Methionine PET for grading and prognostication in gliomas: a comparison study with 18F-FDG PET and contrast enhancement on MRIJ Nucl Med201253170917152305553410.2967/jnumed.111.102533
– reference: CruzNFLasaterAZielkeHRDienelGAActivation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brainJ Neurochem2005929349471:CAS:528:DC%2BD2MXhs1Kqtbs%3D1568649610.1111/j.1471-4159.2004.02935.x
– reference: GlaudemansAWEntingRHHeestersMADierckxRAvan RheenenRWWalenkampAMValue of 11C-methionine PET in imaging brain tumours and metastasesEur J Nucl Med Mol Imaging2013406156351:CAS:528:DC%2BC3sXjslOgsbs%3D2323250510.1007/s00259-012-2295-5
– reference: NamMHKoHYKimDLeeSParkYMHyeonSJVisualizing reactive astrocyte-neuron interaction in Alzheimer’s disease using 11C-acetate and 18F-FDGBrain202314629572974370625411051719510.1093/brain/awad037
– reference: MashimoTPichumaniKVemireddyVHatanpaaKJSinghDKSirasanagandlaSAcetate is a bioenergetic substrate for human glioblastoma and brain metastasesCell2014159160316141:CAS:528:DC%2BC2MXnslKqug%3D%3D25525878437460210.1016/j.cell.2014.11.025
– reference: JohnsonJMChenMMRohrenEMPrabhuSChasenBMawlawiODelayed FDG PET provides superior glioblastoma conspicuity compared to conventional image timingFront Neurol20211234867723863511010.3389/fneur.2021.740280
– reference: WalshJCLebedevAAtenEMadsenKMarcianoLKolbHCThe clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunitiesAntioxid Redox Signal201421151615541:CAS:528:DC%2BC2cXhsFamsrjF24512032415993710.1089/ars.2013.5378
– reference: MiyagawaTOkuTUeharaHDesaiRBeattieBTjuvajevJ“Facilitated” amino acid transport is upregulated in brain tumorsJ Cereb Blood Flow Metab1998185005091:CAS:528:DyaK1cXjsVWitrg%3D959184210.1097/00004647-199805000-00005
– reference: JoSYarishkinOHwangYJChunYEParkMWooDHGABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s diseaseNat Med2014208868961:CAS:528:DC%2BC2cXhtVKlsrfP24973918838545210.1038/nm.3639
– reference: Hirata K, Yamaguchi S, Shiga T, Kuge Y, Tamaki N. The roles of hypoxia imaging using (18)F-fluoromisonidazole positron emission tomography in glioma treatment. J Clin Med. 2019;8:1088.
– reference: LauEWDrummondKJWareREDrummondEHoggARyanGComparative PET study using F-18 FET and F-18 FDG for the evaluation of patients with suspected brain tumourJ Clin Neurosci20101743492000458210.1016/j.jocn.2009.05.009
– reference: YoulandRSKitangeGJPetersonTEPafundiDHRamiscalJAPokornyJLThe role of LAT1 in (18)F-DOPA uptake in malignant gliomasJ Neurooncol201311111181:CAS:528:DC%2BC38XhvFSgtLjP2308643110.1007/s11060-012-0986-1
– reference: MatsubaraKWatabeHKumakuraYHayashiTEndresCJMinatoKSensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism: a simulation study for [(1)(8)F]FDOPA PET by a model with detailed dopamine pathwaySynapse2011657517621:CAS:528:DC%2BC3MXmvFWhtrk%3D2119022010.1002/syn.20899
– reference: ShinomiyaAKawaiNOkadaMMiyakeKNakamuraTKushidaYEvaluation of 3′-deoxy-3′-[18F]-fluorothymidine (18F-FLT) kinetics correlated with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomasEur J Nucl Med Mol Imaging2013401751851:CAS:528:DC%2BC3sXkvVKrtw%3D%3D2322974610.1007/s00259-012-2275-9
– reference: WesterHJHerzMWeberWHeissPSenekowitsch-SchmidtkeRSchwaigerMSynthesis and radiopharmacology of O-(2-[18F]fluoroethyl)-L-tyrosine for tumor imagingJ Nucl Med1999402052121:CAS:528:DyaK1MXos1aitA%3D%3D9935078
– reference: PikeVWEakinsMNAllanRMSelwynAPPreparation of [1-11C]acetate–an agent for the study of myocardial metabolism by positron emission tomographyInt J Appl Radiat Isot1982335055121:CAS:528:DyaL38XltFGgsrs%3D698160610.1016/0020-708X(82)90003-5
– reference: HammondEMAsselinMCForsterDO'ConnorJPSenraJMWilliamsKJThe meaning, measurement and modification of hypoxia in the laboratory and the clinicClin Oncol (R Coll Radiol)2014262772881:STN:280:DC%2BC2crhtlCruw%3D%3D2460256210.1016/j.clon.2014.02.002
– volume: 32
  start-page: 1323
  year: 1982
  ident: 847_CR15
  publication-title: Neurology
  doi: 10.1212/WNL.32.12.1323
– volume: 190
  start-page: W365
  year: 2008
  ident: 847_CR7
  publication-title: AJR Am J Roentgenol
  doi: 10.2214/AJR.07.2660
– volume: 95
  year: 2016
  ident: 847_CR24
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000002583
– volume: 9
  year: 2014
  ident: 847_CR65
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0111598
– volume: 37
  start-page: 599
  year: 1986
  ident: 847_CR94
  publication-title: Int J Rad Appl Instrum A
  doi: 10.1016/0883-2889(86)90079-1
– volume: 35
  start-page: 955
  year: 2015
  ident: 847_CR88
  publication-title: Anticancer Res
– volume: 40
  start-page: 175
  year: 2013
  ident: 847_CR86
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-012-2275-9
– volume: 43
  start-page: 181
  year: 2002
  ident: 847_CR67
  publication-title: J Nucl Med
– volume: 36
  start-page: 422
  year: 2009
  ident: 847_CR68
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-008-0981-0
– ident: 847_CR1
  doi: 10.1093/neuonc/nov189
– volume: 10
  start-page: 281
  year: 2008
  ident: 847_CR73
  publication-title: Mol Imaging Biol
  doi: 10.1007/s11307-008-0152-5
– volume: 21
  start-page: 1516
  year: 2014
  ident: 847_CR89
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5378
– volume: 27
  start-page: 71
  year: 2023
  ident: 847_CR79
  publication-title: Biomater Res
  doi: 10.1186/s40824-023-00408-4
– volume: 65
  start-page: 751
  year: 2011
  ident: 847_CR45
  publication-title: Synapse
  doi: 10.1002/syn.20899
– volume: 49
  start-page: 3852
  year: 2022
  ident: 847_CR13
  publication-title: Eur J Nucl Med Mol Imaging.
  doi: 10.1007/s00259-022-05817-6
– volume: 26
  start-page: 277
  year: 2014
  ident: 847_CR92
  publication-title: Clin Oncol (R Coll Radiol)
  doi: 10.1016/j.clon.2014.02.002
– volume: 43
  start-page: 311
  year: 2018
  ident: 847_CR8
  publication-title: Clin Nucl Med
  doi: 10.1097/RLU.0000000000002006
– volume: 33
  start-page: 932
  year: 2006
  ident: 847_CR42
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-005-0047-5
– volume: 33
  start-page: 505
  year: 1982
  ident: 847_CR52
  publication-title: Int J Appl Radiat Isot
  doi: 10.1016/0020-708X(82)90003-5
– ident: 847_CR97
  doi: 10.3390/ijms22115518
– volume: 104
  start-page: 125
  year: 2002
  ident: 847_CR63
  publication-title: Clin Neurol Neurosurg
  doi: 10.1016/S0303-8467(01)00197-4
– volume: 43
  start-page: 546
  year: 1981
  ident: 847_CR93
  publication-title: Br J Cancer
  doi: 10.1038/bjc.1981.79
– volume: 40
  start-page: 205
  year: 1999
  ident: 847_CR40
  publication-title: J Nucl Med
– volume: 34
  start-page: 878
  year: 2009
  ident: 847_CR85
  publication-title: Clin Nucl Med
  doi: 10.1097/RLU.0b013e3181becfe0
– volume: 49
  start-page: 319
  year: 2001
  ident: 847_CR90
  publication-title: Int J Radiat Oncol Biol Phys
  doi: 10.1016/S0360-3016(00)01482-6
– volume: 146
  start-page: 2957
  year: 2023
  ident: 847_CR64
  publication-title: Brain
  doi: 10.1093/brain/awad037
– volume: 63
  start-page: 664
  year: 2022
  ident: 847_CR37
  publication-title: J Nucl Med
– volume: 48
  start-page: 2056
  year: 2007
  ident: 847_CR41
  publication-title: J Nucl Med
  doi: 10.2967/jnumed.107.046615
– volume: 14
  start-page: 1473
  year: 2012
  ident: 847_CR49
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nos259
– volume: 10
  start-page: 56
  year: 2020
  ident: 847_CR48
  publication-title: EJNMMI Res
  doi: 10.1186/s13550-020-00645-x
– volume: 25
  start-page: 755
  year: 2015
  ident: 847_CR71
  publication-title: Brain Pathol
  doi: 10.1111/bpa.12307
– volume: 42
  start-page: 432
  year: 2001
  ident: 847_CR25
  publication-title: J Nucl Med
– volume: 53
  start-page: 1709
  year: 2012
  ident: 847_CR4
  publication-title: J Nucl Med
  doi: 10.2967/jnumed.111.102533
– volume: 18
  start-page: 426
  year: 2016
  ident: 847_CR43
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/nov148
– volume: 31
  start-page: 1668
  year: 2011
  ident: 847_CR56
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2011.84
– volume: 23
  start-page: 1555
  year: 2020
  ident: 847_CR60
  publication-title: Nat Neurosci
  doi: 10.1038/s41593-020-00735-y
– volume: 47
  start-page: 904
  year: 2006
  ident: 847_CR30
  publication-title: J Nucl Med
– volume: 265
  start-page: 12916
  year: 1990
  ident: 847_CR57
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(19)38247-X
– volume: 33
  start-page: 16
  year: 2014
  ident: 847_CR6
  publication-title: Chin J Cancer
  doi: 10.5732/cjc.013.10217
– volume: 49
  start-page: 632
  year: 2022
  ident: 847_CR14
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-021-05603-w
– volume: 40
  start-page: 1367
  year: 1999
  ident: 847_CR39
  publication-title: J Nucl Med
– ident: 847_CR5
  doi: 10.3413/Nukmed-0662-14-04
– volume: 10
  start-page: 453
  year: 2011
  ident: 847_CR34
  publication-title: Mol Imaging
  doi: 10.2310/7290.2011.00014
– volume: 13
  start-page: 4943
  year: 2023
  ident: 847_CR11
  publication-title: Quant Imaging Med Surg
  doi: 10.21037/qims-22-1340
– volume: 28
  start-page: 1
  year: 2001
  ident: 847_CR16
  publication-title: Nucl Med Biol
  doi: 10.1016/S0969-8051(00)00177-3
– volume: 131
  start-page: 803
  year: 2016
  ident: 847_CR2
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-016-1545-1
– volume: 16
  start-page: 549
  year: 1969
  ident: 847_CR53
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1969.tb06854.x
– volume: 37
  start-page: 429
  year: 2007
  ident: 847_CR81
  publication-title: Semin Nucl Med
  doi: 10.1053/j.semnuclmed.2007.08.001
– volume: 18
  start-page: 500
  year: 1998
  ident: 847_CR28
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1097/00004647-199805000-00005
– volume: 116
  start-page: 597
  year: 2008
  ident: 847_CR23
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-008-0455-2
– ident: 847_CR77
  doi: 10.1093/neuonc/noad243
– volume: 53
  start-page: 1701
  year: 2012
  ident: 847_CR29
  publication-title: J Nucl Med
  doi: 10.2967/jnumed.112.104992
– volume: 45
  start-page: 1012
  year: 2018
  ident: 847_CR75
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-018-3948-9
– volume: 32
  year: 2020
  ident: 847_CR62
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2020.107975
– volume: 9
  year: 2014
  ident: 847_CR87
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0095830
– volume: 12
  year: 2021
  ident: 847_CR20
  publication-title: Front Neurol
  doi: 10.3389/fneur.2021.740280
– volume: 64
  start-page: 2773
  year: 1995
  ident: 847_CR58
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.1995.64062773.x
– volume: 46
  start-page: 1678
  year: 2019
  ident: 847_CR50
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-019-04337-0
– volume: 54
  start-page: 274
  year: 2020
  ident: 847_CR76
  publication-title: Nucl Med Mol Imaging
  doi: 10.1007/s13139-020-00672-5
– volume: 12
  start-page: 148
  year: 2014
  ident: 847_CR18
  publication-title: Surgeon
  doi: 10.1016/j.surge.2013.12.001
– volume: 13
  start-page: 881
  year: 1993
  ident: 847_CR46
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.1993.110
– volume: 7
  start-page: 656
  year: 2020
  ident: 847_CR51
  publication-title: Neurooncol Pract
– volume: 44
  start-page: 213
  year: 2003
  ident: 847_CR69
  publication-title: J Nucl Med
– ident: 847_CR10
  doi: 10.3390/ijms20194669
– volume: 159
  start-page: 1603
  year: 2014
  ident: 847_CR70
  publication-title: Cell
  doi: 10.1016/j.cell.2014.11.025
– ident: 847_CR19
  doi: 10.3390/cancers12071977
– volume: 111
  start-page: 11
  year: 2013
  ident: 847_CR47
  publication-title: J Neurooncol
  doi: 10.1007/s11060-012-0986-1
– volume: 20
  start-page: 886
  year: 2014
  ident: 847_CR59
  publication-title: Nat Med
  doi: 10.1038/nm.3639
– volume: 23
  start-page: 1231
  year: 2021
  ident: 847_CR3
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/noab106
– volume: 47
  start-page: 863
  year: 2022
  ident: 847_CR78
  publication-title: Clin Nucl Med
  doi: 10.1097/RLU.0000000000004341
– ident: 847_CR36
  doi: 10.3390/cancers13194777
– volume: 29
  start-page: 176
  year: 2002
  ident: 847_CR32
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-001-0690-4
– volume: 62
  start-page: 1349
  year: 2021
  ident: 847_CR96
  publication-title: J Nucl Med
  doi: 10.2967/jnumed.120.249524
– volume: 17
  start-page: 43
  year: 2010
  ident: 847_CR31
  publication-title: J Clin Neurosci
  doi: 10.1016/j.jocn.2009.05.009
– volume: 324
  start-page: 192
  year: 2009
  ident: 847_CR22
  publication-title: Science
  doi: 10.1126/science.1173362
– volume: 33
  start-page: 420
  year: 2006
  ident: 847_CR72
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-005-0023-0
– volume: 53
  start-page: 1904
  year: 2012
  ident: 847_CR82
  publication-title: J Nucl Med
  doi: 10.2967/jnumed.112.105544
– volume: 41
  start-page: 369
  year: 2021
  ident: 847_CR66
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1177/0271678X20911469
– volume: 46
  start-page: 540
  year: 2019
  ident: 847_CR12
  publication-title: Eur J Nucl Med Mol Imaging.
  doi: 10.1007/s00259-018-4207-9
– volume: 5
  start-page: 937
  year: 2006
  ident: 847_CR17
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(06)70597-X
– volume: 18
  start-page: 5225
  year: 1998
  ident: 847_CR54
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.18-14-05225.1998
– volume: 63
  start-page: 3791
  year: 2003
  ident: 847_CR80
  publication-title: Cancer Res
– volume: 286
  start-page: 929
  year: 1972
  ident: 847_CR26
  publication-title: N Engl J Med
  doi: 10.1056/NEJM197204272861707
– volume: 8
  start-page: 3315
  year: 2002
  ident: 847_CR84
  publication-title: Clin Cancer Res
– ident: 847_CR91
  doi: 10.3390/jcm8081088
– volume: 91
  start-page: 20170426
  year: 2018
  ident: 847_CR35
  publication-title: Br J Radiol
  doi: 10.1259/bjr.20170426
– volume: 2015
  year: 2015
  ident: 847_CR98
  publication-title: Case Rep Radiol
– volume: 19
  start-page: 1030
  year: 1959
  ident: 847_CR27
  publication-title: Cancer Res
– volume: 92
  start-page: 934
  year: 2005
  ident: 847_CR55
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2004.02935.x
– volume: 12
  year: 2021
  ident: 847_CR9
  publication-title: Front Neurol
  doi: 10.3389/fneur.2021.671867
– volume: 30
  issue: 276–91
  year: 2020
  ident: 847_CR61
  publication-title: Curr Biol
– volume: 54
  start-page: 903
  year: 2013
  ident: 847_CR83
  publication-title: J Nucl Med
  doi: 10.2967/jnumed.112.112201
– volume: 24
  start-page: 1546
  year: 2022
  ident: 847_CR38
  publication-title: Neuro Oncol
  doi: 10.1093/neuonc/noac040
– volume: 35
  start-page: 171
  year: 2008
  ident: 847_CR74
  publication-title: Nucl Med Biol
  doi: 10.1016/j.nucmedbio.2007.11.004
– volume: 32
  start-page: 1185
  year: 2002
  ident: 847_CR21
  publication-title: Free Radic Biol Med
  doi: 10.1016/S0891-5849(02)00815-8
– volume: 40
  start-page: 615
  year: 2013
  ident: 847_CR33
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-012-2295-5
– ident: 847_CR44
  doi: 10.3390/ijms23126787
– volume: 31
  start-page: 513
  year: 2004
  ident: 847_CR95
  publication-title: Eur J Nucl Med Mol Imaging
  doi: 10.1007/s00259-003-1404-x
– reference: 39881977 - Nucl Med Mol Imaging. 2025 Feb;59(1):91. doi: 10.1007/s13139-024-00879-w
SSID ssj0000329037
Score 2.3458104
SecondaryResourceType review_article
Snippet Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive glioma evaluation, offering complementary...
Positron emission tomography/computed tomography (PET/CT) has dramatically altered the landscape of noninvasive gliomaevaluation, offering complementary...
SourceID nrf
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 237
SubjectTerms Amino acids
Cardiology
Computed tomography
Imaging
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Orthopedics
Positron emission
Radioactive tracers
Radiology
Review
방사선과학
Title Recent Update on PET/CT Radiotracers for Imaging Cerebral Glioma
URI https://link.springer.com/article/10.1007/s13139-024-00847-4
https://www.ncbi.nlm.nih.gov/pubmed/38932755
https://www.proquest.com/docview/3071987805
https://www.proquest.com/docview/3072815093
https://pubmed.ncbi.nlm.nih.gov/PMC11196511
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003107671
Volume 58
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Nuclear Medicine and Molecular Imaging , 2024, 58(4), , pp.237-245
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Nb9MwFH-inYS48P0RGJUR3MCjSZzEvtFF6zYQE0KNNE5W_BGo2iVT117463l2k1YdA2mX5OBn69l-z_7Zz_4Z4N2wihJrbUljJjRliIhwHBQVVYlgTAuujPKnLc7Sk4J9Pk_O20thV91p9y4k6Ufq7WW3GNEKxTmFOhL4jLIe7CUhF7wPe6PjH1-2eyvDOBJDT5fpHlxCNTLW3pe5uaCdOalXL6qb4ObfpyavhU79jDR-AEVXl_VBlNnBaqkO9O9rNI-3rexDuN9CVDJa29QjuGPrx3D3axuEfwKfEGqicqS4dLsFpKnJt6PJx3xCvpdm2qDSGiElQTBMTi_8G0gktwsXn56T4_m0uSifQjE-muQntH2IgWp02SVVnFkuNK7O0kxHxoRp5e7HlYjdhKmEQtRXpZkQVghmKwQoYajSlDuiKcszU8bPoF83tX0BxJSJNkalmM-gLZQqs1VWhZozR10Y8gDCriukblnK3WMZc7nlV3ZNI7FppG8ayQJ4v8lzuebo-K_0W-xhOdNT6ai13f9nI2cLiQuIU8yU4AgWxgHsdxYgW6--kjgeuj0aPkwCeLNJRn90QZayts3Ky2C9EYZhEc_XBrNRyoHDKEswN98xpY2AU2g3pZ7-8pzfOCWJFMFxAB86g9nq9e_Kvryd-Cu4F3mbc7tM-9BfLlb2NYKupRqgj40PD88Gra8NoJenOX6LaPQHnpMhKA
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LbxMxEB61qQRcaHkUlhYwghu47MO7a9-oorYJfQihRCona_2CKOlulSYXfj3jzW6ilILU0x7Wtsb2jP15xv4G4EPo4tRaW9CECU0ZIiJcB4WjKhWMacGVUfVti4usN2RfL9PL5lHYTXvbvQ1J1iv16rFbgmiF4p5CPQl8TtkmbDE8g4cd2Do8-XG68q2ESSzCmi7TJ1xCMXLWvJe5u6G1PWmznLq74ObftyZvhU7rHel4G4ZtXxYXUcYH85k60L9v0Tzet7M78LiBqORwoVNPYMOWT-HBeROEfwZfEGqicGR47b0FpCrJt6PB5-6AfC_MqEKhNUJKgmCY9K_qHEika6c-Pj0hJ5NRdVU8h-Hx0aDbo00iBqrRZGdUcWa50Hg6y3IdGxNlzr-PKxC7CeOEQtTnslwIKwSzDgFKFKks455oyvLcFMkudMqqtC-BmCLVxqgM6xnUhULl1uUu0px56sKIBxC1UyF1w1Luk2VM5Ipf2Q-NxKGR9dBIFsDHZZ3rBUfHf0u_xxmWYz2Snlrbf39WcjyVeIDoY6UUV7AoCWC_1QDZWPWNxPXQ-2h4mAbwbvkb7dEHWYrSVvO6DPYbYRg28WKhMEuhPDiM8xRr8zVVWhbwAq3_KUe_as5v3JJEhuA4gE-twqzk-ndnX92v-Ft42Bucn8mz_sXpHjyKa_3zHqd96Mymc_saAdhMvWns7Q-B6SDD
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED-xIU28TIzPwAZG8AZRm8RJ7DemsrLyMU2olfZmxV-sWpdUpfv_uXPTlMJA4ilS7LNs39n-2ef7GeBN36e5c66KMy5NzBER4TwofaxzybmRQlsdblucFacT_ukiv_glij_cdl-7JFcxDcTSVC97c-t7m8C3DJFLjOtLTITwZcx34C6nn2jRk_S4O2XpZ6nsB-JMenoJK1TyNnLm9mK2VqedeuFvA55_3p_8zYka1qbhfdhvQSU7XlnBAdxx9QPY-9q6zR_CewSHWAibzGl_z5qanZ-Me4Mx-1bZaYOFGwSBDOErG12HV4vYwC3IozxjH2fT5rp6BJPhyXhwGrdPJ8QGB9ky1oI7IQ3up4rSpNYmhaeItgrRlrReasRpviildFJy5xFSJIkuCkHUUE6Utsoew27d1O4pMFvlxlpdoJxF7VW6dL70iRGcyAYTEUGy7jJlWl5xet5ipjaMyNTNCrtZhW5WPIK3ncx8xarxz9yvURPqykwVkWHT93ujrhYKIf8IhXKcc5IsgsO1plQ7Dn8onMHoVEX08whedck4gsgtUtWuuQl5sN0InLCIJyvFdpUiOJeWOUqLLZV3GahC2yn19DKwdOMiIguEsxG8W1vHpl5_b-yz_8v-EvbOPwzVl9HZ5-dwLw2mTEdEh7C7XNy4I0RMS_0iDIqfmFYICQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Recent+Update+on+PET%2FCT+Radiotracers+for+Imaging+Cerebral+Glioma&rft.jtitle=Nuclear+medicine+and+molecular+imaging&rft.au=Kim%2C+Dongwoo&rft.au=Lee%2C+Suk-Hyun&rft.au=Hwang%2C+Hee+Sung&rft.au=Kim%2C+Sun+Jung&rft.date=2024-06-01&rft.issn=1869-3474&rft.eissn=1869-3482&rft.volume=58&rft.issue=4&rft.spage=237&rft.epage=245&rft_id=info:doi/10.1007%2Fs13139-024-00847-4&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s13139_024_00847_4
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1869-3474&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1869-3474&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1869-3474&client=summon